Patents by Inventor Nishil Patel

Nishil Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FACTOR IX GENE THERAPY
    Publication number: 20220331409
    Abstract: The invention relates to a new, more potent, coagulation Factor IX (FIX) expression cassette for gene therapy of Haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein, and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.
    Type: Application
    Filed: April 29, 2022
    Publication date: October 20, 2022
    Inventors: Amit NATHWANI, Jenny MCINTOSH, Nishil PATEL
  • Factor IX gene therapy
    Patent number: 11344608
    Abstract: The invention relates to a new, more potent, coagulation Factor IX (FIX) expression cassette for gene therapy of Haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein, and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 31, 2022
    Assignee: UCL BUSINESS LTD
    Inventors: Amit Nathwani, Jenny Mcintosh, Nishil Patel
  • MODIFIED FACTOR IX POLYPEPTIDES
    Publication number: 20210395714
    Abstract: The present invention relates to modified Factor IX polypeptides comprising a mutation at a position corresponding to position 347 of wild type immature (precursor) Factor IX, polynucleotides encoding the polypeptides, and treatments utilising the polypeptides or polynucleotides.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 23, 2021
    Inventors: Amit NATHWANI, Nishil PATEL, Keith GOMEZ
  • FACTOR IX GENE THERAPY
    Publication number: 20190388523
    Abstract: The invention relates to a new, more potent, coagulation Factor IX (FIX) expression cassette for gene therapy of Haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein, and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.
    Type: Application
    Filed: September 6, 2019
    Publication date: December 26, 2019
    Inventors: Amit Nathwani, Jenny Mcintosh, Nishil Patel
  • Factor IX gene therapy
    Patent number: 10413598
    Abstract: The invention relates to a new, more potent, coagulation factor IX (FIX) expression cassette for gene therapy of haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: September 17, 2019
    Assignee: UCL Business PLC
    Inventors: Amit Nathwani, Jenny Mcintosh, Nishil Patel
  • FACTOR IX GENE THERAPY
    Publication number: 20190070271
    Abstract: The invention relates to a new, more potent, coagulation factor IX (FIX) expression cassette for gene therapy of haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 7, 2019
    Inventors: Amit Nathwani, Jenny Mcintosh, Nishil Patel