Patents by Inventor Nitin Puri

Nitin Puri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOSITIONS, METHODS AND KITS FOR URINARY TRACT MICROORGANISM DETECTION
    Publication number: 20250333803
    Abstract: Various methods are disclosed for amplifying nucleic acid sequences in a nucleic acid sample. The methods involve forming at least five amplification reaction mixes each including an aliquot from a sample source that includes nucleic acid sequences, using at least five different assays each including a pair of amplification primers, the assays selected from the group of assays in Table 1 and/or targeting the sequences specified in Table 1.
    Type: Application
    Filed: May 6, 2025
    Publication date: October 30, 2025
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kelly LI, Ioanna PAGANI, Jisheng LI, Sunali PATEL, Kamini VARMA, Jorge FONSECA, Nitin PURI, Evan DIAMOND
  • Compositions, methods and kits for microorganism detection
    Patent number: 12054790
    Abstract: Methods, compositions and kits for detecting microorganisms and/or profiling microbiota such as for example through use of nucleic acid amplification and detection.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 6, 2024
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Ioanna Pagani, Pius Brzoska, Kelly Li, Sunali Patel, Boli Huang, Kamini Varma, Nitin Puri, Evan Diamond
  • siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof
    Patent number: 10900038
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: January 26, 2021
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Maylin Magdaleno, Alexander Vlassov, Christopher Burnett
  • NOVEL COMPOSITIONS, METHODS AND KITS FOR URINARY TRACT MICROORGANISM DETECTION
    Publication number: 20200340041
    Abstract: Various methods are disclosed for amplifying nucleic acid sequences in a nucleic acid sample. The methods involve forming at least five amplification reaction mixes each including an aliquot from a sample source that includes nucleic acid sequences, using at least five different assays each including a pair of amplification primers, the assays selected from the group of assays in Table 1 and/or targeting the sequences specified in Table 1.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 29, 2020
    Inventors: Kelly LI, Ioanna PAGANI, Jisheng LI, Sunali PATEL, Kamini VARMA, Jorge FONSECA, Nitin PURI, Evan DIAMOND
  • NOVEL COMPOSITIONS, METHODS AND KITS FOR MICROORGANISM DETECTION
    Publication number: 20200248239
    Abstract: Methods, compositions and kits for detecting microorganisms and/or profiling microbiota such as for example through use of nucleic acid amplification and detection.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 6, 2020
    Inventors: Ioanna PAGANI, Pius BRZOSKA, Kelly LI, Sunali PATEL, Boli HUANG, Kamini VARMA, Nitin PURI, Evan DIAMOND
  • SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAI, AND STABILIZED FORMS THEREOF
    Publication number: 20190376062
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Application
    Filed: May 10, 2019
    Publication date: December 12, 2019
    Inventors: Nitin Puri, Irudaya Charles, Susan Maylin Magdaleno, Alexander Vlassov, Christopher Burnett
  • siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof
    Patent number: 10329564
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 25, 2019
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Maylin Magdaleno, Alexander Vlassov, Christopher Burnett
  • Compositions and methods for inhibition of nucleic acids function
    Patent number: 10023866
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: July 17, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Christopher Burnett, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAI, AND STABILIZED FORMS THEREOF
    Publication number: 20180057815
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Application
    Filed: September 5, 2017
    Publication date: March 1, 2018
    Inventors: Nitin PURI, Irudaya CHARLES, Susan Maylin MAGDALENO, Alexander VLASSOV, Christopher BURNETT
  • COMPOSITIONS AND METHODS FOR INHIBITION OF NUCLEIC ACIDS FUNCTION
    Publication number: 20180057814
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Application
    Filed: August 30, 2017
    Publication date: March 1, 2018
    Inventors: Christopher BURNETT, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • NOVEL COMPOSITIONS, METHODS AND KITS FOR MICROORGANISM DETECTION
    Publication number: 20170362640
    Abstract: Methods, compositions and kits for detecting microorganisms and/or profiling microbiota such as for example through use of nucleic acid amplification and detection.
    Type: Application
    Filed: June 16, 2017
    Publication date: December 21, 2017
    Inventors: Ioanna PAGANI, Pius BRZOSKA, Kelly LI, Sunali PATEL, Boli HUANG, Kamini VARMA, Nitin PURI, Evan DIAMOND
  • Compositions and methods for inhibition of nucleic acids function
    Patent number: 9783804
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: October 10, 2017
    Assignee: Life Technologies Corporation
    Inventors: Christopher Burnett, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof
    Patent number: 9771583
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: September 26, 2017
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Magdaleno, Alexander Vlassov, Christopher Burnett
  • COMPOSITIONS AND METHODS FOR INHIBITION OF NUCLEIC ACIDS FUNCTION
    Publication number: 20170009232
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 12, 2017
    Inventors: Christopher BURNETT, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAI, AND STABILIZED FORMS THEREOF
    Publication number: 20160230170
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Application
    Filed: February 4, 2016
    Publication date: August 11, 2016
    Inventors: Nitin PURI, Irudaya CHARLES, Susan MAGDALENO, Alexander VLASSOV, Christopher BURNETT
  • Compositions and methods for inhibition of nucleic acids function
    Patent number: 9410153
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: August 9, 2016
    Assignee: Life Technologies Corporation
    Inventors: Christopher Burnett, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • RNAi sequence-independent modification formats, and stabilized forms thereof
    Patent number: 9284551
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 15, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Magdaleno, Alexander Vlassov, Chris Burnett
  • SiRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof
    Patent number: 9273312
    Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: March 1, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Nitin Puri, Irudaya Charles, Susan Magdaleno, Alexander Vlassov, Christopher Burnett
  • Compositions and methods for inhibition of nucleic acids function
    Patent number: 9145556
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: September 29, 2015
    Assignee: Life Technologies Corporation
    Inventors: Christopher Burnett, Nitin Puri, Susan Magdaleno, Alexander Vlassov
  • COMPOSITIONS AND METHODS FOR INHIBITION OF NUCLEIC ACIDS FUNCTION
    Publication number: 20150166992
    Abstract: The invention relates generally to compositions and methods for inhibiting the function of target nucleic acids by sequence specific binding. The compositions and methods can be used for inhibition of micro RNAs and other relatively short non-coding RNAs.
    Type: Application
    Filed: December 9, 2014
    Publication date: June 18, 2015
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: CHRISTOPHER BURNETT, NITIN PURI, SUSAN MAGDALENO, ALEXANDER VLASSOV