Patents by Inventor Nitin U. Jain

Nitin U. Jain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NMR assisted design of high affinity ligands for structurally uncharacterized proteins
    Patent number: 7146277
    Abstract: Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One aspect of the method includes preparing first NMR spectra of a first complex comprising the biological target and a paramagnetically labeled derivative of a first ligand, preparing a second NMR spectra of a second complex comprising the biological target and a second ligand, and analyzing the spectra to determine whether the second ligand binds to the biological target within the paramagnetic zone of the paramagnetically labeled derivative. The first and second steps may be performed simultaneously, consecutively, or in any order.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: December 5, 2006
    Inventors: James H. Prestegard, Nitin U. Jain, Hashim M. Al-Hashimi, Laura C. Morris, Andre P. Venot
  • NMR assisted design of high affinity ligands for structurally uncharacterized proteins
    Publication number: 20020042150
    Abstract: Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and for improving the binding affinity of ligands for biological targets, which in one aspect comprises:
    Type: Application
    Filed: June 13, 2001
    Publication date: April 11, 2002
    Inventors: James H. Prestegard, Nitin U. Jain, Hashim M. Al-Hashimi, Laura C. Morris, Andre P. Venot