Abstract: Liquid drug transfer devices with universal drug vial adapters for use with a drug vial of a small drug vial and a large drug vial. Some universal drug vial adapters employ the same generally opposite upright flex members for clamping a small drug vial and a large drug vial. Other universal drug vial adapters include a set of minor flex members for clamping a small drug vial and a set of major flex members encircling the set of minor flex members for clamping a large drug vial whereupon the large drug vial underlies the set of minor flex members. Liquid drug transfer devices with a universal injection port connector for attachment on an injection port of an infusion bag.

Abstract: Vial assemblages having a vial and a pre-attached fluid transfer device for use with a needleless syringe for enabling flow communication between the syringe and the vial. The fluid transfer device includes an elongated tubular flow member having a connector for sealing flow communication with the needleless syringe and a spike having a spike end for puncturing the vial for enabling flow communication between the needleless syringe and vial interior. The spike end is in intimate sealing contact with the vial's stopper. The fluid transfer device also includes a manually removable closure for initially sealing the connector and, on removal, exposing the connector.

Abstract: Fluid transfer devices for use in manual cartridge filling procedures for filling cartridges with liquid drug dosages from medicament containing vials. The fluid transfer devices include a double ended main body having a longitudinal axis, a vial port for telescopic receiving a drug vial and a cartridge port for slidingly receiving a leading cartridge end. The cartridge port includes a cartridge securing arrangement for releasably securing a leading cartridge end therein and a cartridge ejection arrangement for at least partially ejecting a cartridge therefrom for assisting manual sliding ejection of a filled cartridge. The cartridge port can include either a combined cartridge securing and ejection arrangement or a discrete cartridge securing arrangement and a discrete cartridge ejection arrangement.

Abstract: Valve assemblies for use with a liquid container and a drug vial for enabling an initial transfer of liquid contents from the liquid container to the drug vial for liquid drug formation purposes and subsequent transfer of liquid drug contents from the drug vial to the liquid container for administration purposes. Liquid drug transfer sets can include a valve assembly pre-attached to a liquid container. Alternatively, liquid drug transfer sets can include a valve assembly packaged in sterile blister packaging ready for attachment to a liquid container prior to use.

Abstract: Valve assemblies for use with a liquid container and a drug vial for enabling an initial transfer of liquid contents from the liquid container to the drug vial for liquid drug formation purposes and subsequent transfer of liquid drug contents from the drug vial to the liquid container for administration purposes. Liquid drug transfer sets can include a valve assembly pre-attached to a liquid container. Alternatively, liquid drug transfer sets can include a valve assembly packaged in sterile blister packaging ready for attachment to a liquid container prior to use.

Abstract: Liquid drug transfer devices including a vented vial adapter having a top wall, a downward depending skirt, and a dual lumen puncturing spike. The top wall includes vent apertures in flow communication with an underlying air filter and protective hoods for covering the vent apertures from splashes. The hood-like hoods are preferably quarter sphere shaped with hood apertures facing radial outwards.

Abstract: A fluid transfer assembly including a vented female vial adapter and male vial adapter for use with a pair of vials including a vial with contents under negative pressure for liquid drug reconstitution and administration purposes. The vented female vial adapter includes a venting arrangement and the male vial adapter includes a sealing arrangement for selectively sealing the venting arrangement. The fluid transfer assembly is designed such that only filtered air is drawn into the vial under negative pressure subsequent to reconstitution of liquid drug contents to ensure sterile conditions.

Abstract: The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.

Abstract: Liquid drug transfer devices including a vented vial adapter having a top wall, a downward depending skirt, and a dual lumen puncturing spike. The top wall includes vent apertures in flow communication with an underlying air filter and protective hoods for covering the vent apertures from splashes. The hood-like hoods are preferably quarter sphere shaped with hood apertures facing radial outwards.

Abstract: A fluid transfer assembly including a vented female vial adapter and male vial adapter for use with a pair of vials including a vial with contents under negative pressure for liquid drug reconstitution and administration purposes. The vented female vial adapter includes a venting arrangement and the male vial adapter includes a sealing arrangement for selectively sealing the venting arrangement. The fluid transfer assembly is designed such that only filtered air is drawn into the vial under negative pressure subsequent to reconstitution of liquid drug contents to ensure sterile conditions.

Abstract: The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.

Abstract: Vial assemblages having a vial and a pre-attached fluid transfer device for use with a needleless syringe for enabling flow communication between the syringe and the vial. The fluid transfer device includes an elongated tubular flow member having a connector for sealing flow communication with the needleless syringe and a spike having a spike end for puncturing the vial for enabling flow communication between the needleless syringe and vial interior. The spike end is in intimate sealing contact with the vial's stopper. The fluid transfer device also includes a manually removable closure for initially sealing the connector and, on removal, exposing the connector.

Abstract: Liquid drug delivery device includes a housing with a syringe port for sealingly receiving a syringe having a syringe tip ending at a widened distal tip, a vial adapter port with a vial adapter for snap fit receiving a vial, and a drug administration port for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The syringe port additionally includes a single use locking mechanism for securing the syringe to preclude inadvertent syringe detachment under normal use including agitation for reconstitution purposes. The drug administration port has a distal tip preferably similar to a syringe's widened distal tip for the same purpose of preventing conventional needles with a female Luer connector being slidingly mounted thereon.

Abstract: Liquid drug delivery device includes a housing with a syringe port for sealingly receiving a syringe having a syringe tip ending at a widened distal tip, a vial adapter port with a vial adapter for snap fit receiving a vial, and a drug administration port for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The syringe port additionally includes a single use locking mechanism for securing the syringe to preclude inadvertent syringe detachment under normal use including agitation for reconstitution purposes. The drug administration port has a distal tip preferably similar to a syringe's widened distal tip for the same purpose of preventing conventional needles with a female Luer connector being slidingly mounted thereon.

Abstract: Fluid transfer devices for use with syringes and cartridges having an open ended tube hermetically sealed by a rubber stopper and a slidable seal at opposite leading and trailing ends, respectively. The fluid transfer devices include a syringe port and a cartridge port for correspondingly slidingly receiving a syringe and a cartridge. The cartridge port preferably includes a primary puncturing member and a secondary puncturing member for correspondingly puncturing a cartridge's rubber stopper offset from its center for fluid transfer purposes between a syringe and a cartridge, and venting purposes. The fluid transfer devices are preferably used with stopping devices for preventing ejection of a cartridge's seal during a filling procedure.