Abstract: Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.

Abstract: Systems and methods of self-referenced quantitative phase microscopy (SrQPM). The SrQPM systems and methods provide single-shot, full-field imaging capability for increased imaging speed, and near-common-path geometry for increased phase stability, allowing the study of internal structures of biological cells, live cell dynamics, and the like.

Abstract: Systems and methods of self-referenced quantitative phase microscopy (SrQPM). The SrQPM systems and methods provide single-shot, full-field imaging capability for increased imaging speed, and near-common-path geometry for increased phase stability, allowing the study of internal structures of biological cells, live cell dynamics, and the like.

Abstract: Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.

Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.

Abstract: Epithelial cancer screening can include a staining tissue with a cancer targeting agent, identifying a potentially cancerous lesion using fluorescence imaging, and imaging the potentially cancerous lesion for a cancer diagnosis using optical coherence tomography.

Abstract: Methods and systems for generating near-infrared (NIR) images of biological targets are discussed. In one aspect, one or more radiation sources illuminate a target, with one or more detectors receiving the transmitted radiation. Such equipment can be used to generate a plurality of NIR images of a target. The images can be converted into frequency space, combined using chosen weighting factors, and deconvoluted into the spatial domain to provide a composite image. The composite image can have enhanced quality relative to the individual images, allowing for a richer set of information to be displayed. Other aspects such as scanning, background illumination correction, the use of filters, and additional techniques are also discussed.

Abstract: A system and method for displaying kinematic and kinetic information of a subject is provided. The system includes an image input stage for acquiring image data of the subject, a transformation stage for transforming the image data into three dimensional coordinates corresponding to one or more body segments of the subject, and an output data stage for calculating the kinematic and kinetic information of the subject from the three dimensional coordinates. The system can also include a user interface for displaying the calculated kinematic and kinetic information of the subject.