Patents by Inventor Nnochiri N. Ekwuribe

Nnochiri N. Ekwuribe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
    Publication number: 20030027995
    Abstract: A mixture of conjugates in which each conjugate in the mixture comprises a growth hormone drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed.
    Type: Application
    Filed: June 4, 2001
    Publication date: February 6, 2003
    Inventors: Nnochiri N. Ekwuribe, Christopher H. Price, Aslam M. Ansari, Amy L. Odenbaugh
  • Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
    Publication number: 20030027748
    Abstract: A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.
    Type: Application
    Filed: June 4, 2001
    Publication date: February 6, 2003
    Inventors: Nnochiri N. Ekwuribe, Chirstopher H. Price, Aslam M. Ansari, Balasingam Radhakrishnan, Amy L. Odenbaugh
  • Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
    Publication number: 20030004304
    Abstract: Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include:
    Type: Application
    Filed: June 4, 2001
    Publication date: January 2, 2003
    Inventors: Nnochiri N. Ekwuribe, Christopher H. Price, Aslam M. Ansari, Amy L. Odenbaugh
  • Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
    Patent number: 6479692
    Abstract: Methods of synthesizing an acylanilide
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: November 12, 2002
    Assignee: Nobex Corporation
    Inventors: Nnochiri N. Ekwuribe, Kenneth D. James, Jr.
  • METHODS OF SYNTHESIZING ACYLANILIDES INCLUDING BICALUTAMIDE AND DERIVATIVES THEREOF
    Publication number: 20020165406
    Abstract: Methods of synthesizing an acylanilide include contacting a compound having the structure of Formula I: 1
    Type: Application
    Filed: May 2, 2001
    Publication date: November 7, 2002
    Inventors: Nnochiri N. Ekwuribe, Kenneth D. James
  • Taxane prodrugs
    Publication number: 20020013484
    Abstract: Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.
    Type: Application
    Filed: March 9, 2001
    Publication date: January 31, 2002
    Inventors: Nnochiri N. Ekwuribe, Christopher H. Price, Gary S. Bartley
  • Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
    Patent number: 5438040
    Abstract: A stabilized conjugated peptide complex comprising a peptide conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the peptide may, for example, be selected from the group consisting of insulin, calcitonin, ACTH, glucagon, somatostatin, somatotropin, somatomedin, parathyroid hormone, erythropoietin, hypothalamic releasing factors, prolactin, thyroid stimulating hormones, endorphins, enkephalins, vasopressin, non-naturally occurring opioids, superoxide dismutase, interferon, asparaginase, arginase, arginine deaminease, adenosine deaminase, ribonuclease, trypsin, chymotrypsin, and papain.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: August 1, 1995
    Assignee: Protein Delivery, Inc.
    Inventor: Nnochiri N. Ekwuribe
  • Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
    Patent number: 5359030
    Abstract: A stabilized conjugated peptide complex comprising a peptide conjugatively coupled to a polymer including lipophilic and hydrophilic moieties, wherein the peptide may for example be selected from the group consisting of insulin, calcitonin, ACTH, glucagon, somatostatin, somatotropin, somatomedin, parathyroid hormone, erythropoietin, hypothalamic releasing factors, prolactin, thyroid stimulating hormones, endorphins, enkephalins, vasopressin, non-naturally occurring opioids, superoxide dismutase, interferon, asparaginase, arginase, arginine deaminease, adenosine deaminase, ribonuclease, trypsin, chymotrypsin, and papain.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: October 25, 1994
    Assignee: Protein Delivery, Inc.
    Inventor: Nnochiri N. Ekwuribe