Abstract: Synthetic RNA molecules comprising at least two first RNA-binding protein (RBP)-binding motifs, at least two second RBP-binding motifs and at least two third RBP-binding motifs, wherein the at least two first RBP-binding motifs bind the same first RBP and comprise non-identical sequences are provided. Synthetic RNA molecules comprising at least two RBP-binding motifs, a regulatory element and an open reading frame wherein the RBP-binding motifs individually repress translation and cooperatively enhance translation of the open reading frame are also provided. Methods employing machine learning models to determine variant sequence binding to RBPs are also provided.

Abstract: A method of producing freeform lenses for a PSP laser line system having a laser line diode and a set of three freeform lenses aligned along an optical alignment axis, the set of freeform lenses configured to yield a resultant laser line, the method including: (a) calculating lens surfaces for a lens form to fabricate a lens of the lens set therefrom; (b) fabricating a plurality of slices of the lens form, the plurality of slices distributed over a width “SW” of the lens, wherein each the slices has a width dimension “SL”; (c) aligning and constraining together the plurality of slices to fabricate the lens form, and molding a lens using the fabricated lens form; (d) repeating steps (a) to (c) to produce all three lenses of the set of lenses; and (e) integrating the produced lens set into the laser line system; the resultant laser line having a length “L” and a width “W” and a power uniformity evaluated along L.

Abstract: Synthetic RNA molecules comprising at least two RNA-binding protein (RBP)-binding motifs, wherein the at least two RBP-binding motifs bind the same first RBP and comprise non-identical sequences are provided. Synthetic RNA molecules comprising an RBP-binding motif that binds two orthogonal RBPs, comprising at least three RBP-binding motifs for three orthogonal RBPs or comprising a first RBP-binding motif, a second RBP-binding motif, a regulatory element and an open reading frame wherein the first and second RBP-binding motifs cooperatively enhance translation of the open reading frame are also provided. Compositions, cells and methods of use or generating the synthetic RNA molecules are also provided.

Abstract: Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3?-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.

Abstract: Chimeric polypeptides comprising a dihydrotestosterone (DHT) reductase moiety, such as 3 alpha-hydroxysteroid dehydrogenase (3?-HSD), fused to a signal peptide moiety, polynucleotides encoding same, and compositions comprising at least one microorganism cell capable of secreting the chimeric polypeptide, are provided. Further provided are methods and kits for treating, preventing or ameliorating androgen-dependent disorders, including but not limited to androgenic alopecia.

Abstract: Apparatus and method for supporting and shaping a photo-stimulable phosphor plate (PSP) during scanning in a CR reader, the apparatus including elements for shaping at least part of a PSP to an arc which is a part cylinder, and which provides a substantially unitary radial distance from a beam deflecting device to a target point of scanning.

Abstract: Apparatus and method for supporting and shaping a photo-stimulable phosphor plate (PSP) during scanning in a CR reader, the apparatus including elements for shaping at least part of a PSP to an arc which is a part cylinder, and which provides a substantially unitary radial distance from a beam deflecting device to a target point of scanning.