Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A tool includes a first output from a gear system, the first output along a first axis and a second output from the gear system, the second output along a second axis. A first torque limiter is attached to the first output along the first axis and a second torque limiter is attached to the second output along the second axis. A first tool bit is attached to the first torque limiter along the first axis and a second tool bit attached to the second torque limiter along the second axis.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Disclosed are cylindrical-coordinate 3D printers and methods of 3D printing. In one embodiment, the cylindrical-coordinate 3D printer can comprise a printbed, a rotatable printbed support assembly, a vertically translatable base plate supporting the printbed support assembly, four rail segments aligned radially with the printbed support assembly, and four gantry carriers configured to carry or support four printheads. The gantry carriers can be moveable along the rail segments. The four gantry carriers can be moved simultaneously.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The generation of an online reputation report for an individual is disclosed. First, an online reputation assessment is performed for an individual. Then, a report is generated. The report includes an individualized recommendation based on the online reputation assessment. The recommendation can be directed to the individual and can also be directed to an entity other than the individual.

Abstract: An online reputation assessment of an individual is performed. A reputation score is determined based on the performed online reputation assessment. The reputation score is provided as output. In some cases, the reputation score is provided to an entity that is not the individual, for example, based on the receipt of an authorization from the individual to disclose the score to the entity.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides a compound of formula 1 or a pharmaceutically-acceptable salt thereof, that is useful as a JAK inhibitor. The invention also provides crystalline forms of the compound, pharmaceutical compositions comprising the compound, methods of using the compound to treat diseases amenable to a JAK inhibitor, and processes and intermediates useful for preparing the compound.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Enabling a user interface (UI) for management of a host device from a client device. A connection is established between the host device and the client device via a web portal. The host device and the client device are without a host management software installed thereon. A content window is displayed on the client device in response to the established connection with the host device. A client status display area is displayed on the client device indicating at least a connection status with the host device. A corresponding host status display area is displayed on the host device indicating a connection status with the client device. The displayed client status display area specifically identifies the client device and defines client parameters for receiving messages during management of the host device. The displayed host status display area specifically identifies the host device and defines host parameters for receiving messages during interaction with the client device.

Abstract: An online reputation assessment of an individual is performed. A reputation score is determined based on the performed online reputation assessment. The reputation score is provided as output. In some cases, the reputation score is provided to an entity that is not the individual, for example, based on the receipt of an authorization from the individual to disclose the score to the entity.

Abstract: The generation of an online reputation report for an individual is disclosed. First, an online reputation assessment is performed for an individual. Then, a report is generated. The report includes an individualized recommendation based on the online reputation assessment. The recommendation can be directed to the individual and can also be directed to an entity other than the individual.

Abstract: A method is provided for detecting friend or potential friend candidates as being suspicious in an OSN. A processor is used to obtain at least one candidate as being a suspicious friend in the OSN. One or more risk factors are used in the analysis. Heuristics are applied to the risk factors with the processor. In response, a determination is made as to whether the candidate is a suspicious individual. The processor can be software, hardware, or one or more individuals can use manual methods, to do the analysis and make the determination.

Abstract: A method is provided of monitoring activity relative to a user's account of an on-line social network website (OSN). At least one activity of the user's account on an OSN is monitored, resulting in user's account activity data. Analysis of the user's account activity data is performed. Information is reported that is indicative of the processed user's account activity based on a selected criteria. A system is provided for authenticating a parent or legal guardian of a child on a social network.

Abstract: A method is provided for detecting friend or potential friend candidates as being suspicious in an OSN. A processor is used to obtain at least one candidate as being a suspicious friend in the OSN. One or more risk factors are used in the analysis. Heuristics are applied to the risk factors with the processor. In response, a determination is made as to whether the candidate is a suspicious individual. The processor can be software, hardware, or one or more individuals can use manual methods, to do the analysis and make the determination.

Abstract: Enabling a user interface (UI) for management of a host device from a client device. A connection is established between the host device and the client device via a web portal. The host device and the client device are without a host management software installed thereon. A content window is displayed on the client device in response to the established connection with the host device. A client status display area is displayed on the client device indicating at least a connection status with the host device. A corresponding host status display area is displayed on the host device indicating a connection status with the client device. The displayed client status display area specifically identifies the client device and defines client parameters for receiving messages during management of the host device. The displayed host status display area specifically identifies the host device and defines host parameters for receiving messages during interaction with the client device.