Patents by Inventor Noah Davidsohn

Noah Davidsohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systemic Delivery of Polypeptides
    Publication number: 20240091384
    Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
    Type: Application
    Filed: May 30, 2023
    Publication date: March 21, 2024
    Inventors: Denitsa M. Milanova, George M. Church, Noah Davidsohn, Carl Schoellhammer, Robert S. Langer, Anna I. Mandinova, Carlo Giovanni Traverso
  • Systemic delivery of polypeptides
    Patent number: 11701437
    Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: July 18, 2023
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital Corporation
    Inventors: Denitsa M. Milanova, George M. Church, Noah Davidsohn, Carl Schoellhammer, Robert S. Langer, Anna I. Mandinova, Carlo Giovanni Traverso
  • Methods for Treating Osteoarthritis
    Publication number: 20230024183
    Abstract: Methods are provided for treating osteoarthritis by administering ?Klotho protein and sTGF?-R2 protein to a site within a mammal exhibiting symptoms of osteoarthritis, such as a knee joint. The ?Klotho protein and the sTGF?-R2 protein are both present at the osteoarthritic site.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 26, 2023
    Inventors: Paloma Martinez Redondo, Isabel Guillen-Guillen, Juan Carlos Izpisua Belmonte, Noah Davidsohn, George M. Church, Pedro Guillen Garcia
  • Systemic Delivery of Polypeptides
    Publication number: 20200375868
    Abstract: A method of delivering a recombinant virus to a skin tissue is provided. The method includes applying ultrasound to the skin tissue, and administering the recombinant virus to the skin tissue.
    Type: Application
    Filed: May 14, 2018
    Publication date: December 3, 2020
    Inventors: Denitsa M. Milanova, George M. Church, Noah Davidsohn, Carl Schoellhammer, Robert S. Langer, Anna I. Mandinova, Carlo Giovanni Traverso, Li Li
  • Systemic Delivery of Polypeptides
    Publication number: 20200197538
    Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
    Type: Application
    Filed: May 14, 2018
    Publication date: June 25, 2020
    Inventors: Denitsa M. Milanova, George M. Church, Noah Davidsohn, Carl Schoellhammer, Robert S. Langer, Anna I. Mandinova, Carlo Giovanni Traverso
  • Gene Therapy Methods for Age-Related Diseases and Conditions
    Publication number: 20190345224
    Abstract: Methods of gene therapy are provided for treating or preventing age-related diseases or conditions by regulating one or more functional proteins associated with age-related diseases or conditions.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 14, 2019
    Inventors: Noah Davidsohn, George M. Church