Patents by Inventor Noah WELKER
Noah WELKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150846Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.Type: ApplicationFiled: January 11, 2024Publication date: May 9, 2024Applicant: MYRIAD WOMEN'S HEALTH, INC.Inventors: Jared Robert Maguire, Clement S. Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Patent number: 11932910Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: GrantFiled: July 22, 2021Date of Patent: March 19, 2024Assignee: Myriad Women's Health, Inc.Inventors: Jared Robert Maguire, Clement S. Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Publication number: 20240076750Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.Type: ApplicationFiled: November 8, 2023Publication date: March 7, 2024Applicant: Myriad Women's Health, Inc.Inventors: Jared Robert Maguire, Clement S. Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Publication number: 20230416729Abstract: High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health risks. However, previous methods of nucleic acid sequencing often introduces sequencing errors (for example, mutations that arise during the preparation of a nucleic acid library, during amplification, or sequencing). Provided herein are sequencing adapters comprising a nondegenerate or variable length molecular barcode and compositions comprising a plurality of sequencing adapters, which can be useful for sequencing nucleic acids. Further provided are methods of using the sequencing adapters, including methods of sequencing nucleic acids, methods of identifying an error in a nucleic acid sequence, and methods of determining the number of nucleic acid molecules in a library.Type: ApplicationFiled: June 12, 2023Publication date: December 28, 2023Applicant: MYRIAD WOMEN'S HEALTH, INC.Inventors: Eric Andrew Evans, Imran Saeedul Haque, Kyle Beauchamp, Clement Chu, Carlo G. Artieri, Noah Welker
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Publication number: 20230295716Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.Type: ApplicationFiled: August 8, 2022Publication date: September 21, 2023Applicant: MYRIAD WOMEN'S HEALTH, INC.Inventors: Jared Robert Maguire, Clement S. Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Patent number: 11708574Abstract: High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health risks. However, previous methods of nucleic acid sequencing often introduces sequencing errors (for example, mutations that arise during the preparation of a nucleic acid library, during amplification, or sequencing). Provided herein are sequencing adapters comprising a nondegenerate or variable length molecular barcode and compositions comprising a plurality of sequencing adapters, which can be useful for sequencing nucleic acids. Further provided are methods of using the sequencing adapters, including methods of sequencing nucleic acids, methods of identifying an error in a nucleic acid sequence, and methods of determining the number of nucleic acid molecules in a library.Type: GrantFiled: June 9, 2017Date of Patent: July 25, 2023Assignee: Myriad Women's Health, Inc.Inventors: Eric Andrew Evans, Imran Saeedul Haque, Kyle Beauchamp, Clement Chu, Carlo G. Artieri, Noah Welker
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Publication number: 20230193247Abstract: Described herein are methods for enriching test samples for target nucleic acid molecules for further genetic screening. Methods may comprise isolating nucleic acid from test subjects, preparing nucleic acid libraries wherein the nucleic acid molecules are tagged or barcoded to identify sample of origin, determining fragment size distribution, determining abundance of a target nucleic acid population, calculating numerical offset values to determine amount of libraries to add for fragment size selection, performing fragment size selection, and performing a diagnostic assay on a sample enriched for a target nucleic acid.Type: ApplicationFiled: May 18, 2021Publication date: June 22, 2023Applicant: Myriad Women's Health, Inc.Inventors: Clement Chu, Mark Theilmann, Noah Welker, Peter Grauman
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Publication number: 20220290229Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: ApplicationFiled: February 23, 2022Publication date: September 15, 2022Applicant: MYRIAD WOMEN'S HEALTH, INC.Inventors: Jared Robert Maguire, Clement S. Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Publication number: 20210348229Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: ApplicationFiled: July 22, 2021Publication date: November 11, 2021Applicant: Myriad Women's Health, Inc.Inventors: Jared Robert MAGUIRE, Clement CHU, Imran Saeedul HAQUE, Eric Andrew EVANS, Noah WELKER
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Publication number: 20200157622Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: ApplicationFiled: February 7, 2020Publication date: May 21, 2020Applicant: MYRIAD WOMEN'S HEALTH, INC.Inventors: Jared Robert MAGUIRE, Clement CHU, Imran Saeedul HAQUE, Eric Andrew EVANS, Noah WELKER
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Patent number: 10597717Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: GrantFiled: March 21, 2017Date of Patent: March 24, 2020Assignee: MYRIAD WOMEN'S HEALTH, INC.Inventors: Jared Robert Maguire, Clement Chu, Imran Saeedul Haque, Eric Andrew Evans, Noah Welker
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Publication number: 20180201994Abstract: Capture probe libraries can be used to enrich a region of interest in a sequencing library for high-depth sequencing. The capture probes within the capture probe libraries often do not function in a predictable or uniform manner. Described herein are balanced capture probe libraries and methods of balancing capture probe libraries. A sequencing library can be enriched using balanced capture probe libraries, and the enriched sequencing library can be sequenced to obtain a sequencing depth closer to a desired sequencing depth.Type: ApplicationFiled: January 17, 2018Publication date: July 19, 2018Inventors: Kyle BEAUCHAMP, Dale MUZZEY, Noah WELKER, Jared Robert MAGUIRE
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Publication number: 20170355984Abstract: High-fidelity, high-throughput nucleic acid sequencing enables healthcare practitioners and patients to gain insight into genetic variants and potential health risks. However, previous methods of nucleic acid sequencing often introduces sequencing errors (for example, mutations that arise during the preparation of a nucleic acid library, during amplification, or sequencing). Provided herein are sequencing adapters comprising a nondegenerate or variable length molecular barcode and compositions comprising a plurality of sequencing adapters, which can be useful for sequencing nucleic acids. Further provided are methods of using the sequencing adapters, including methods of sequencing nucleic acids, methods of identifying an error in a nucleic acid sequence, and methods of determining the number of nucleic acid molecules in a library.Type: ApplicationFiled: June 9, 2017Publication date: December 14, 2017Inventors: Eric Andrew EVANS, Imran Saeedul HAQUE, Kyle BEAUCHAMP, Clement CHU, Carlo G. ARTIERI, Noah WELKER
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Publication number: 20170275689Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.Type: ApplicationFiled: March 21, 2017Publication date: September 28, 2017Inventors: Jared Robert MAGUIRE, Clement CHU, Imran Saeedul HAQUE, Eric Andrew EVANS, Noah WELKER