Patents by Inventor Noal Cohen

Noal Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mixtures of 3-pentenenitriles and 3-methylene-pentanenitriles
    Patent number: 4192816
    Abstract: Preparation of chroman-2-acetic acid from 2-hydroxy-chromanes or derivatives thereof and intermediates in this synthesis.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: March 11, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Noal Cohen
  • Protected alcohols
    Patent number: 4191842
    Abstract: A synthesis of vitamin E in racemic or optically active forms from methacryolein or beta-hydroxyisobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: January 17, 1979
    Date of Patent: March 4, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • S-(+) 2,3,6-trimethyl-5-(2,2,4-trimethyl-1,3-dioxolane-4-ethyl)phenol
    Patent number: 4189612
    Abstract: Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: February 19, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Preparation of chroman-2-acetic acids
    Patent number: 4186138
    Abstract: Preparation of chroman-2-acetic acid from 2-hydroxy-chromanes or derivatives thereof and intermediates in this synthesis.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: January 29, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Noal Cohen
  • Synthesis of optically active vitamin E
    Patent number: 4182719
    Abstract: Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: January 8, 1980
    Assignee: Hoffman-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Unsaturated alcohols having an ether protected group
    Patent number: 4180682
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: December 25, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Ethers of 2,6,10-trimethyl-undecan-1-ols
    Patent number: 4172958
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: October 30, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Ethers of 2,6-dimethyl-octane-1,8-diols
    Patent number: 4169209
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: September 25, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Synthesis of 2,6,10-trimethyl-undecan-1-ol
    Patent number: 4163021
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: July 31, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Synthesis of vitamin E
    Patent number: 4151205
    Abstract: A synthesis of vitamin E in racemic or optically active forms from methacryolein or beta-hydroxyisobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: April 24, 1979
    Assignee: Hoffman-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Synthesis of optically active vitamin E
    Patent number: 4151177
    Abstract: Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: April 24, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • 3,6-Dioxo-1,4-cyclohexadien-1-yl-butandate esters
    Patent number: 4150050
    Abstract: A process for inversion of the stereo configuration of (R)-(+)-3,4-dihydro-6-hydroxy-2,5,7,8-tetraalkyl-2H-1-benzopyran-2-carboxy lic acid and derivatives thereof to form the corresponding S-(-) acid and intermediates in this process.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: April 17, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Noal Cohen
  • Process for producing vitamin E intermediate compounds
    Patent number: 4140702
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta. -hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: February 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Intermediate compounds for producing vitamin E
    Patent number: 4140723
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: February 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Synthesis of optically active vitamin E
    Patent number: 4113740
    Abstract: Synthesis of optically active vitamin E from 2-methyl-5-oxotetrahydro-2-furoic acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 17, 1977
    Date of Patent: September 12, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Silicon ester of carboxylic acid
    Patent number: 4111961
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 16, 1977
    Date of Patent: September 5, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Synthesis of optically active carboxylic acid esters
    Patent number: 4107183
    Abstract: A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.
    Type: Grant
    Filed: May 16, 1977
    Date of Patent: August 15, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Steroid total synthesis process utilizing a cyanoalkyl A-ring precursor
    Patent number: 4105676
    Abstract: A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents .gamma.-butyrolactone and sodium cyanide. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly 19-norsteroids. It is a feature of this process that conditions employed during the multiple step synthesis are selected so as to retain the normally labile nitrile group even during hydrogenation and hydrolysis steps. In this manner, it is possible to employ the nitrile group as an A-ring precursor without resorting to protective groups as was heretofore found necessary in previous steroid total synthesis processes.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: August 8, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Michael Rosenberger, Gabriel Saucy
  • Steroid total synthesis process utilizing asymmetric induction
    Patent number: 4102925
    Abstract: A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.
    Type: Grant
    Filed: December 22, 1976
    Date of Patent: July 25, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy
  • Intermediates for steroid total synthesis process utilizing asymmetric induction
    Patent number: 4092483
    Abstract: A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.
    Type: Grant
    Filed: September 24, 1975
    Date of Patent: May 30, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy