Patents by Inventor Noboru Konishi
Noboru Konishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9857375Abstract: The present invention provides a novel cancer marker that is useful in the diagnosis of urothelial cancer. The present invention uses ubiquilin 2 as a cancer marker for urothelial cancer (renal pelvis cancer, ureteral cancer, and bladder cancer). Detection of ubiquilin 2 in a urine sample allows easy and accurate diagnosis of a possibility of urothelial cancer. The present invention is also applicable to the diagnosis of squamous cancer (esophageal cancer, cervical cancer, etc.).Type: GrantFiled: September 26, 2013Date of Patent: January 2, 2018Assignee: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITYInventors: Noboru Konishi, Keiji Shimada
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Publication number: 20150260722Abstract: The present invention provides a novel cancer marker that is useful in the diagnosis of urothelial cancer. The present invention uses ubiquilin 2 as a cancer marker for urothelial cancer (renal pelvis cancer, ureteral cancer, and bladder cancer). Detection of ubiquilin 2 in a urine sample allows easy and accurate diagnosis of a possibility of urothelial cancer. The present invention is also applicable to the diagnosis of squamous cancer (esophageal cancer, cervical cancer, etc.).Type: ApplicationFiled: September 26, 2013Publication date: September 17, 2015Inventors: Noboru Konishi, Keiji Shimada
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Publication number: 20140068854Abstract: The nursing care support device according to the present invention can help to lift and transfer a person who requires nursing care and cannot rise up and walk on their own. The nursing care support device of the present invention can ease the burden of a caregiver and a person who requires nursing care at the time of the use. The nursing care support device of the present invention can also be used as a walking auxiliary device such as a walker for a person who recovers enough to walk using a walk assistance device.Type: ApplicationFiled: September 7, 2012Publication date: March 13, 2014Inventor: Noboru Konishi
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Publication number: 20100297145Abstract: Disclosed is an apoptosis promoter, cell proliferation inhibitor, prophylactic/therapeutic agent for cancer or the like which comprises a compound capable of inhibit the expression or function of PCA-1 as an active ingredient. Also disclosed is a method for screening of a compound for use in the promotion of apoptosis, the inhibition of cell proliferation or the prevention/treatment of cancer, which comprises selecting a compound capable of inhibit the expression or function of PCA-1, or the like.Type: ApplicationFiled: August 4, 2006Publication date: November 25, 2010Inventors: Kazutake Tsujikawa, Hiroshi Yamamoto, Noboru Konishi
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Patent number: 7547675Abstract: The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.Type: GrantFiled: February 13, 2003Date of Patent: June 16, 2009Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Ken Kobayashi, Noboru Konishi, Shiro Akinaga, Kumiko Maruyama
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Publication number: 20090130662Abstract: The present invention provides a method for detecting and/or quantifying PCA-1 in a body fluid sample from a subject as a prostate cancer marker. The present invention also provides a method for detecting and/or quantifying an anti-PCA-1 autoantibody in a body fluid sample from a subject as a prostate cancer marker. The present invention allows diagnosis of prostate cancer to be performed more simply, more rapidly and at lower cost.Type: ApplicationFiled: March 14, 2006Publication date: May 21, 2009Inventors: Kazutake Tsujikawa, Hiroshi Yamamoto, Noboru Konishi
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Patent number: 7358061Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.Type: GrantFiled: September 21, 2004Date of Patent: April 15, 2008Assignee: Fuso PHarmaceutical Industries, Ltd.Inventors: Hiroshi Yamamoto, Kazutake Tsujikawa, Yukiko Uchino, Noboru Konishi
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Publication number: 20080020375Abstract: The present invention relates to a method for determining a subject having a risk of having developed or developing prostate cancer, which comprises the following steps: a) a step of analyzing the presence/absence or level of mutation in the PCA-1 gene derived from the subject; and b) a step of evaluating the presence/absence or level of the subject's risk of having developed or developing prostate cancer, based on the presence/absence or level of mutation in the PCA-1 gene. According to the determination method of prostate cancer of the present invention, a subject having a risk of having developed or developing prostate cancer can be determined conveniently and highly sensitively. Therefore, the method is effective for the diagnosis of prostate cancer, progress monitoring, prognostic prediction, diagnosis before the onset, carrier diagnosis and the like.Type: ApplicationFiled: August 24, 2004Publication date: January 24, 2008Inventors: Hiroshi Yamamoto, Noboru Konishi, Kazutake Tsujikawa
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Patent number: 6884419Abstract: The present invention relates to a fusion polypeptide which comprises a polypeptide having G-CSF activity and a polypeptide having TPO activity and DNA which codes for the fusion polypeptide, to a fusion polypeptide in which a polypeptide having G-CSF activity and a polypeptide having TPO activity are fused via a spacer peptide and DNA which codes for the fusion polypeptide and to a polypeptide in which the fusion polypeptide comprising a polypeptide having G-CSF activity and a polypeptide having TPO activity is chemically modified with a polyalkylene glycol derivative. It also relates to an anemia-treating composition containing the fusion polypeptide as an active ingredient.Type: GrantFiled: October 6, 2000Date of Patent: April 26, 2005Assignee: Kyowa Hakko Kogyo, Co., Ltd.Inventors: Haruhiko Yokoi, Yukimasa Shiotsu, Noboru Konishi, Hideharu Anazawa, Tatsuya Tamaoki, Motoo Yamasaki, Yoko Kato, Kazuhisa Uchida, Kinya Yamashita
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Publication number: 20050042222Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.Type: ApplicationFiled: September 21, 2004Publication date: February 24, 2005Applicant: FUSO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Hiroshi Yamamoto, Kazutake Tsujikawa, Yukiko Uchino, Noboru Konishi
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Publication number: 20050026232Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.Type: ApplicationFiled: September 21, 2004Publication date: February 3, 2005Applicant: FUSO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Hiroshi Yamamoto, Kazutake Tsujikawa, Yukiko Uchino, Noboru Konishi
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Patent number: 6846912Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.Type: GrantFiled: June 7, 1999Date of Patent: January 25, 2005Assignee: Fuso Pharmaceutical Industries, Ltd.Inventors: Hiroshi Yamamoto, Kazutake Tsujikawa, Yukiko Uchino, Noboru Konishi
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Publication number: 20050008645Abstract: Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed.Type: ApplicationFiled: June 7, 1999Publication date: January 13, 2005Inventors: Hiroshi Yamamoto, Kazutake Tsujikawa, Yukiko Uchino, Noboru Konishi
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Publication number: 20030195339Abstract: The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.Type: ApplicationFiled: February 13, 2003Publication date: October 16, 2003Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Ken Kobayashi, Noboru Konishi, Shiro Akinaga, Kumiko Maruyama
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Patent number: 6583267Abstract: The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.Type: GrantFiled: February 3, 1999Date of Patent: June 24, 2003Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Ken Kobayashi, Noboru Konishi, Shiro Akinaga, Kumiko Maruyama
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Publication number: 20020028912Abstract: The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.Type: ApplicationFiled: February 3, 1999Publication date: March 7, 2002Inventors: MOTOO YAMASAKI, TOSHIYUKI SUZAWA, KEN KOBAYASHI, NOBORU KONISHI, SHIRO AKINAGA, KUMIKO MARUYAMA