Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.

Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.

Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.

Abstract: An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.

Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.

Abstract: The present invention provides a method of obtaining information for the diagnosis or treatment, mainly of cancer or an immune system-related disease, the method including the step of quantifying the expression level of a cancer-associated protein or a nucleic acid in a tumor cell; and/or the step of quantifying the expression level of a protein or a nucleic acid in an immune cell, using a specimen derived from tumor tissue of a human or a non-human.

Abstract: Disclosed herein is a method including: acquiring one or more pieces of information including information about expression status of a specific biomarker in a lesion collected from a human by using a laboratory animal transplanted with the lesion; and using the information to estimate therapeutic efficacy through analysis

Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.

Abstract: A substrate for an electro-optical device includes, on a base material, a third interlayer insulation layer, a plurality of first wirings with a light shielding property which are provided on the third interlayer insulation layer, a concave portion provided in the third interlayer insulation layer (second interlayer insulation layer) of a region interposed by adjacent first wirings of the plurality of first wirings in a plan view, a protective film provided so as to cover at least the plurality of first wirings, a color filter provided in the concave portion, a second oxide film provided on the color filters and the plurality of first wirings, and a pixel electrode provided on the second oxide film.

Abstract: An ink ribbon cartridge includes: a supply spool which has at one end portion a driving hole, with which a driving shaft of a printer apparatus is engaged; a winding spool which has at one end portion a driving hole, with which the driving shaft of the printer apparatus is engaged; and a cartridge main body which has a supply-side ribbon housing section, a winding-side ribbon housing section, and a thermal head entry opening portion formed between the supply-side and winding-side ribbon housing sections, and in which opening portions for the ribbon are formed on the head entry opening portion sides of the supply-side and winding-side ribbon housing sections, wherein in the cartridge main body, a concave guide portion is formed, and on a bottom face of the concave guide portion, a projection portion, which comes into contact with a guide portion of the printer apparatus side, is formed.

Abstract: An information processing device includes a printer unit configured to perform a printing process, a display unit configured to display an image and display printing information including setting information of the printing process using the printer unit, a position sensor configured to output a detection signal enabling a determination of whether the information processing device is set in an image display position or a printing position, and a control unit configured to receive the detection signal from the position sensor and display the printing information on the display unit when it is determined that the information processing device is in the printing position.

Abstract: A thermal head which forms an image on a recording medium by pressing a protruding portion on which heating elements are arranged on the recording medium while driving the heating elements to be heated includes a head body portion in which the protruding portion and a concave gap portion facing the protruding portion are formed and a heat conductive layer provided on the side of the protruding portion of the head body portion, in which the heat conductive layer includes an electric insulating layer securing electric insulation to the heating elements and a heat diffusion layer diffusing heat generated from the heating elements.

Abstract: A printer device that prints an image to a printing paper using a thermal head formed with a plurality of heating resistors. The printer device includes: edge position detection means for performing edge position detection, at four corners, to an incoming printing paper using the thermal head based on a change of temperature increase observed in, as a result of energization, any of the heating resistors opposing the printing paper and the remaining heating resistors not opposing the printing paper; and control means for exercising control over an image printing operation using the thermal head based on a detection output derived by the edge position detection means.

Abstract: A thermal head includes a glass layer provided with a groove section formed inside the glass layer, a heat generating resistor disposed outside the glass layer, and a pair of electrodes provided to both sides of the heat generating resistor, wherein a part of the heat generating resistor exposed between the pair of electrodes is defined as a heat generating section, and at least one of the pair of electrodes has a smaller width in an end section on an opposite side to a side of the heat generating section than a width of an end section on the side of the heat generating section.

Abstract: A thermal head which forms an image on a recording medium by pressing a protruding portion on which heating elements are arranged on the recording medium while driving the heating elements to be heated includes a support substrate in which a concave gap portion facing the protruding portion is formed and a glaze layer provided on the support substrate and in which the protruding portion is formed, in which the glaze layer has a base layer stacked on the support substrate as well as forming a ceiling surface of the gap portion and a heat resistant layer stacked on the base layer and on which the heating elements are arranged.

Abstract: A thermal head includes a glass layer having a protruding section formed on one surface and a concave groove section formed on the other surface facing the protruding section, a heat generation resistor provided on the protruding section, and a pair of electrodes provided to both sides of the heat generation resistor, and a part of the heat generation resistor exposed between the pair of electrodes is defined as a heat generation section, the protruding section has a smaller curvature radius in both sides than a curvature radius in a central portion, and a width of the groove section is one of equal to and larger than a length of the heat generation section.

Abstract: Provided is an information processing apparatus including a printer portion performing a printing process. The printer portion has a sheet-discharge outlet for discharging a sheet, an opening-closing door for opening and closing the sheet- discharge outlet, the door performing an opening/closing operation for the sheet-discharge outlet through rotation of a rotation shaft disposed to an end portion of the door, and an opening-closing door lock mechanism that maintains the sheet-discharge outlet in a closed state by a weight of the door in the case where the information processing apparatus is set to a second position different from a first position that is a printing position of the apparatus where printing is performed by the printer portion, the second position being a position where the weight of the door is applied toward the end portion of the rotation shaft.

Abstract: An information processing device includes a printer unit configured to perform a printing process, a display unit configured to display an image and display printing information including setting information of the printing process using the printer unit, a position sensor configured to output a detection signal enabling a determination of whether the information processing device is set in an image display position or a printing position, and a control unit configured to receive the detection signal from the position sensor and display the printing information on the display unit when it is determined that the information processing device is in the printing position.

Abstract: A thermal head includes a head containing a glass layer. The glass layer has a projecting portion on one surface and a concave groove on the other surface at a position opposed to the projecting portion. The head further contains a heating resistor disposed on the projecting portion, and a pair of electrodes disposed on both sides of the heating resistor. The thermal head further includes a rigid substrate on which a control circuit for the head is provided, and a flexible substrate for electrically connecting the head and the rigid substrate.

Abstract: An ink ribbon cartridge includes: a supply spool which has at one end portion a driving hole, with which a driving shaft of a printer apparatus is engaged; a winding spool which has at one end portion a driving hole, with which the driving shaft of the printer apparatus is engaged; and a cartridge main body which has a supply-side ribbon housing section, a winding-side ribbon housing section, and a thermal head entry opening portion formed between the supply-side and winding-side ribbon housing sections, and in which opening portions for the ribbon are formed on the head entry opening portion sides of the supply-side and winding-side ribbon housing sections, wherein in the cartridge main body, a concave guide portion is formed, and on a bottom face of the concave guide portion, a projection portion, which comes into contact with a guide portion of the printer apparatus side, is formed.