Patents by Inventor Noboru Koyama

Noboru Koyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11423533
    Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: August 23, 2022
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hiroaki Kemmochi, Yasuyuki Motokui, Noboru Koyama
  • Patent number: 11176662
    Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: November 16, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hiroaki Kemmochi, Yasuyuki Motokui, Noboru Koyama
  • Publication number: 20210311024
    Abstract: An object of the present invention is to provide a non-clinical test method which allows for the quality control of experimental animals having a transplanted tumor site, such as tumor-bearing mice, or experimental animals having a lesion site other than a transplanted a tumor site, and which is characterized by including the step of identifying, using a specimen collected from such an experimental animal, the profile of a lesion site, for example, a transplanted tumor site, of the experimental animal, by a quantitative technique.
    Type: Application
    Filed: February 15, 2017
    Publication date: October 7, 2021
    Applicant: Konica Minolta, Inc.
    Inventors: Hideki GOUDA, Takeshi SHIRAISHI, Takeshi ISODA, Noboru KOYAMA, Hisatake OKADA
  • Publication number: 20210133953
    Abstract: An image processing method includes: a fluorescent image capturing step of capturing a fluorescent image of a fluorescently labeled tissue specimen; a creating step of creating a fluorescent whole slide image based on the captured fluorescent image; and a storing step of storing the created fluorescent whole slide image. The tissue specimen is fluorescently labelled by using, as a staining reagent, fluorescent substance integrated nanoparticles obtained by bonding a biological substance recognition part to fluorescent particles on which a plurality of fluorescent substances are integrated.
    Type: Application
    Filed: December 18, 2017
    Publication date: May 6, 2021
    Inventors: Hiroaki KEMMOCHI, Yasuyuki MOTOKUI, Noboru KOYAMA
  • Publication number: 20210041446
    Abstract: The present invention provides a method of obtaining information for the diagnosis or treatment, mainly of cancer or an immune system-related disease, the method including the step of quantifying the expression level of a cancer-associated protein or a nucleic acid in a tumor cell; and/or the step of quantifying the expression level of a protein or a nucleic acid in an immune cell, using a specimen derived from tumor tissue of a human or a non-human.
    Type: Application
    Filed: February 15, 2017
    Publication date: February 11, 2021
    Inventors: Masaru TAKAHASHI, Etsuko FUTAYA, Hisatake OKADA, Noboru KOYAMA
  • Publication number: 20200371106
    Abstract: Disclosed herein is a method including: acquiring one or more pieces of information including information about expression status of a specific biomarker in a lesion collected from a human by using a laboratory animal transplanted with the lesion; and using the information to estimate therapeutic efficacy through analysis
    Type: Application
    Filed: March 9, 2018
    Publication date: November 26, 2020
    Inventors: Masaru TAKAHASHI, Yasuyuki MOTOKUI, Noboru KOYAMA
  • Publication number: 20200003778
    Abstract: The present invention relates to a method for detecting an antibody-drug-conjugate and relates to a method for determining the efficacy of an antibody-drug-conjugate with high accuracy by a quantitative technique for identifying an expression level of a target molecule in a target cell of the antibody-drug-conjugate and interactions therebetween. According to the method, visualizing a drug and an antibody, or components of an antibody-drug-conjugate, by immunostaining with a phosphor integrated dot enables detection of the antibody-drug-conjugate and the components.
    Type: Application
    Filed: February 2, 2018
    Publication date: January 2, 2020
    Inventors: Masaru TAKAHASHI, Takeshi SHIRAISHI, Noboru KOYAMA
  • Publication number: 20150077686
    Abstract: A substrate for an electro-optical device includes, on a base material, a third interlayer insulation layer, a plurality of first wirings with a light shielding property which are provided on the third interlayer insulation layer, a concave portion provided in the third interlayer insulation layer (second interlayer insulation layer) of a region interposed by adjacent first wirings of the plurality of first wirings in a plan view, a protective film provided so as to cover at least the plurality of first wirings, a color filter provided in the concave portion, a second oxide film provided on the color filters and the plurality of first wirings, and a pixel electrode provided on the second oxide film.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 19, 2015
    Inventor: Noboru Koyama
  • Patent number: 8568044
    Abstract: An ink ribbon cartridge includes: a supply spool which has at one end portion a driving hole, with which a driving shaft of a printer apparatus is engaged; a winding spool which has at one end portion a driving hole, with which the driving shaft of the printer apparatus is engaged; and a cartridge main body which has a supply-side ribbon housing section, a winding-side ribbon housing section, and a thermal head entry opening portion formed between the supply-side and winding-side ribbon housing sections, and in which opening portions for the ribbon are formed on the head entry opening portion sides of the supply-side and winding-side ribbon housing sections, wherein in the cartridge main body, a concave guide portion is formed, and on a bottom face of the concave guide portion, a projection portion, which comes into contact with a guide portion of the printer apparatus side, is formed.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: October 29, 2013
    Assignee: Sony Corporation
    Inventors: Kazuyoshi Murata, Noboru Koyama, Shingo Hitose
  • Patent number: 8411315
    Abstract: An information processing device includes a printer unit configured to perform a printing process, a display unit configured to display an image and display printing information including setting information of the printing process using the printer unit, a position sensor configured to output a detection signal enabling a determination of whether the information processing device is set in an image display position or a printing position, and a control unit configured to receive the detection signal from the position sensor and display the printing information on the display unit when it is determined that the information processing device is in the printing position.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: April 2, 2013
    Assignee: Sony Corporation
    Inventors: Shingo Hitose, Noboru Koyama, Tetsuya Hoshino, Yuma Kokuzawa
  • Patent number: 8139094
    Abstract: A thermal head which forms an image on a recording medium by pressing a protruding portion on which heating elements are arranged on the recording medium while driving the heating elements to be heated includes a head body portion in which the protruding portion and a concave gap portion facing the protruding portion are formed and a heat conductive layer provided on the side of the protruding portion of the head body portion, in which the heat conductive layer includes an electric insulating layer securing electric insulation to the heating elements and a heat diffusion layer diffusing heat generated from the heating elements.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: March 20, 2012
    Assignee: Sony Corporation
    Inventors: Noboru Koyama, Mitsuo Yanase, Toru Morikawa, Kei Sato
  • Patent number: 8102409
    Abstract: A printer device that prints an image to a printing paper using a thermal head formed with a plurality of heating resistors. The printer device includes: edge position detection means for performing edge position detection, at four corners, to an incoming printing paper using the thermal head based on a change of temperature increase observed in, as a result of energization, any of the heating resistors opposing the printing paper and the remaining heating resistors not opposing the printing paper; and control means for exercising control over an image printing operation using the thermal head based on a detection output derived by the edge position detection means.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: January 24, 2012
    Assignee: Sony Corporation
    Inventors: Noboru Koyama, Tetsuya Hoshino
  • Patent number: 8098268
    Abstract: A thermal head includes a glass layer provided with a groove section formed inside the glass layer, a heat generating resistor disposed outside the glass layer, and a pair of electrodes provided to both sides of the heat generating resistor, wherein a part of the heat generating resistor exposed between the pair of electrodes is defined as a heat generating section, and at least one of the pair of electrodes has a smaller width in an end section on an opposite side to a side of the heat generating section than a width of an end section on the side of the heat generating section.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: January 17, 2012
    Assignee: Sony Corporation
    Inventors: Izumi Kariya, Noboru Koyama, Mitsuo Yanase, Tooru Morikawa
  • Patent number: 8031215
    Abstract: A thermal head which forms an image on a recording medium by pressing a protruding portion on which heating elements are arranged on the recording medium while driving the heating elements to be heated includes a support substrate in which a concave gap portion facing the protruding portion is formed and a glaze layer provided on the support substrate and in which the protruding portion is formed, in which the glaze layer has a base layer stacked on the support substrate as well as forming a ceiling surface of the gap portion and a heat resistant layer stacked on the base layer and on which the heating elements are arranged.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: October 4, 2011
    Assignee: Sony Corporation
    Inventors: Noboru Koyama, Mitsuo Yanase, Toru Morikawa, Kazunori Onuma
  • Patent number: 7907158
    Abstract: A thermal head includes a glass layer having a protruding section formed on one surface and a concave groove section formed on the other surface facing the protruding section, a heat generation resistor provided on the protruding section, and a pair of electrodes provided to both sides of the heat generation resistor, and a part of the heat generation resistor exposed between the pair of electrodes is defined as a heat generation section, the protruding section has a smaller curvature radius in both sides than a curvature radius in a central portion, and a width of the groove section is one of equal to and larger than a length of the heat generation section.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: March 15, 2011
    Assignee: Sony Corporation
    Inventors: Noboru Koyama, Izumi Kariya, Mitsuo Yanase, Toru Morikawa
  • Publication number: 20110043842
    Abstract: Provided is an information processing apparatus including a printer portion performing a printing process. The printer portion has a sheet-discharge outlet for discharging a sheet, an opening-closing door for opening and closing the sheet- discharge outlet, the door performing an opening/closing operation for the sheet-discharge outlet through rotation of a rotation shaft disposed to an end portion of the door, and an opening-closing door lock mechanism that maintains the sheet-discharge outlet in a closed state by a weight of the door in the case where the information processing apparatus is set to a second position different from a first position that is a printing position of the apparatus where printing is performed by the printer portion, the second position being a position where the weight of the door is applied toward the end portion of the rotation shaft.
    Type: Application
    Filed: August 5, 2010
    Publication date: February 24, 2011
    Applicant: Sony Corporation
    Inventors: Shingo Hitose, Noboru Koyama, Tetsuya Hoshino, Yuma Kokuzawa
  • Publication number: 20110043860
    Abstract: An information processing device includes a printer unit configured to perform a printing process, a display unit configured to display an image and display printing information including setting information of the printing process using the printer unit, a position sensor configured to output a detection signal enabling a determination of whether the information processing device is set in an image display position or a printing position, and a control unit configured to receive the detection signal from the position sensor and display the printing information on the display unit when it is determined that the information processing device is in the printing position.
    Type: Application
    Filed: August 3, 2010
    Publication date: February 24, 2011
    Applicant: Sony Corporation
    Inventors: Shingo Hitose, Noboru Koyama, Tetsuya Hoshino, Yuma Kokuzawa
  • Patent number: 7843476
    Abstract: A thermal head includes a head containing a glass layer. The glass layer has a projecting portion on one surface and a concave groove on the other surface at a position opposed to the projecting portion. The head further contains a heating resistor disposed on the projecting portion, and a pair of electrodes disposed on both sides of the heating resistor. The thermal head further includes a rigid substrate on which a control circuit for the head is provided, and a flexible substrate for electrically connecting the head and the rigid substrate.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: November 30, 2010
    Assignee: Sony Corporation
    Inventors: Tooru Morikawa, Izumi Kariya, Noboru Koyama, Mitsuo Yanase
  • Publication number: 20100272489
    Abstract: An ink ribbon cartridge includes: a supply spool, on which an ink ribbon is wound; a winding spool which takes up the ink ribbon sent from the supply spool; and a cartridge main body which has a supply-side ribbon housing section which houses the supply spool so as to be able to rotate, and a winding-side ribbon housing section which houses the winding spool so as to be able to rotate, and in which a head entry opening portion, into which a thermal head enters, is formed between the supply-side ribbon housing section and the winding-side ribbon housing section, and opening portions for the ribbon, which make the ink ribbon extend in the head entry opening portion, are formed on the head entry opening portion side of the supply-side ribbon housing section and the head entry opening portion side of the winding-side ribbon housing section.
    Type: Application
    Filed: February 19, 2010
    Publication date: October 28, 2010
    Applicant: Sony Corporation
    Inventors: Noboru Koyama, Kazuyoshi Murata, Shingo Hitose
  • Publication number: 20100272488
    Abstract: An ink ribbon cartridge includes: a supply spool which has at one end portion a driving hole, with which a driving shaft of a printer apparatus is engaged; a winding spool which has at one end portion a driving hole, with which the driving shaft of the printer apparatus is engaged; and a cartridge main body which has a supply-side ribbon housing section, a winding-side ribbon housing section, and a thermal head entry opening portion formed between the supply-side and winding-side ribbon housing sections, and in which opening portions for the ribbon are formed on the head entry opening portion sides of the supply-side and winding-side ribbon housing sections, wherein in the cartridge main body, a concave guide portion is formed, and on a bottom face of the concave guide portion, a projection portion, which comes into contact with a guide portion of the printer apparatus side, is formed.
    Type: Application
    Filed: February 19, 2010
    Publication date: October 28, 2010
    Applicant: Sony Corporation
    Inventors: Kazuyoshi Murata, Noboru Koyama, Shingo Hitose