Patents by Inventor Noboru Maki
Noboru Maki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8981073Abstract: Disclosed are an HCV gene having higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b, an RNA replicon having this gene, a cell infected with this RNA replicon, which cell allows replication of HCV, and an HCV particle. The hepatitis C virus gene encodes an amino acid sequence wherein the 979th amino acid is threonine; the 1804th amino acid is leucine; and the 1966th amino acid is lysine. An HCV gene which can propagate in vitro and has higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b was provided.Type: GrantFiled: October 7, 2011Date of Patent: March 17, 2015Assignee: Advanced Life Science Institute, Inc.Inventors: Kenichi Mori, Noboru Maki, Hiromi Fukai
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Patent number: 8741607Abstract: An HCV/GBV-B chimeric virus which maintains the replication function of HCV and is capable of infecting tamarin is disclosed in order to construct an HCV animal model which can be used as a development or evaluation system for therapeutic agents for HCV. The HCV/GBV-B chimeric RNA comprises an RNA of hepatitis C virus and an RNA of GB virus-B, wherein the RNA of hepatitis C virus comprises an RNA encoding leucine at the 1804th position and lysine at the 1966th position in the amino acid sequence of the polyprotein of hepatitis C virus.Type: GrantFiled: July 15, 2009Date of Patent: June 3, 2014Assignee: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Kenichi Mori, Hiromi Fukai
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Patent number: 8679762Abstract: [PROBLEMS] To provide a probe useful in the detection of HBV or HBs antigen by which an escape mutant of hepatitis B virus (HBV) possibly occurring in a specimen can be detected; and a method of using the same. [MEANS FOR SOLVING PROBLEMS] A probe capable of recognizing an epitope located on a peptide comprising the amino acid sequence of SEQ ID NO:1; and a method of detecting hepatitis B virus or hepatitis B virus s antigen by using this probe.Type: GrantFiled: September 21, 2005Date of Patent: March 25, 2014Assignee: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Yasuyuki Fukuda, Tatsuji Kimura, Yoko Oda, Chiharu Ohue, Osamu Kusano
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Publication number: 20130189779Abstract: Disclosed are an HCV gene having higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b, an RNA replicon having this gene, a cell infected with this RNA replicon, which cell allows replication of HCV, and an HCV particle. The hepatitis C virus gene encodes an amino acid sequence wherein the 979th amino acid is threonine; the 1804th amino acid is leucine; and the 1966th amino acid is lysine. An HCV gene which can propagate in vitro and has higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b was provided.Type: ApplicationFiled: October 7, 2011Publication date: July 25, 2013Applicant: ADVANCED LIFE SCIENCE INSTITUTE, INC.Inventors: Kenichi Mori, Noboru Maki, Hiromi Fukai
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Patent number: 8383333Abstract: There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.Type: GrantFiled: December 16, 2009Date of Patent: February 26, 2013Assignee: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Tatsuji Kimura, Shintaro Yagi
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Publication number: 20110289610Abstract: An HCV/GBV-B chimeric virus which maintains the replication function of HCV and is capable of infecting tamarin is disclosed in order to construct an HCV animal model which can be used as a development or evaluation system for therapeutic agents for HCV. The HCV/GBV-B chimeric RNA comprises an RNA of hepatitis C virus and an RNA of GB virus-B, wherein the RNA of hepatitis C virus comprises an RNA encoding leucine at the 1804th position and lysine at the 1966th position in the amino acid sequence of the polyprotein of hepatitis C virus.Type: ApplicationFiled: July 15, 2009Publication date: November 24, 2011Inventors: Noboru Maki, Kenichi Mori, Hiromi Fukai
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Publication number: 20100291546Abstract: To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that release of HBV antigens and disruption of antibodies that bind to HBV antigens are carried out by treating a sample containing HBV with a treatment agent containing (1) an acidifying agent and (2) a protein denaturant or an amphoteric surfactant or cationic surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt within a molecule.Type: ApplicationFiled: June 30, 2010Publication date: November 18, 2010Applicant: ADVANCED LIFE SCIENCE INSTITUTE, INC.Inventors: Chiharu Ohue, Noboru Maki, Tatsuji Kimura
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Publication number: 20100285444Abstract: There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.Type: ApplicationFiled: December 16, 2009Publication date: November 11, 2010Inventors: Noboru Maki, Tatsuji Kimura, Shintaro Yagi
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Publication number: 20100173298Abstract: The present invention provides a hepatitis C virus gene, a replicon RNA derived from the gene, a replicon-replicating cell into which the replicon RNA is introduced, and a method for screening a drug using the replicon-replicating cell.Type: ApplicationFiled: April 28, 2008Publication date: July 8, 2010Inventors: Kenichi Mori, Noboru Maki, Hiromi Fukai, Chiharu Ohue
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Patent number: 7713532Abstract: There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.Type: GrantFiled: September 5, 2003Date of Patent: May 11, 2010Assignee: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Tatsuji Kimura, Shintaro Yagi
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Publication number: 20090170063Abstract: A truncated form hepatitis C virus gene wherein part of the gene region encoding from the core protein to the NS2 protein of hepatitis C virus has been deleted while retaining the translation frame. In particular, the gene according to claim 1 wherein said part of the gene region is present in a region encoding at least the E1 protein and the E2 protein.Type: ApplicationFiled: June 24, 2005Publication date: July 2, 2009Inventors: Shintaro Yagi, Kenjiro Yamaguchi, Kenichi Mori, Eiji Tanaka, Kendo Kiyosawa, Noboru Maki
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Publication number: 20090017443Abstract: To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that release of HBV antigens and disruption of antibodies that bind to HBV antigens are carried out by treating a sample containing HBV with a treatment agent containing (1) an acidifying agent and (2) a protein denaturant or an amphoteric surfactant or cationic surfactant having an alkyl group and a tertiary amine or a quaternary ammonium salt within a molecule.Type: ApplicationFiled: May 19, 2005Publication date: January 15, 2009Applicant: ADVANCED LIFE SCIENCE INSTITUTE, INC.Inventors: Chiharu Ohue, Noboru Maki, Tatsuji Kimura
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Publication number: 20080193916Abstract: [PROBLEMS] To provide a probe useful in the detection of HBV or HBs antigen by which an escape mutant of hepatitis B virus (HBV) possibly occurring in a specimen can be detected; and a method of using the same. [MEANS FOR SOLVING PROBLEMS]A probe capable of recognizing an epitope located on a peptide comprising the amino acid sequence of SEQ ID NO:1; and a method of detecting hepatitis B virus or hepatitis B virus s antigen by using this probe.Type: ApplicationFiled: September 21, 2005Publication date: August 14, 2008Applicant: ADVANCED LIFE SCIENCE INSTIUTE INC.Inventors: Noboru Maki, Yasuyuki Fukuda, Tatsuji Kimura, Yoko Oda, Chiharu Ohue, Osamu Kusano
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Publication number: 20080138794Abstract: A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.Type: ApplicationFiled: September 12, 2007Publication date: June 12, 2008Inventors: Noboru Maki, Tatsuji Kimura, Yoko Oda, Shintaro Yagi
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Patent number: 7323331Abstract: A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.Type: GrantFiled: August 10, 2001Date of Patent: January 29, 2008Assignee: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Tatsuji Kimura, Yoko Oda, Shintaro Yagi
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Publication number: 20070264646Abstract: Hepatitis B virus (HBV) particles that contain HBV-RNA but do not contain HBV-DNA in a body fluid sample; A method of measuring the particles according to claim 1 by measuring HBV-RNA; A method of judging the therapeutic effect of the treatment of HBV infections by a drug having an effect of inhibiting RNA-dependent DNA polymerase, which method comprises performing the measurement on a body fluid of a patient who received said treatment; A method of predicting the risk of developing hepatic carcinoma or selecting risk groups of developing hepatic carcinoma by the above measurement.Type: ApplicationFiled: June 22, 2004Publication date: November 15, 2007Applicant: Advanced Life Science Institute, Inc.Inventors: Noboru Maki, Tatsuji Kimura, Akihiro Matsumoto, Akinori Rokuhara, Eiji Tanaka, Kendo Kiyosawa
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Publication number: 20060166187Abstract: There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.Type: ApplicationFiled: September 5, 2003Publication date: July 27, 2006Inventors: Noboru Maki, Tatsuji Kimura, Shintaro Yagi
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Publication number: 20040170953Abstract: A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.Type: ApplicationFiled: February 6, 2003Publication date: September 2, 2004Inventors: Noboru Maki, Tatsuji Kimura, Yoko Oda, Shintaro Yagi
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Patent number: 5800982Abstract: The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.Type: GrantFiled: July 24, 1996Date of Patent: September 1, 1998Assignee: Tonen CorporationInventors: Akira Hasegawa, Noboru Maki, Shintaro Yagi, Tomiko Kashiwakuma, Kenjiro Yamaguchi, Naoko Ikeguchi, Tomoko Kobayashi, Chiaki Senoo
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Patent number: 5759802Abstract: A process for the production of human serum albumin A (HSA) characterized by culturing host cells transformed with the plasmids containing a leader DNA sequence and a cDNA coding for mature HSA to produce and secrete mature HSA, and recovering the mature HSA. As the leader HSA sequence, a cDNA coding for the prepro sequence of HSA, a synthetic DNA coding for the prepro sequence of HSA, by the codons frequently used in a selected host, a DNA coding for a chimeric leader peptide, a DNA coding for MF.alpha.1 prepro sequence, or a DNA coding for PH05 signal peptide, is used.Type: GrantFiled: October 5, 1989Date of Patent: June 2, 1998Assignee: Tonen CorporationInventors: Noboru Maki, Shintaro Yagi, Kazuya Watanabe, Masanori Suzuki