Abstract: It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance.

Abstract: It is an object of the present invention to provide a pharmaceutical composition for effectively preventing or improving diseases having vascular dysfunction associated with insulin resistance. The present invention provides pharmaceutical compositions for preventing or treating diseases having vascular dysfunction associated with insulin resistance, comprising as an active ingredient a compound of the formula (I): wherein R1 and R2 each represents a hydrogen atom or taken together with each other represent a single bond, while R3 represents —CH(OH)CH(OH)CH3, —CH(OCOCH3)CH(OCOCH3)CH3, —CH3, —CH2OH or a phenyl group when R1 and R2 each represents a hydrogen atom, or —COCH(OH)CH3 when R1 and R2 together represents a single bond, or a pharmaceutically acceptable salt thereof.

Abstract: A rotor 1 forming screw teeth is projectingly provided at its outer end 2 on the axis thereof with a center shaft 3. The center shaft 3 is provided at its outer end 4 with a smaller-diameter shaft 5 or a concaved fitting hole. A separate rotor shaft 6 which is to be fitted over the smaller-diameter shaft 5 or fitted into the concaved fitting hole is provided with another concaved fitting hole 7 or smaller-diameter shaft. A metal shaft around which synthetic resin is molded is formed at its peripheral surface with a spiral groove or corrugated groove in the opposite revolutional direction with respect to the revolutional direction of the screw rotor. The spiral groove is formed with smooth arc curved line connecting profiles of adjacent grooves. The shaft is provided with a step, and synthetic resin is molded around the shaft surface to form a screw rotor.

Abstract: A rotor 1 forming screw teeth is projectingly provided at its outer end 2 on the axis thereof with a center shaft 3. The center shaft 3 is provided at its outer end 4 with a smaller-diameter shaft 5 or a concaved fitting hole. A separate rotor shaft 6 which is to be fitted over the smaller-diameter shaft 5 or fitted into the concaved fitting hole is provided with another concaved fitting hole 7 or smaller-diameter shaft. A metal shaft around which synthetic resin is molded is formed at its peripheral surface with a spiral groove or corrugated groove in the opposite revolutional direction with respect to the revolutional direction of the screw rotor. The spiral groove is formed with smooth arc curved line connecting profiles of adjacent grooves. The shaft is provided with a step, and synthetic resin is molded around the shaft surface to form a screw rotor.