Patents by Inventor Noboru Ueyama
Noboru Ueyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060246557Abstract: The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor. The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-?-hydroxy-?-butyrolactone at a temperature not lower than ?30° C.Type: ApplicationFiled: June 30, 2006Publication date: November 2, 2006Applicant: Kaneka CorporationInventors: Akira Nishiyama, Miho Horikawa, Yoshihiko Yosohara, Noboru Ueyama, Kenji Inoue
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Patent number: 7094594Abstract: The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1, 3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor. The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-?-hydroxy-?-butyrolactone at a temperature not lower than ?30° C.Type: GrantFiled: June 5, 2001Date of Patent: August 22, 2006Assignee: Kaneka CorporationInventors: Akira Nishiyama, Miho Horikawa, Yoshihiko Yasohara, Noboru Ueyama, Kenji Inoue
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Patent number: 6903225Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than ?30° C.Type: GrantFiled: September 13, 2002Date of Patent: June 7, 2005Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Publication number: 20050080277Abstract: The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment such as an ultra-low-temperature reactor. The present invention is a production process of an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative which comprises reacting an enolate, prepared by permitting a base or a 0-valent metal to act on an acetic acid ester derivative with (S)-?-hydroxy-?-butyrolactone at a temperature not lower than ?30° C.Type: ApplicationFiled: June 5, 2001Publication date: April 14, 2005Inventors: Akira Nishiyama, Miho Horikawa, Yoshihiko Yasohara, Noboru Ueyama, Kenji Inoue
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Publication number: 20040171849Abstract: The present invention provides an efficient, simple, and commercially advantageous process for producing optically active azetidine-2-carboxylic acid, which is an important material for medicines.Type: ApplicationFiled: January 14, 2004Publication date: September 2, 2004Inventors: Takeshi Kondo, Noboru Ueyama
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Publication number: 20030040634Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions.Type: ApplicationFiled: September 13, 2002Publication date: February 27, 2003Inventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Publication number: 20020169337Abstract: A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided.Type: ApplicationFiled: May 13, 2002Publication date: November 14, 2002Applicant: Kaneka CorporationInventors: Yasuyoshi Ueda, Hiroshi Murao, Takeshi Kondo, Noboru Ueyama, Hajime Manabe, Kenji Yoneda, Akira Nishiyama
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Patent number: 6472544Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions. A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than −30° C.Type: GrantFiled: August 16, 2000Date of Patent: October 29, 2002Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Yukio Yamada, Yoshihiko Yasohara, Akira Nishiyama, Makoto Miyazaki, Masaru Mitsuda, Takeshi Kondo, Noboru Ueyama, Kenji Inoue
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Patent number: 6407281Abstract: A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided.Type: GrantFiled: August 25, 2000Date of Patent: June 18, 2002Assignee: Kaneka CorporationInventors: Yasuyoshi Ueda, Hiroshi Murao, Takeshi Kondo, Noboru Ueyama, Hajime Manabe, Kenji Yoneda, Akira Nishiyama
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Patent number: 6011170Abstract: This invention relates to a method comprising reacting an amino acid derivative of the following general formula (I); ##STR1## (wherein R.sup.1 represents an amino-protective group; R.sup.0 represents hydrogen or, taken together with R.sup.1, represents an amino-protecting group; R.sup.2 represents a carboxy-protecting group; X represents a leaving group) with a thiol compound of the following general formula (II) :R.sup.3 SH (II)(wherein R.sup.3 represents an alkyl group of 1 to 7 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an aralkyl group of 7 to 10 carbon atoms) to give a cysteine derivative of the following general formula (III): ##STR2## (wherein R.sup.0, R.sup.1, R.sup.2, and R.sup.3 are as defined above), wherein the reaction is conducted in the presence of a base and water in an organic reaction solvent.Type: GrantFiled: April 22, 1999Date of Patent: January 4, 2000Assignee: Kaneka CorporationInventors: Takeshi Kondo, Akira Nishiyama, Noboru Ueyama, Hiroshi Murao, Hajime Manabe, Yasuyoshi Ueda
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Patent number: 5616726Abstract: An object of the present invention is to provide a safe method of commercially producing optically active aminoalcohol derivatives, which serve as intermediates for the synthesis of medicinal chemicals such as the immunopotentiating anticancer agent bestatin, in a simple and easy manner in high yields and with high levels of selectivity.The present invention consists in a method of producing 3-amino-1-nitro-4-phenyl-2-butanol derivatives of the general formula (1) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a hydrogen atom or an amino group protecting group, and a method of producing 3-amino-2-hydroxy-4-phenylbutyric acid derivatives derivable therefrom.Type: GrantFiled: June 21, 1995Date of Patent: April 1, 1997Assignee: Kaneka CorporationInventors: Masaru Mitsuda, Shigeo Hayashi, Junzo Hasegawa, Noboru Ueyama, Takehisa Ohashi, Masakatsu Shibasaki
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Patent number: 5565345Abstract: A process for preparing 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide having the formula (II): ##STR1## which comprises subjecting 5,6-dihydro-4-oxo-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide having the formula (I): ##STR2## to the action of a microorganism to reduce the thienothiopyran derivative having the formula (I), and collecting 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno-[2,3-b]thiopyran-7,7-dioxide having the formula (II) from the reaction mixture, wherein said microorganism belongs to the genus selected from the group consisting of Ambrosiozyma, Arthroascus, Ashbya, Candida, Cryptococcus, Hansenula, Kluyveromyces, Lipomyces, Lodderomyces, Metschnikowia, Pachysolen, Pichia, Rhodosporidium, Rhodotorula, Saccharomyces, Saccharomycopsis, Schwanniomyces, Sporidiobolus, Spolobolomyces, Stephanoascus, Trigonopsis, Trichosporon and Wingea, according to which, a simple and effective. process for preparing 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno-[2,3-b]thiopyran-7,7-dioxide.Type: GrantFiled: January 30, 1995Date of Patent: October 15, 1996Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Yoshihiko Yasohara, Yoshiko Tari, Noboru Ueyama, Junzo Hasegawa, Satomi Takahashi
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Patent number: 5214199Abstract: A malonic monoester is prepared in a good yield by a single step reaction by reacting malonic acid with an alcohol in the presence of a base and an activator of malonic acid selected from the group consisting of an acyl halide or halocarbonate and an acid anhydride or dicarbonate.Type: GrantFiled: August 30, 1991Date of Patent: May 25, 1993Assignee: Kanegafuchi Chemical Industries Co., Ltd.Inventors: Teruyoshi Koga, Noboru Ueyama, Kenji Inoue, Satomi Takahashi
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Patent number: 5214197Abstract: A novel 2,4-dihydroxyadipic acid derivative of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are the same or different and each a hydrogen atom, an alkyl group, an aralkyl group, an aryl group or a silyl group, and R.sup.2 and R.sup.3 are the same or different and each a hydrogen atom or a protective group of a hydroxy group or together form a ring, which is useful as a common intermediate in the synthesis of HMG-CoA reductase inhibitor.Type: GrantFiled: July 2, 1991Date of Patent: May 25, 1993Assignee: Kanegafuchi Chemical Industry Co., Ltd.Inventors: Shigeo Hayashi, Noboru Ueyama, Kenji Inoue, Teruyoshi Koga, Satomi Takahashi
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Patent number: 5179212Abstract: 3-Pyrrolidinol or its salt is economically produced by cyclizing an aminobutanol derivative of the formula: ##STR1## wherein R is an alkyl or a substituted or unsubstituted phenyl group, or its salt.Type: GrantFiled: November 30, 1990Date of Patent: January 12, 1993Assignee: Kanegafuchi Chemical Industry Co., Ltd.Inventors: Satomi Takahashi, Shigeo Hayashi, Naoaki Taoka, Noboru Ueyama
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Patent number: 5079382Abstract: A 3,4-epoxybutyrate of the formula: ##STR1## wherein R.sup.1 is an alkyl or aralkyl group is efficiently prepared by a process comprising steps of:(a) reacting 3,4-dihydroxybutyronitrile of the formula: ##STR2## with a sulfonyl chloride of the formula: R.sup.2 --SO.sub.2 --Cl wherein R.sup.2 is an alkyl group or a phenyl group which may be substituted in the presence of a base to obtain a compound of the formula: ##STR3## (b) reacting the compound prepared in the step (a) with an alcohol of the formula: R.sup.1 --OH in the presence of an acid to obtain a compound of the formula: ##STR4## and (c) reacting the compound prepared in the step (b) with a base to obtain the 3,4-epoxybutyrate.Type: GrantFiled: November 23, 1990Date of Patent: January 7, 1992Assignee: Kanegafuchi Chemical Industry Co., Ltd.Inventors: Naoaki Taoka, Kenji Inoue, Shigeo Hayashi, Noboru Ueyama, Satomi Takahashi
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Patent number: 5071966Abstract: A process for preparing an enol silyl ether compound from a diazoacetoacetic acid ester having the general formula (IV): ##STR1## wherein R.sup.1 is a lower alkyl group having 1 to 6 carbon atoms, phenyl group, a substituted phenyl group, an aralkyl group or allyl group, and R.sup.2, R.sup.3 and R.sup.4 are the same or mutually different and each is a lower alkyl group having 1 to 6 carbon atoms, which comprises reacting a diazoacetoacetic acid ester having the general formula (I): ##STR2## wherein R.sup.1 is the same as defined above, with a trialkylsilyl chloride having the general formula (II): ##STR3## wherein R.sup.2, R.sup.3 and R.sup.4 are the same as defined above, in an inert solvent in the presence of an organic base and an alkali halide having the general formula (III):MX (III)wherein M is an alkaline metal and X is bromine atom or iodine atom. The desired compound is useful as an intermediate for synthesis of carbapenem .beta.-lactam antibiotics.Type: GrantFiled: September 10, 1990Date of Patent: December 10, 1991Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Kazunori Kan, Hiroshi Murakami, Nobuo Nagashima, Noboru Ueyama, Takehisa Ohashi
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Patent number: 5061817Abstract: The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.Type: GrantFiled: May 31, 1988Date of Patent: October 29, 1991Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Takeisa Ohashi, Kazunori Kan, Noboru Ueyama, Isao Sada, Akimasa Miyama, Kiyoshi Watanabe
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Patent number: 4983759Abstract: A compound of a 3,5,6-trihydroxyhexanoic acid derivative of the formula: ##STR1## wherein P.sup.1 and P.sup.2 are independently hydrogen atoms or hydroxy-protecting groups, or together form a ring, and R is an alkyl group is effectively prepared by a process comprising steps of:reacting a butyronitrile derivative of the formula: ##STR2## wherein P.sup.1 and P.sup.2 are the same as defined above with an .alpha.-haloacetate of the formula:X--CH.sub.2 --COOR (III)wherein X is a halogen atom, and R is the same as defined above in the presence of a metallic catalyst selected from the group consisting zinc and zinc-copper to form a keto acid derivative of the formula: ##STR3## wherein P.sup.1, P.sup.2 and R are the same as defined above, and then reducing the obtained keto-acid derivative of the formula (IV).Type: GrantFiled: December 20, 1989Date of Patent: January 8, 1991Assignee: Kanegafuchi Chemical Industry Co., Ltd.Inventors: Kenji Inoue, Satomi Takahashi, Keiichi Yonetsu, Noboru Ueyama
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Patent number: RE36718Abstract: An object of the present invention is to provide a safe method of commercially producing optically active aminoalcohol derivatives, which serve as intermediates for the synthesis of medicinal chemicals such as the immunopotentiating anticancer agent bestatin, in a simple and easy manner in high yields and with high levels of selectivity.The present invention consists in a method of producing 3-amino-1-nitro-4-phenyl-2-butanol derivatives of the general formula (1) ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a hydrogen atom or an amino group protecting group, and a method of producing 3-amino-2-hydroxy-4-phenylbutyric acid derivatives derivable therefrom.Type: GrantFiled: March 30, 1999Date of Patent: May 30, 2000Assignee: Kaneka CorporationInventors: Masaru Mitsuda, Shigeo Hayashi, Junzo Hasegawa, Noboru Ueyama, Takehisa Ohashi, Masakatsu Shibasaki