Patents by Inventor Noboru Yamaji
Noboru Yamaji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080119404Abstract: An antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent comprising an angiopoietin-related growth factor (AGF) or a polynucleotide encoding the same as an active ingredient a polypeptide are disclosed. Further, a functional food or a health food for alleviating obesity, diabetes, and/or hyperlipemia, comprising the AGF as an active ingredient is disclosed. Furthermore, a method for treating or preventing obesity, diabetes, and/or hyperlipemia, comprising administering to a subject the AGF or a polynucleotide encoding the same is disclosed. Furthermore, use of the AGF or a polynucleotide encoding the same in the manufacture of an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent is disclosed.Type: ApplicationFiled: March 30, 2005Publication date: May 22, 2008Applicant: Astellas Pharma Inc.Inventors: Kunio Yasunaga, Noboru Yamaji, Toshio Suda, Yuichi Oike
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Patent number: 7374923Abstract: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.Type: GrantFiled: November 7, 2006Date of Patent: May 20, 2008Assignee: Astellas Pharma Inc.Inventors: Kunitake Abe, Masayoshi Takeda, Noboru Yamaji, Miyuki Katou, Tetsuo Matsui
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Publication number: 20080102459Abstract: The present invention relates to a method of screening for an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent, comprising the step of analyzing whether or not a substance to be tested promotes an expression and/or a function of an angiopoietin-related growth factor. The present invention relates to a method of screening for an agent for promoting an expression and/or a function of an angiopoietin-related growth factor.Type: ApplicationFiled: December 1, 2005Publication date: May 1, 2008Applicants: ASTELLAS PHARMA INC., KEIO UNIVERSITYInventors: Kunio Yasunaga, Noboru Yamaji, Kunitake Abe, Yuichi Oike
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Publication number: 20070077591Abstract: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.Type: ApplicationFiled: November 7, 2006Publication date: April 5, 2007Inventors: Kunitake Abe, Masayoshi Takeda, Noboru Yamaji, Miyuki Katou, Tetsuo Matsui
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Patent number: 7193073Abstract: A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed. The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).Type: GrantFiled: November 23, 2005Date of Patent: March 20, 2007Assignee: Astellas Pharma Inc.Inventors: Noboru Yamaji, Kouichi Nishimura, Kunitake Abe
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Patent number: 7157567Abstract: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.Type: GrantFiled: February 19, 2003Date of Patent: January 2, 2007Assignee: Astellas Pharma, Inc.Inventors: Kunitake Abe, Noboru Yamaji, Miyuki Katou, Tetsuo Matsui
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Patent number: 7091007Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.Type: GrantFiled: June 23, 2003Date of Patent: August 15, 2006Assignee: Genetics Institute, LLCInventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
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Publication number: 20060172296Abstract: It is disclosed that novel polypeptides which has enhanced expression levels in the synovial tissues of human chronic rheumatoid arthritis (RA) patients compared with the synovial tissues of human osteoarthritis (OA) patients, polynucleotides encoding the polypeptides, vectors comprising the polynucleotides, transformant cells comprising the vectors and an antibody against the polypeptide. It is also disclosed that polynucleotides specifically hybridizing with the polynucleotides and having at least 15 nucleotides, a detection method which is useful for RA diagnosis, and a detection kit which is useful for RA diagnosis.Type: ApplicationFiled: July 18, 2003Publication date: August 3, 2006Inventors: Masahiro Takeuchi, Noboru Yamaji, Jun Takasaki, Masahiko Akamatsu, Kazuhisa Tsunoyama, Masayoshi Harigai
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Publication number: 20060134719Abstract: It is disclosed that a novel polypeptide useful for screening for an agent for specific diseases to which gastrointestinal hormones are related, particularly irritable bowel syndrome, a polynucleotide encoding the polypeptide, a vector comprising the polynucleotide, and a transfected cell by the vector. It is disclosed that the polypeptide is a novel type II transmembrane serine protease related to the regulation of hormones produced in gastrointestinal tract or a precursor thereof. Additionally, a screening method of an agent for gastrointestinal diseases using the polypeptide and a method for producing a pharmaceutical composition for the treatment of gastrointestinal diseases, comprising a substance obtained by the screening method as the active ingredient are disclosed.Type: ApplicationFiled: July 30, 2003Publication date: June 22, 2006Inventors: Masayoshi Takeda, Noboru Yamaji
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Publication number: 20060014931Abstract: Disclosing a promoter of the protease MDTS9, which is induced by TGF-?, which is involved in the metabolism of extracellular matrix, and in which the expression of the gene thereof is elevated in renal failure model animals, which promoter is useful as a tool for screening an agent for treating and/or preventing chronic renal failure, as well as a method for screening an agent for treating and/or preventing chronic renal failure by selecting an inhibitor of the promoter.Type: ApplicationFiled: June 19, 2003Publication date: January 19, 2006Inventors: Masayoshi Takeda, Kunitake Abe, Noboru Yamaji
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Publication number: 20050272647Abstract: An agent for inhibiting articular cartilage extracellular matrix degradation of the present invention, comprising a histone deacetylase-inhibiting compound as an active ingredient, is effective for the prevention and treatment of diseases and pathological conditions involving the degradation and degeneration of the articular cartilage extracellular matrix, in particular, arthrosteitis, rheumatic arthritis, osteoarthritis, and the like.Type: ApplicationFiled: August 19, 2003Publication date: December 8, 2005Inventors: Noboru Yamaji, Nobuaki Shindou, Yoh Terada
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Publication number: 20040241778Abstract: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.Type: ApplicationFiled: March 31, 2004Publication date: December 2, 2004Inventors: Kunitake Abe, Masayoshi Takeda, Noboru Yamaji, Miyuki Katou, Tetsuo Matsui
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Publication number: 20040142445Abstract: This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.Type: ApplicationFiled: January 26, 2004Publication date: July 22, 2004Applicants: YAMANOUCHI PHARMACEUTICAL CO., LTD., KAZUSA DNA RESEARCH INSTITUTEInventors: Noboru Yamaji, Kouichi Nishimura, Kunitake Abe, Osamu Ohara, Takahiro Nagase, Nobuo Nomura
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Publication number: 20040142417Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.Type: ApplicationFiled: June 23, 2003Publication date: July 22, 2004Applicant: Genetics Institute, LLC.Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
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Patent number: 6716613Abstract: This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.Type: GrantFiled: December 10, 2001Date of Patent: April 6, 2004Assignees: Yamanouchi Pharmaceutical Co., Ltd., Kazusa DNA Research InstituteInventors: Noboru Yamaji, Kouichi Nishimura, Kunitake Abe, Osamu Ohara, Takahiro Nagase, Nobuo Nomura
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Publication number: 20030185828Abstract: A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed.Type: ApplicationFiled: October 2, 2002Publication date: October 2, 2003Inventors: Noboru Yamaji, Kouichi Nishimura, Kunitake Abe
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Patent number: 6610513Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.Type: GrantFiled: June 5, 2001Date of Patent: August 26, 2003Assignee: Genetics Institute, LLC.Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
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Publication number: 20030129658Abstract: A novel polypeptide, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell transfected with the expression vector, an antibody or a fragment thereof binding to the polypeptide, and a process for producing the polypeptide are disclosed.Type: ApplicationFiled: November 26, 2002Publication date: July 10, 2003Inventors: Noboru Yamaji, Kouichi Nishimura, Kunitake Abe, Makoto Ogino
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Publication number: 20020137133Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.Type: ApplicationFiled: June 5, 2001Publication date: September 26, 2002Applicant: Genetics Institute, Inc.Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji
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Patent number: 6291206Abstract: Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.Type: GrantFiled: September 17, 1993Date of Patent: September 18, 2001Assignee: Genetics Institute, Inc.Inventors: John M. Wozney, Anthony J. Celeste, R. Scott Thies, Noboru Yamaji