Patents by Inventor Nobuaki Koike

Nobuaki Koike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210268541
    Abstract: An object of the present invention is to provide a method for producing a coated material by using a composition that can be spray-coated, and that does not run downward after coating (i.e., rheology controllable). The method for producing a coated material includes step (1) of applying an electron beam-curable composition containing an ethylenically unsaturated group-containing compound to a substrate to form a coating film that has a surface viscosity of 1 Pa·s to 300 Pa·s as measured based on an electric-field pickup method, step (2) of drying the coating film obtained in step (1) to form a dry coating film when the electron beam-curable composition contains a volatile component, and step (3) of irradiating the substrate that has the coating film obtained in step (1) or the dry coating film obtained in step (2) with electron beams in an inert gas atmosphere to form a cured coating film.
    Type: Application
    Filed: December 21, 2020
    Publication date: September 2, 2021
    Applicants: TOAGOSEI CO., LTD., TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Eiichi Okazaki, Kazuki Ofusa, Katsunobu Mochizuki, Shinya Kanbe, Nobuaki Koike, Keiji Ambo, Atsuo Nabeshima, Mamoru Kouzaki, Shuji Yomo, Kanji Mori
  • Patent number: 5789407
    Abstract: The present invention relates to an antidepressant containing as an active ingredient a triazine derivative or a pharmaceutically acceptable salt thereof, the derivative being represented by the following Formula (I): ##STR1## in which, R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkanoyl; R.sup.2 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, or a substituted or unsubstituted heterocyclic group; R.sup.3 represents a substituted or unsubstituted heterocyclic group; X represents a single bond, O, S, S(O), S(O).sub.2, or NR.sup.4 (in which R.sup.4 represents hydrogen, or substituted or unsubstituted lower alkyl; or R.sup.2 and NR.sup.4 are combined to form a substituted or unsubstituted 4 to 6-membered saturated heterocyclic group); and A represents N or CR.sup.5 (in which R.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: August 4, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Nobuaki Koike, Junichi Shimada, Shigeto Kitamura, Shunji Ichikawa, Joji Nakamura, Shizuo Shiozaki
  • Patent number: 5703085
    Abstract: The present invention relates to novel xanthine derivatives and pharmaceutically acceptable salts thereof, represented by Formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent hydrogen, lower alkyl, lower alkenyl, or lower alkynyl, R.sup.4 represents lower alkyl, or substituted or unsubstituted aryl, R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, and lower alkoxy, or R.sup.5 and R.sup.6 are combined together to represent --O--(CH.sub.2)p--O-- (p is an integer of 1 to 3), n represents 0, 1, or 2, and m represents 1 or 2.The compounds of the present invention have an adenosine A.sub.2 receptor antagonistic activity, and are useful for the treatment or prevention of various kinds of diseases caused by hyperergasia of adenosine A.sub.2 receptors (for example, Parkinson's disease, senile dementia, depression, asthma, and osteoporosis).
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: December 30, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Nobuaki Koike, Junichi Shimada, Joji Nakamura, Shizuo Shiozaki, Shigeto Kitamura, Shunji Ichikawa, Hiroshi Kase, Hiromi Nonaka
  • Patent number: 5670498
    Abstract: Disclosed are xanthine derivatives represented by the following Formula (I): ##STR1## in which R.sup.1, R.sup.2, and R.sup.3 independently represent hydrogen or lower alkyl;Q.sup.1, Q.sup.2, and Q.sup.3 independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;and X represents --COR.sup.4 (in which R.sup.4 represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or --SO.sub.2 R.sub.5 {in which R.sup.5 represents hydroxy, lower alkoxy, trifluoromethyl, ##STR2## in which R.sup.6 and R.sup.7 independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or ##STR3## (in which m represents an integer of 1 to 3; and R.sup.8 and R.sup.9 independently represent hydrogen or lower alkyl), or ##STR4## (in which Y represents a single bond, oxygen, or N--R.sup.10 in which R.sup.10 represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3)}, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: September 23, 1997
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Hiroshi Kase, Joji Nakamura, Shizuo Shiozaki, Hiromi Nonaka
  • Patent number: 5587378
    Abstract: Methods for the treatment of Parkinson's disease comprising administering to a patient an agent which contains, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 is cycloalkyl, --(CH.sub.2).sub.n --R.sup.5, wherein R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4, or ##STR2## wherein Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z is substituted or unsubstituted aryl, ##STR3## wherein R.sup.6 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m is an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 are independently O or S.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 24, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Joji Nakamura, Shizuo Shiozaki, Shunji Ichikawa, Akio Ishii, Hiromi Nonaka
  • Patent number: 5565460
    Abstract: The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound being represented by the following Formula (I): ##STR1## and A represents N or CR.sup.5 (in which R.sup.5 represents hydrogen, or substituted or unsubstituted lower alkyl), or represented by the following Formula (II): ##STR2## wherein Y, R.sup.6 and R.sup.8 are as defined herein and B and the adjacent two carbon atoms are combined to form a substituted or unsubstituted, partially saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic group.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: October 15, 1996
    Assignee: Kyowa Hakko Koygo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Shunji Ichikawa, Joji Nakamura, Tomoyuki Kanda, Shigeto Kitamura
  • Patent number: 5543415
    Abstract: The present invention relates to an antidepressant containing as an active ingredient a xanthine derivative or a pharmaceutically acceptable salt thereof, the xanthine derivative being represented by Formula (I) : ##STR1## in which R.sup.1, R.sup.2, and R.sup.3 represent independently hydrogen, lower alkyl, lower alkenyl;R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## (in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## (in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 3), or a substituted or unsubstituted heterocyclic group);and X.sup.1 and X.sup.2 represent independently O or S.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: August 6, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Akio Ishii, Joji Nakamura, Shunji Ichikawa, Shigeto Kitamura, Nobuaki Koike
  • Patent number: 5484920
    Abstract: Agents for the treatment of Parkinson's disease contain, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## in which R.sup.1, R.sup.2 are R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 represent independently O or S.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: January 16, 1996
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Fumio Suzuki, Junichi Shimada, Nobuaki Koike, Joji Nakamura, Shizuo Shioazaki, Shunji Ichikawa, Akio Ishii, Hiromi Nonaka
  • Patent number: 5477053
    Abstract: This invention relates to a radiographic intensifying screen excellent in sharpness and durability, which comprises a support, a fluorescent layer formed on the support, and a protective layer formed by coating a solution containing a protective layer-forming resin on the fluorescent layer, wherein a water repellent layer or a resin layer which may optionally contain a water repellent is provided between the fluorescent layer and the protective layer, or the fluorescent layer may optionally contain a water repellent, and also relates to a process for preparing the same.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: December 19, 1995
    Assignee: Kasei Optonix, Ltd.
    Inventors: Akio Umemoto, Yujiro Suzuki, Tutomu Watanabe, Michio Tanaka, Nobuaki Koike