Patents by Inventor Nobuaki Taniguchi
Nobuaki Taniguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130197009Abstract: [Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation [Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.Type: ApplicationFiled: October 21, 2011Publication date: August 1, 2013Applicant: ASTELLAS PHARMA INC.Inventors: Yukitaka Ideyama, Sadao Kuromitsu, Takashi Furutani, Masayoshi Takeda, Satoshi Konagai, Tomohiro Yamada, Nobuaki Taniguchi, Yutaka Kondoh, Masaaki Hirano, Kazushi Watanabe, Takashi Sugane, Akio Kakefuda
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Patent number: 7666873Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: GrantFiled: September 26, 2007Date of Patent: February 23, 2010Assignee: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Takenori Kimura, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Publication number: 20080214543Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: ApplicationFiled: September 26, 2007Publication date: September 4, 2008Applicant: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Patent number: 7297698Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: GrantFiled: July 11, 2003Date of Patent: November 20, 2007Assignee: Astellas Pharma Inc.Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Takenori Kimura, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Publication number: 20050261303Abstract: The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.Type: ApplicationFiled: July 11, 2003Publication date: November 24, 2005Inventors: Nobuaki Taniguchi, Masakazu Imamura, Masahiko Hayakawa, Kenichi Kawaguchi, Takenori Kimura, Isao Kinoyama, Hiroyuki Kaizawa, Minoru Okada, Takashi Furutani
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Publication number: 20050090498Abstract: There is provided medicaments, particularly a vascular endothelial growth factor (VEGF) inhibitor which is useful as a therapeutic drug for solid tumors, diabetic retinopathy and the like diseases in which angiogenesis is taking a role. That is, since a novel 3-quinolin-2(1H)-ylideneindolin-2-one derivative or a salt thereof has good VEGF inhibitory action, angiogenesis inhibitory action and anti-tumor action, it is useful as ideal VEGF inhibitor, angiogenesis inhibitor and anti-tumor agent.Type: ApplicationFiled: May 23, 2002Publication date: April 28, 2005Inventors: Kiyohiro Samizu, Hiroyuki Hisamichi, Akira Matsuhisa, Isao Kinoyama, Masahiko Hayakawa, Nobuaki Taniguchi, Yukitaka Ideyama, Sadao Kuromitsu, Kiyoshi Yahiro, Minoru Okada
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Publication number: 20040010037Abstract: This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.Type: ApplicationFiled: June 30, 2003Publication date: January 15, 2004Applicant: YAMANOUCHI PHARMACEUTICAL CO., LTD.Inventors: Nobuaki Taniguchi, Isao Kinoyama, Takashi Kamikubo, Akira Toyoshima, Kiyohiro Samizu, Eiji Kawaminami, Masakazu Imamura, Hiroyuki Moritomo, Akira Matsuhisa, Masaaki Hirano, Yoji Miyazaki, Eisuke Nozawa, Minoru Okada, Hiroshi Koutoku, Mitsuaki Ohta
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Patent number: 6673799Abstract: This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.Type: GrantFiled: March 21, 2001Date of Patent: January 6, 2004Assignee: Yamanouchi Pharmaceutical Co. Ltd.Inventors: Nobuaki Taniguchi, Isao Kinoyama, Takashi Kamikubo, Akira Toyoshima, Kiyohiro Samizu, Eiji Kawaminami, Masakazu Imamura, Hiroyuki Moritomo, Akira Matsuhisa, Masaaki Hirano, Yoji Miyazaki, Eisuke Nozawa, Minoru Okada, Hiroshi Koutoku, Mitsuaki Ohta
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Patent number: 5856564Abstract: This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group,A: a single bond; a group represented by the formula --NHCO--(CR.sup.3 R.sup.4).sub.n --,n: 0 or an integer of from 1 to 3,R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.Type: GrantFiled: November 18, 1997Date of Patent: January 5, 1999Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Akihiro Tanaka, Hiroyuki Koshio, Nobuaki Taniguchi, Akira Matsuhisa, Ken-ichiro Sakamoto, Atsuki Yamazaki, Takeyuki Yatsu
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Patent number: 5723606Abstract: This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group,A: a single bond; a group represented by the formula--NHCO--(CR.sup.3 R.sup.4).sub.n --,n: 0 or an integer of from 1 to 3,R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.Type: GrantFiled: January 19, 1996Date of Patent: March 3, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Akihiro Tanaka, Hiroyuki Koshio, Nobuaki Taniguchi, Akira Matsuhisa, Ken-ichiro Sakamoto, Atsuki Yamazaki, Takeyuki Yatsu
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Patent number: 5710150Abstract: Benzazepine derivatives represented by the following general formula (I) useful as arginine vasopressin antagonists or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and difluorobenzazepinone derivatives represented by the following general formulae (II) and (III) which are useful as production intermediates of the compound (I).Type: GrantFiled: February 26, 1996Date of Patent: January 20, 1998Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Nobuaki Taniguchi, Akihiro Tanaka, Akira Matsuhisa, Ken-ichiro Sakamoto, Hiroyuki Koshio, Takeyuki Yatsu