Patents by Inventor Nobue Kikuchi

Nobue Kikuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 16-membered macrolide derivatives
    Patent number: 5602106
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R.sup.4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof are disclosed.A novel process for producing these 16-membered macrolide derivatives is also disclosed.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: February 11, 1997
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Osamu Hara, Ken-ichi Kurihara, Nobue Kikuchi, Minako Araake, Akira Shimizu, Tsuneo Okonogi, Shigeharu Inouye, Seiji Shibahara
  • 16-membered macrolide derivatives and process for producing the same
    Patent number: 5519122
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms;and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: May 21, 1996
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Ken-ichi Kurihara, Akira Shimizu, Shuichi Gomi, Nobue Kikuchi, Minako Araake, Tsuneo Ishizuka, Aiko Miyata, Osamu Hara, Seiji Shibahara
  • 16-membered macrolide derivatives and process for producing the same
    Patent number: 5407918
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: April 18, 1995
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Ken-ichi Kurihara, Akira Shimizu, Shuichi Gomi, Nobue Kikuchi, Minako Araake, Tsuneo Ishizuka, Aiko Miyata, Osamu Hara, Seiji Shibahara