Patents by Inventor Nobufumi Kawai

Nobufumi Kawai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6573243
    Abstract: The present invention provides a peptide represented by the amino acid sequence formula (A): H-X1-X2-X3-X4-Gly-X6-X7-Asp-Gln-R  (A) wherein: each of X1 and X3 independently represents Arg or Lys, each of X2, X4 and X6 independently represents Ile or Leu, and X7 represents Phe, Tyr or Trp; and R represents -NH2, -Leu-NH2, -Leu-Ser-NH2, -Leu-Ser-Lys-NH2, -Leu-Ser-Arg-NH2, -Leu-Ser-Lys-Leu-NH2, or -Leu-Ser-Arg-Leu-NH2; and a salt thereof. (In the above, Gly stands for a glycine residue, Asp stands for an aspartic acid residue, Gln stands for a glutamine residue, Arg stands for an arginine residue, Lys stands for a lysine residue, Ile stands for an isoleucine residue, Leu stands for a leucine residue, Phe stands for a phenylalanine residue, Tyr stands for a tyrosine residue, Trp stands for a tryptophan residue, and Ser stands for a serine residue.) The peptide acts on glutamate receptors and is expected to be useful in the treatment of cerebral nerve diseases associated with glutamic acid.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 3, 2003
    Assignee: Suntory Limited
    Inventors: Yasuhiro Itagaki, Katsuhiro Konno, Nobufumi Kawai, Hiroaki Takayama
  • Patent number: 5246968
    Abstract: A compound having glutamate receptor inhibitor activity represented by the formula: ##STR1## where R represents a hydrogen atom or a group of the formula: ##STR2## m and n each represents an integer of 3 or 4 and p represents an integer of 0 or 1, or a salt thereof is provided. The compounds are useful for an insecticide.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 21, 1993
    Assignees: Takeda Chimical Industries, Ltd., Tokyo Metropolitan Institute for Neurosciences
    Inventors: Terumi Nakajima, Yoshio Aramaki, Tadashi Yasuhara, Tsutomu Higashijima, Nobufumi Kawai, Akiko Miwa, Masanori Yoshioka
  • Patent number: 4918107
    Abstract: A compound of the formula ##STR1## wherein R' is hydrogen atom or an alkyl group, m is an integer of 1 to 3, p is 1 or 2, x is an integer of 2 to 6, and y is an integer of 1 to 3, or a salt thereof, which has glutamate receptor inhibitor activity, a process for preparing the same and an insecticidal composition containing the same are provided.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: April 17, 1990
    Assignees: Tsumura & Co., Tokyo Metropolitan Institute for Neurosciences, Takeda Chemical Industries, Ltd.
    Inventors: Terumi Nakajima, Nobufumi Kawai, Koichi Shudo, Tetsuo Shiba
  • Patent number: 4855405
    Abstract: A novel glutamate receptor inhibitor obtained from Joro spider venom glands, and its manufacturing method.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: August 8, 1989
    Assignees: Tokyo Metropolitan Institute for Neurosciences, Takeda Chemical Industries, Ltd.
    Inventors: Masanori Yoshioka, Hidemitsu Hou, Nobufumi Kawai