Patents by Inventor Nobuharu Shigematsu

Nobuharu Shigematsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor
    Patent number: 6110933
    Abstract: The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: August 29, 2000
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Nobuharu Shigematsu, Seiji Yoshimura, Satoshi Okada, Keiji Hemmi, deceased, Hirokazu Tanaka, Takanao Otsuka, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Naoki Fukami
  • Cyclic peptide nuclei and derivatives thereof
    Patent number: 5952299
    Abstract: New peptide compounds of the formula: ##STR1## wherein R.sup.1 is alkyl or aralkyl,R.sup.2 is amino(lower)alkyl or protected amino(lower)alkyl,R.sup.3 is hydroxy, protected hydroxy, amino or protected amino,R.sup.4 is hydroxy, orR.sup.3 and R.sup.4 are linked together to form --Z-- (in which --Z-- is --O-- or --NH--), andR.sup.5 is hydrogen or an amino protective group,R.sup.6 is hydroxy, orR.sup.5 and R.sup.6 are linked together to form bond,with proviso thatwhenR.sup.3 is hydroxy, protected hydroxy, amino or protected amino andR.sup.4 is hydroxy,then R.sup.5 and R.sup.6 are linked together to form bond,and a pharmaceutically acceptable salt thereof, which is useful as a medicament.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: September 14, 1999
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michizane Hashimoto, Nobuharu Shigematsu, Seiji Hashimoto
  • Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases
    Patent number: 5502033
    Abstract: A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: March 26, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara
  • Process for producing WS-9326A and WS-9326B
    Patent number: 5436140
    Abstract: The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: July 25, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • Polypeptide compound and a process for preparation thereof
    Patent number: 5376634
    Abstract: A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,R.sup.3 is hydroxysulfonyloxy, andR.sup.4 is hydrogen or carbamoyl,with proviso thatR.sup.1 is not palmitoyl, when R.sup.2 is hydroxy,R.sup.3 is hydroxysulfonyloxy andR.sup.4 is carbamoyl,and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: December 27, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki
  • WS7622A mono- or di-sulfate, process for preparation thereof and use thereof
    Patent number: 5364624
    Abstract: A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: November 15, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • WS7622A mono- or di- sulfate, process for preparation thereof and use thereof
    Patent number: 5292510
    Abstract: WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: March 8, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis
    Patent number: 5279826
    Abstract: A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: January 18, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Noriaki Inamura, Yasuhiko Shinguh, Kunio Nakahara, Yoshitada Notsu, Masanori Okamoto, Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Nobuharu Shigematsu, Masakuni Okuhara
  • Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof
    Patent number: 5217952
    Abstract: This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.
    Type: Grant
    Filed: November 20, 1991
    Date of Patent: June 8, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome
    Patent number: 5167958
    Abstract: A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 1, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof
    Patent number: 5021240
    Abstract: The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.
    Type: Grant
    Filed: February 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • FR901228 substance and preparation thereof
    Patent number: 4977138
    Abstract: The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: December 11, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Toshio Goto, Yasuhiro Hori, Takashi Fujita, Hirotsugu Ueda, Nobuharu Shigematsu
  • Use of the polypeptide compound
    Patent number: H1638
    Abstract: A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hydrogen or hydroxy, with the proviso that (i) R.sup.2 is acyloxy when R.sup.3 is hydrogen, and (ii) R.sup.5 is hydrogen when R.sup.6 is hydrogen, or a pharmaceutically acceptable salt thereof, is useful in the prevention or treatment of Pneumocystis carinii infection.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: March 4, 1997
    Inventors: Takahisa Furuta, Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara