Patents by Inventor Nobuhiko Kamoshita

Nobuhiko Kamoshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV Vector for Disrupting Coagulation Factor-Related Gene on Liver Genome
    Publication number: 20230190958
    Abstract: The present invention provides a recombinant adeno-associated virus (rAAV) vector for treating a blood coagulation-related disease to provide a novel gene therapy means for hemophilia. The virus vector comprises a virus genome comprising a liver-specific promoter sequence and a polynucleotide sequence encoding a genome editing means operably linked to the promoter sequence, wherein the genome editing means is (a) a means comprising CRISPR/Cas9 composed of a Cas9 protein and a guide RNA (gRNA) and a repair gene, or (b) a means comprising CRISPR/Cas9 composed of a Cas9 protein and a gRNA, and the gRNA comprises a nucleotide region complementary to a part of a region related to expression of a disease-related protein on the genome of a patient and a region that interacts with the Cas9 protein.
    Type: Application
    Filed: January 9, 2018
    Publication date: June 22, 2023
    Applicant: Jichi Medical University
    Inventors: Tsukasa Ohmori, Yasumitsu Nagao, Hiroaki Mizukami, Asuka Sakata, Keiya Ozawa, Shin-ichi Muramatsu, Shin-ichi Tominaga, Yutaka Hanazono, Satoshi Nishimura, Yoichi Sakata, Nobuhiko Kamoshita