Patents by Inventor Nobuhiko Komatsu

Nobuhiko Komatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof
    Patent number: 4309437
    Abstract: Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2-acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding 11-reactive compound with a reactive sulfur compound to form 11-sulfino compounds and, if desired, oxidizing the 11-sulfino compounds to obtain 11-sulfo compound.
    Type: Grant
    Filed: March 4, 1980
    Date of Patent: January 5, 1982
    Assignee: The Green Cross Corporation
    Inventors: Yasuo Ueda, Yoshio Kagitani, Eiji Sako, Tadakazu Suyama, Nobuhiko Komatsu, Daisuke Satoh
  • Pyrrolo benzodiazepine compounds
    Patent number: 4239683
    Abstract: Novel perhydro-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one compounds having antitumor activity, perhydro-1H-pyrrolo[2,1-C][1,4]-benzodiazepin-5,11-dione, compounds which are synthetic intermediate of the former, and processes for producing these compounds.
    Type: Grant
    Filed: May 25, 1979
    Date of Patent: December 16, 1980
    Assignee: The Green Cross Corporation
    Inventors: Atuyuki Takanabe, Yoshio Arakawa, Yoshio Kagitani, Yasuo Ueda, Daisuke Satoh, Nobuhiko Komatsu
  • Pyrrolo benzodiazepine compounds
    Patent number: 4185016
    Abstract: Novel perhydro-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one compounds having antitumor activity, perhydro-1H-pyrrolo[2,1-C][1,4]-benzodiazepin-5,11-dione compounds which are synthetic intermediate of the former, and processes for producing these compounds.
    Type: Grant
    Filed: October 2, 1978
    Date of Patent: January 22, 1980
    Assignee: The Green Cross Corporation
    Inventors: Atuyuki Takanabe, Yoshio Arakawa, Yoshio Kagitani, Yasuo Ueda, Daisuke Satoh, Nobuhiko Komatsu
  • Method of producing neoschizophyllan having novel pharmacological activity
    Patent number: 4098661
    Abstract: Neoschizophyllan is produced by an ultrasonication of Schizophyllan which is extracted from a culture solution of Schizophyllum commune Fries or a fruit body thereof.
    Type: Grant
    Filed: October 19, 1976
    Date of Patent: July 4, 1978
    Assignees: Taito Co., Ltd., Kaken Chemical Co., Ltd.
    Inventors: Syoichi Kikumoto, Osamu Yamamoto, Nobuhiko Komatsu, Haruhiko Kobayashi, Teruo Kamasuka
  • Process for producing antitumor compound
    Patent number: 4011140
    Abstract: A process for producing 5, 10, 11, 11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo-[2,1-C][1,4]benzod iazepin-2-acrylamide, which comprises aerobicatlly culturing Streptomyces spadicogriseus KOMATSU, FERM P-3275, ATCC 31179, belonging to the genus Streptomyces to produce said compound in the nutrient medium, and recovering said compound from the medium. The compound thus obtained has an excellent antitumor activity.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: March 8, 1977
    Assignee: The Green Cross Corporation
    Inventor: Nobuhiko Komatsu
  • Treatment of tumors with glucan compositions in mice and rats
    Patent number: 3987166
    Abstract: A treatment of malignant tumors by administration of therapeutic compositions comprising the chemical compound "glucan".
    Type: Grant
    Filed: May 22, 1972
    Date of Patent: October 19, 1976
    Assignees: Kaken Kagaku Kabushiki Kaisha, Taito Co., Ltd.
    Inventors: Nobuhiko Komatsu, Sumio Sakai, Gosaku Saito, Syoichi Kikumoto, Keitaro Kimura
  • Treatment of bacterial infections with glucan compositions
    Patent number: 3943247
    Abstract: Prevention and therapeutics of bacterial infections based on the activation of the reticuloendothelial system with glucan having .beta.-1, 3-linkage in the main chain, the derivatives and partially hydrolysed product thereof.
    Type: Grant
    Filed: July 11, 1973
    Date of Patent: March 9, 1976
    Assignees: Kaken Kagaku Kabushiki Kaisha, Taito Co., Ltd.
    Inventors: Nobuhiko Komatsu, Sumio Sakai, Gosaku Saito, Syoichi Kikumoto, Keitaro Kimura