Patents by Inventor Nobuhiko Maiya

Nobuhiko Maiya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10990798
    Abstract: An analysis device includes: a cell image acquisition unit that acquires a plurality of cell images in which a stimulated cell has been captured; a feature value calculation unit that calculates a feature value for each of first and second constituent elements constituting the cell, from the cell images acquired by the cell image acquisition unit; a correlation calculation unit that calculates correlations between first feature values and between second feature values in the first and second constituent elements calculated by the feature value calculation unit; a correlation extraction unit that extracts the correlation between the first feature values by selecting the first feature values with respect to the correlations between the feature values in the first and second constituent elements calculated by the correlation calculation unit; and a display unit that displays the correlation between the first feature values extracted by the correlation extraction unit.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: April 27, 2021
    Assignees: THE UNIVERSITY OF TOKYO, NIKON CORPORATION
    Inventors: Masayuki Murata, Fumi Kano, Yoshiyuki Noguchi, Hirotada Watanabe, Nobuhiko Maiya, Shinichi Furuta, Takuro Saigo, Mamiko Masutani, Masafumi Yamashita, Shoko Yamasaki
  • Patent number: 10796130
    Abstract: An image processing apparatus includes a cell image acquisition unit configured to acquire a cell image captured with cells, a characteristic amount calculation unit configured to calculate a plurality of types of characteristic amounts on the cell image acquired by the cell image acquisition unit, and a correlation extraction unit configured to extract specific correlations from among a plurality of correlations among the characteristic amounts calculated by the characteristic amount calculation unit, based on likelihood of the characteristic amounts.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: October 6, 2020
    Assignee: NIKON CORPORATION
    Inventors: Nobuhiko Maiya, Masafumi Yamashita, Shoko Yamasaki, Yosuke Otsubo, Shunsuke Takei
  • Patent number: 10746647
    Abstract: An analysis device includes an acquisition unit configured to acquire an image of a cell and an identification unit configured to identify elements that are identifiable on the basis of the image of cell acquired by the acquisition unit. Characteristic quantities of the elements identified by the identification unit are calculated, a correlation between the characteristic quantities is calculated on the basis of the calculated characteristic quantities of the elements, and a correlation between the elements is calculated on the basis of the calculated correlation between the characteristic quantities.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 18, 2020
    Assignees: THE UNIVERSITY OF TOKYO, NIKON CORPORATION
    Inventors: Masayuki Murata, Fumi Kano, Yoshiyuki Noguchi, Nobuhiko Maiya, Chisako Iwamoto, Shoko Yamasaki, Masafumi Yamashita
  • Publication number: 20200065556
    Abstract: An analysis device includes: a cell image acquisition unit that acquires a plurality of cell images in which a stimulated cell has been captured; a feature value calculation unit that calculates a feature value for each of first and second constituent elements constituting the cell, from the cell images acquired by the cell image acquisition unit; a correlation calculation unit that calculates correlations between first feature values and between second feature values in the first and second constituent elements calculated by the feature value calculation unit; a correlation extraction unit that extracts the correlation between the first feature values by selecting the first feature values with respect to the correlations between the feature values in the first and second constituent elements calculated by the correlation calculation unit; and a display unit that displays the correlation between the first feature values extracted by the correlation extraction unit.
    Type: Application
    Filed: November 10, 2016
    Publication date: February 27, 2020
    Applicants: THE UNIVERSITY OF TOKYO, NIKON CORPORATION
    Inventors: Masayuki MURATA, Fumi KANO, Yoshiyuki NOGUCHI, Hirotada WATANABE, Nobuhiko MAIYA, Shinichi FURUTA, Takuro SAIGO, Mamiko MASUTANI, Masafumi YAMASHITA, Shoko YAMASAKI
  • Publication number: 20200043159
    Abstract: An analysis device includes a living cell feature value extraction unit configured to extract a feature value of a living cell from a captured image of the living cell, a fixed cell feature value extraction unit configured to extract a feature value of a fixed cell from a captured image of a cell that is the fixed cell of the living cell, and a computing unit configured to associate a feature value of the living cell extracted by the living cell feature value extraction unit with a feature value of the fixed cell extracted by the fixed cell feature value extraction unit.
    Type: Application
    Filed: October 3, 2016
    Publication date: February 6, 2020
    Applicant: NIKON CORPORATION
    Inventors: Hirotada WATANABE, Nobuhiko MAIYA, Shunsuke TAKEI, Takuro SAIGO, Mamiko MASUTANI, Shinichi FURUTA, Masafumi YAMASHITA, Shoko YAMASAKI, Yosuke OTSUBO
  • Publication number: 20180349675
    Abstract: An image processing apparatus includes a cell image acquisition unit configured to acquire a cell image captured with cells, a characteristic amount calculation unit configured to calculate a plurality of types of characteristic amounts on the cell image acquired by the cell image acquisition unit, and a correlation extraction unit configured to extract specific correlations from among a plurality of correlations among the characteristic amounts calculated by the characteristic amount calculation unit, based on likelihood of the characteristic amounts.
    Type: Application
    Filed: December 22, 2015
    Publication date: December 6, 2018
    Applicant: NIKON CORPORATION
    Inventors: Nobuhiko MAIYA, Masafumi YAMASHITA, Shoko YAMASAKI, Yosuke OTSUBO, Shunsuke TAKEI
  • Publication number: 20170350805
    Abstract: An analysis device includes an acquisition unit configured to acquire an image of a cell and an identification unit configured to identify elements that are identifiable on the basis of the image of cell acquired by the acquisition unit. Characteristic quantities of the elements identified by the identification unit are calculated, a correlation between the characteristic quantities is calculated on the basis of the calculated characteristic quantities of the elements, and a correlation between the elements is calculated on the basis of the calculated correlation between the characteristic quantities.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 7, 2017
    Applicants: THE UNIVERSITY OF TOKYO, NIKON CORPORATION
    Inventors: Masayuki MURATA, Fumi KANO, Yoshiyuki NOGUCHI, Nobuhiko MAIYA, Chisako IWAMOTO, Shoko YAMASAKI, Masafumi YAMASHITA
  • Publication number: 20160319236
    Abstract: A culture device containing a culture vessel for culturing a cell, in which the culture device includes a thermostatic vessel having a stacker containing a plurality of culture vessels for culturing a cell, and an observation portion arranged to be isolated from an atmosphere at inside of the thermostatic vessel and having an object lens, an object lens drive portion, and a camera portion to observe a cell at inside of the culture vessel installed at an observation position at inside of the thermostatic vessel.
    Type: Application
    Filed: May 23, 2016
    Publication date: November 3, 2016
    Applicant: NIKON CORPORATION
    Inventors: Yasujiro KIYOTA, Takayuki UOZUMI, Hirofumi SHIONO, Nobuhiko MAIYA
  • Publication number: 20160298070
    Abstract: A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a transferring unit transferring a culture vessel for culturing a cell, an inputting unit inputting a kind of the culture vessel, a speed setting unit setting a transfer speed of the culture vessel based on a kind of the culture vessel inputted to the inputting unit, and a controlling unit controlling a transfer speed of the transferring unit to be the transfer speed set by the speed setting unit.
    Type: Application
    Filed: April 12, 2016
    Publication date: October 13, 2016
    Applicant: NIKON CORPORATION
    Inventors: Takayuki UOZUMI, Yasujiro KIYOTA, Nobuhiko MAIYA, Hirofumi SHIONO
  • Patent number: 9376657
    Abstract: A culture device containing a culture vessel for culturing a cell, in which the culture device includes a thermostatic vessel having a stacker containing a plurality of culture vessels for culturing a cell, and an observation portion arranged to be isolated from an atmosphere at inside of the thermostatic vessel and having an object lens, an object lens drive portion, and a camera portion to observe a cell at inside of the culture vessel installed at an observation position at inside of the thermostatic vessel.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: June 28, 2016
    Assignee: NIKON CORPORATION
    Inventors: Yasujiro Kiyota, Takayuki Uozumi, Hirofumi Shiono, Nobuhiko Maiya
  • Patent number: 9340764
    Abstract: A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a transferring unit transferring a culture vessel for culturing a cell, an inputting unit inputting a kind of the culture vessel, a speed setting unit setting a transfer speed of the culture vessel based on a kind of the culture vessel inputted to the inputting unit, and a controlling unit controlling a transfer speed of the transferring unit to be the transfer speed set by the speed setting unit.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: May 17, 2016
    Assignee: NIKON CORPORATION
    Inventors: Takayuki Uozumi, Yasujiro Kiyota, Nobuhiko Maiya, Hirofumi Shiono
  • Patent number: 9047502
    Abstract: An automatic culture device 1 having an automatic quality determination system is equipped with an analysis program 12. The analysis program 12 extracts cell characteristics from a captured image of a cell by driving a characteristic quantity extraction program 13, which is an image processing program for extracting characteristics (characteristic quantities) of this cell. The quality of the cell is then determined from the extracted characteristic or a combination of a plurality of characteristics by driving an identification program 15 that determines the quality of a cell. This allows cell quality determination to be automated.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: June 2, 2015
    Assignee: NIKON CORPORATION
    Inventors: Nobuhiko Maiya, Yasujiro Kiyota, Takayuki Uozumi, Hirofumi Shiono
  • Patent number: 9019361
    Abstract: A microscope apparatus and control method. An image processing unit obtains an image on a plane observation cross-section inside a sample. A drive control unit controls a galvano-scanner and a z drive unit, and inclines the entire observation cross-section in a direction where the cross-section of an observation target that appears in the image becomes long. When an edge portion of the cross-section of the observation target is detected in the observation cross-section while gradually inclining the observation cross-section, the drive control unit uses an axis passing through the edge portion as the center to incline a part of the observation cross-section located on a side, where the cross-section of the observation target does not appear, from among the sides having this axis as a boundary, in a direction where the cross-section of the observation target appears, so as to form the observation cross-section having a profile which is folded.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: April 28, 2015
    Assignee: Nikon Corporation
    Inventor: Nobuhiko Maiya
  • Publication number: 20120200691
    Abstract: A microscope apparatus and control method. An image processing unit obtains an image on a plane observation cross-section inside a sample. A drive control unit controls a galvano-scanner and a z drive unit, and inclines the entire observation cross-section in a direction where the cross-section of an observation target that appears in the image becomes long. When an edge portion of the cross-section of the observation target is detected in the observation cross-section while gradually inclining the observation cross-section, the drive control unit uses an axis passing through the edge portion as the center to incline a part of the observation cross-section located on a side, where the cross-section of the observation target does not appear, from among the sides having this axis as a boundary, in a direction where the cross-section of the observation target appears, so as to form the observation cross-section having a profile which is folded.
    Type: Application
    Filed: March 8, 2012
    Publication date: August 9, 2012
    Applicant: NIKON CORPORATION
    Inventor: Nobuhiko MAIYA
  • Patent number: 8192983
    Abstract: An incubator including a temperature-controlled room adjusted to a predetermined environment condition for culturing a sample of an incubation container at inside of the temperature-controlled room, the incubator including a shifting mechanism for moving a position of the incubation container at inside of the temperature-controlled room by a motor, a temperature adjusting section for adjusting a temperature at inside of the temperature-controlled room, an operating information generating section for generating operating information with regard to a position of operating and a time period of operating the motor prior to operating the motor, an estimated variation outputting section for outputting an estimation variation of a temperature state by operating the motor based on the operating information, and a controlling section for controlling the temperature adjusting section to cancel a temperature change of an amount of the estimated variation in synchronism with operating the motor.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: June 5, 2012
    Assignee: Nikon Corporation
    Inventors: Yasujiro Kiyota, Takayuki Uozumi, Nobuhiko Maiya, Hirofumi Shiono
  • Patent number: 8150137
    Abstract: It is a proposition to reduce user's burden when performing tracking observation of a specimen. Therefore, an image processing apparatus includes a storage unit which takes in a plurality of slice images acquired from a specific area of a specimen by each of Z-stack shootings performed at different time point, associates the plurality of slice images each with a shooting time point and slice height z, and stores the plurality of slice images as one of slice image groups, a manual selecting unit which allows user to manually select a representing image (Ia, Ib, Ic, . . . ) from one of slice image groups, and an automatic selecting unit which automatically selects a representing image from another one of slice image groups based on a result of the manual selection.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: April 3, 2012
    Assignee: Nikon Corporation
    Inventor: Nobuhiko Maiya
  • Patent number: 8139106
    Abstract: Provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images, and a recording unit which records at least one of an image group including one or more of the images captured during a predetermined period among a period of a time-lapse capturing performed by the time-lapse imaging unit or an image group including one or more of the images picked at predetermined time intervals among the period of the time-lapse capturing performed by the time-lapse imaging unit. Thus, data generated in time-lapse photography are managed favorably in a microscope apparatus provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: March 20, 2012
    Assignee: Nikon Corporation
    Inventor: Nobuhiko Maiya
  • Patent number: 8022373
    Abstract: An observing apparatus includes: a photographic unit that takes a region where cells are present as an observation object region based upon a macro image captured at low magnification of an interior of a cell culture vessel, and photographs the cells in the observation object region; an illuminating unit that irradiates light upon the cells only during photography by the photographic unit; and an output unit that outputs a fluorescent image photographed by the photographic unit while irradiating light only during photography by the illuminating unit. A recognition section recognizes at least one observation object region, within the macro image, in which cells are present. A selection unit selects a tiling mode or a random mode. A controller points an objective lens at an observation object region in which the recognition unit has recognized that cells are present.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: September 20, 2011
    Assignee: Nikon Corporation
    Inventor: Nobuhiko Maiya
  • Publication number: 20100047902
    Abstract: A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a transferring unit transferring a culture vessel for culturing a cell, an inputting unit inputting a kind of the culture vessel, a speed setting unit setting a transfer speed of the culture vessel based on a kind of the culture vessel inputted to the inputting unit, and a controlling unit controlling a transfer speed of the transferring unit to be the transfer speed set by the speed setting unit.
    Type: Application
    Filed: June 27, 2006
    Publication date: February 25, 2010
    Applicant: NIKON CORPORATION
    Inventors: Takayuki Uozumi, Yasujiro Kiyota, Nobuhiko Maiya, Hirofumi Shiono
  • Publication number: 20090237502
    Abstract: Provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images, and a recording unit which records at least one of an image group including one or more of the images captured during a predetermined period among a period of a time-lapse capturing performed by the time-lapse imaging unit or an image group including one or more of the images picked at predetermined time intervals among the period of the time-lapse capturing performed by the time-lapse imaging unit. Thus, data generated in time-lapse photography are managed favorably in a microscope apparatus provided with a time-lapse imaging unit which repeatedly captures a specimen at predetermined time intervals and generates a plurality of images.
    Type: Application
    Filed: May 27, 2009
    Publication date: September 24, 2009
    Applicant: NIKON CORPORATION
    Inventor: Nobuhiko Maiya