Patents by Inventor Nobuhiko Muramoto

Nobuhiko Muramoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12048900
    Abstract: An inorganic structure body has a free-standing structure including a fibrous member and/or a shell. The fibrous member and/or the shell include a metal and/or an inorganic material and have a three-dimensionally continuous configuration. The free-standing structure may have a structure that is based on a nonwoven fabric or a porous membrane used as a substrate.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 30, 2024
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Shougo Higashi, Keisuke Shigetoh, Atsushi Beniya, Nobuhiko Muramoto, Kazutaka Nishikawa, Shin Tajima, Ryoji Asahi
  • Patent number: 11479780
    Abstract: Epigenomic states of genome DNA are altered at multiple sites to rapidly change traits by providing a fusion protein including a first region that defines a polypeptide capable of binding sequence-specifically to multiple sites on genome DNA and a second region that defines a polypeptide capable of regulating an epigenomic state.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: October 25, 2022
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Hidenori Tanaka, Akinori Ikeuchi, Risa Onoda, Hiroki Sugimoto, Nobuhiko Muramoto
  • Patent number: 11464182
    Abstract: A method of inducing genetic recombination, including: allowing a protein having DNA double-stranded cleavage activity to act in cells of a eukaryotic organism which is a polyploidy inherently possessed by a eukaryotic organism. In eukaryotic organisms, various genetic recombination generates new genome set composition. This is done to obtain a population of eukaryotic organisms that hold the modified genomic set.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 11, 2022
    Assignees: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Nobuhiko Muramoto, Hidenori Tanaka, Hiroki Sugimoto, Norihiro Mitsukawa, Akinori Ikeuchi, Risa Nakamura, Ritsuko Yogo, Satoshi Katahira, Chikara Ohto, Satoshi Kondo
  • Patent number: 11248232
    Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 15, 2022
    Assignees: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, THE UNIVERSITY OF TOKYO, MEIJI UNIVERSITY
    Inventors: Hidenori Tanaka, Nobuhiko Muramoto, Hiroki Sugimoto, Norihiro Mitsukawa, Chikara Ohto, Satoshi Kondo, Kunihiro Ohta, Takahiro Nakamura, Shuichi Osato
  • Patent number: 11091755
    Abstract: A method includes introducing a protein having double-stranded DNA cleavage activity itself into the eukaryote or a part of the eukaryote, and rearranging DNA of the eukaryote by the protein in the eukaryote or a part of cells of the eukaryote.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: August 17, 2021
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Hidenori Tanaka, Nobuhiko Muramoto, Hiroki Sugimoto, Tomoko Tanaka
  • Publication number: 20200270620
    Abstract: Epigenomic states of genome DNA are altered at multiple sites to rapidly change traits by providing a fusion protein including a first region that defines a polypeptide capable of binding sequence-specifically to multiple sites on genome DNA and a second region that defines a polypeptide capable of regulating an epigenomic state.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 27, 2020
    Applicant: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Hidenori TANAKA, Akinori IKEUCHI, Risa ONODA, Hiroki SUGIMOTO, Nobuhiko MURAMOTO
  • Patent number: 10745691
    Abstract: Provided is a genome shuffling technology suited to creating a useful next-generation plant body. Genome shuffling is performed using a polypeptide comprising a first polypeptide region for double-stranded DNA breakage activity and a second polypeptide region for intertissue migration activity.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 18, 2020
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Nobuhiko Muramoto, Tomoko Tanaka, Hidenori Tanaka, Ritsuko Yogo, Hiroki Sugimoto
  • Publication number: 20200254395
    Abstract: An inorganic structure body has a free-standing structure including a fibrous member and/or a shell. The fibrous member and/or the shell include a metal and/or an inorganic material and have a three-dimensionally continuous configuration. The free-standing structure may have a structure that is based on a nonwoven fabric or a porous membrane used as a substrate.
    Type: Application
    Filed: September 7, 2018
    Publication date: August 13, 2020
    Applicant: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Shougo HIGASHI, Keisuke SHIGETOH, Atsushi BENIYA, Nobuhiko MURAMOTO, Kazutaka NISHIKAWA, Shin TAJIMA, Ryoji ASAHI
  • Patent number: 10584348
    Abstract: This invention is intended to increase biomass production through suppression of expression of a gene functioning in relation to intracellular vesicular transport or inhibition of functions of a protein encoded by such gene. To this end, expression of a gene encoding the coatomer adapter zeta subunit is suppressed, the coatomer adapter zeta subunit is inhibited, expression of a gene encoding the clathrin adaptor small (sigma) subunit is suppressed, or the clathrin adaptor small (sigma) subunit is inhibited.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 10, 2020
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Hiroki Sugimoto, Nobuhiko Muramoto, Tomoko Tanaka, Norihiro Mitsukawa, Ritsuko Yogo
  • Patent number: 10287604
    Abstract: A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences comprising the amino acid sequences shown in SEQ ID NOS: 1-3 from the N-terminal side in such order is over-expressed.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: May 14, 2019
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Norihiro Mitsukawa, Nobuhiko Muramoto, Kenichi Ogawa, Hiroki Sugimoto, Tomoko Tanaka, Madoka Yonekura
  • Publication number: 20180371477
    Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 27, 2018
    Applicants: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, The University of Tokyo, MEIJI UNIVERSITY
    Inventors: Hidenori TANAKA, Nobuhiko MURAMOTO, Hiroki SUGIMOTO, Norihiro MITSUKAWA, Chikara OHTO, Satoshi KONDO, Kunihiro OHTA, Takahiro NAKAMURA, Shuichi OSATO
  • Publication number: 20180305708
    Abstract: Provided is a genome shuffling technology suited to creating a useful next-generation plant body. Genome shuffling is performed using a polypeptide comprising a first polypeptide region for double-stranded DNA breakage activity and a second polypeptide region for intertissue migration activity.
    Type: Application
    Filed: December 11, 2017
    Publication date: October 25, 2018
    Applicant: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Nobuhiko Muramoto, Tomoko Tanaka, Hidenori Tanaka, Ritsuko Yogo, Hiroki Sugimoto
  • Publication number: 20180184606
    Abstract: A method of inducing genetic recombination, including: allowing a protein having DNA double-stranded cleavage activity to act in cells of a eukaryotic organism which is a polyploidy inherently possessed by a eukaryotic organism. In eukaryotic organisms, various genetic recombination generates new genome set composition. This is done to obtain a population of eukaryotic organisms that hold the modified genomic set.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 5, 2018
    Applicants: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Nobuhiko MURAMOTO, Hidenori TANAKA, Hiroki SUGIMOTO, Norihiro MITSUKAWA, Akinori IKEUCHI, Risa NAKAMURA, Ritsuko YOGO, Satoshi KATAHIRA, Chikara OHTO, Satoshi KONDO
  • Publication number: 20180179513
    Abstract: A method includes introducing a protein having double-stranded DNA cleavage activity itself into the eukaryote or a part of the eukaryote, and rearranging DNA of the eukaryote by the protein in the eukaryote or a part of cells of the eukaryote.
    Type: Application
    Filed: December 26, 2017
    Publication date: June 28, 2018
    Applicant: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Hidenori TANAKA, Nobuhiko MURAMOTO, Hiroki SUGIMOTO, Tomoko TANAKA
  • Patent number: 10000764
    Abstract: A gene having novel functions is searched for, by which plant weight (that is, biomass level) can be increased and by which substance productivity can be increased or decreased. A chimeric protein is expressed in which a transcriptional factor comprising the amino acid sequence shown in SEQ ID NO: 2, 4, or 6 is fused to a functional peptide that converts an arbitrary transcriptional factor into a transcriptional repression factor.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: June 19, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Masaru Takagi, Kyoko Matsui, Tomotsugu Koyama, Nobutaka Mitsuda, Nobuhiko Muramoto, Norihiro Mitsukawa, Tomoko Tanaka
  • Patent number: 9970020
    Abstract: According to the present invention, a gene having a novel function that can cause an increase or decrease in seed protein content is searched for. A chimeric protein obtained by fusing a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 1 to 76 and a functional peptide capable of converting an arbitrary transcription factor into a transcriptional repressor or a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 77 to 84 is expressed in a plant.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: May 15, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Madoka Yonekura, Chikara Ohto, Nobuhiko Muramoto, Norihiro Mitsukawa, Masaru Takagi, Kyoko Matsui
  • Patent number: 9902968
    Abstract: A method of increasing the biomass of a plant that includes planting a plant having plant cells carrying an exogenous gene that encodes a thermophilic restriction enzyme that promotes double-stranded DNA breakage, and growing the plant at least until after true leaf development, wherein the mean biomass of plants having the plant cells carrying the exogenous gene that are grown at least until after true leaf development is increased in comparison with the mean biomass of plants of the same species that do not carry the exogenous gene that are grown for the same amount of time.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 27, 2018
    Assignees: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, THE UNIVERSITY OF TOKYO
    Inventors: Nobuhiko Muramoto, Hiroki Sugimoto, Norihiro Mitsukawa, Kunihiro Ohta, Kazuto Kugou
  • Patent number: 9879274
    Abstract: A method for producing a plant includes growing a plant from plant cells in which a promoter and a coding sequence under the control of the promoter have been artificially introduced; and selecting the plant in which an amount of phloem tissue is increased 2.0 times or more in comparison with a wild type plant of the same species. The promoter is a promoter for a gene encoding a protein having at least 60% identity with the amino acid sequence of tracheary element differentiation inhibitory factor (TDIF) receptor (TDR) of Arabidopsis thaliana. The coding sequence encodes either (i) a protein having three common sequences composed of the amino acid sequences of SEQ ID NOS: 1 to 3 in this order starting from the N-terminal side, or (ii) a protein having 95% or more identity with the amino acid sequence of SEQ ID NO:5.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: January 30, 2018
    Assignee: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO
    Inventors: Tomoko Tanaka, Hiroki Sugimoto, Ritsuko Yogo, Nobuhiko Muramoto, Norihiro Mitsukawa, Kazufumi Tabata
  • Patent number: 9862963
    Abstract: A gene having novel functions is searched for, by which plant weight (that is, biomass level) can be increased and by which substance productivity can be increased or decreased. A chimeric protein is expressed in which a transcriptional factor comprising the amino acid sequence shown in SEQ ID NO: 2, 4, or 6 is fused to a functional peptide that converts an arbitrary transcriptional factor into a transcriptional repression factor.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: January 9, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Masaru Takagi, Kyoko Matsui, Tomotsugu Koyama, Nobutaka Mitsuda, Nobuhiko Muramoto, Norihiro Mitsukawa, Tomoko Tanaka
  • Patent number: 9856488
    Abstract: According to the present invention, a gene having a novel function that can cause an increase or decrease in seed protein content is searched for. A chimeric protein obtained by fusing a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 1 to 76 and a functional peptide capable of converting an arbitrary transcription factor into a transcriptional repressor or a transcription factor consisting of a protein comprising an amino acid sequence shown in any of the even-numbered SEQ ID NOS: 77 to 84 is expressed in a plant.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 2, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Madoka Yonekura, Chikara Ohto, Nobuhiko Muramoto, Norihiro Mitsukawa, Masaru Takagi, Kyoko Matsui