Patents by Inventor Nobuhiro KOYAMA

Nobuhiro KOYAMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound having therapeutic activity against mycobacterium avium complex infection, and method for producing same
    Patent number: 11407742
    Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: August 9, 2022
    Assignees: THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
    Inventors: Hiroshi Tomoda, Nobuhiro Koyama, Akihiko Kanamoto, Junko Hashimoto, Ikuko Kozone
  • COMPOSITION FOR INDUCING PILI FORMATION IN BACTERIUM OF GENUS BIFIDOBACTERIUM
    Publication number: 20220133665
    Abstract: The object is to provide a method for inducing pili formation in bacterium of genus Bifidobacterium and a method for promoting intestinal colonization of the bacterium. 3-Phenylpropionic acid and/or 3-(4-hydroxyphenyl)propionic acid are an active ingredient of a composition for inducing the pili formation in the bacterium of genus Bifidobacterium and a composition for promoting the intestinal colonization of the bacterium.
    Type: Application
    Filed: February 28, 2020
    Publication date: May 5, 2022
    Applicants: MORINAGA MILK INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, THE KITASATO INSTITUTE
    Inventors: Kanetada Shimizu, Ro Osawa, Keita Nishiyama, Nobuhiko Okada, Nobuhiro Koyama, Takao Mukai, Hiroshi Tomoda
  • NOVEL COMPOUND HAVING THERAPEUTIC ACTIVITY AGAINST MYCOBACTERIUM AVIUM COMPLEX INFECTION, AND METHOD FOR PRODUCING SAME
    Publication number: 20200407346
    Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 31, 2020
    Applicants: THE KITASATO INSTITUTE, OP BIO FACTORY CO., LTD.
    Inventors: Hiroshi TOMODA, Nobuhiro KOYAMA, Akihiko KANAMOTO, Junko HASHIMOTO, Ikuko KOZONE