Abstract: An embeddable and replenishable controlled drug release device which achieves drug delivery in which the drug release rate can be controlled is provided. The device can be replenished with a drug using a syringe and a needle when implanted in the body. The device has a capsule structure and includes (i) a controlled drug release part for controlled-release of a drug from the device, (ii) a drug storage part for keeping the drug and (iii) a drug introduction part for introducing the drug into the drug storage part. The controlled drug release part has a controlled-release face having a pore, and a hydrogel. The drug storage part is adjacent to the controlled drug release part, and releases the drug kept therein from the pore, and the drug is introduced into the drug storage part through the drug introduction part using a syringe and a needle.

Abstract: A capsule device, which can induce vascular bed formation and formation of a space for cell transplantation in subcutaneous tissue in which the device is implanted, is provided. A sustained drug release capsule device, which is to be subcutaneously implanted for subcutaneous sustained release of an angiogenesis-inducing factor as well as formation of a vascular bed as a basis for cell transplantation and a space for cell transplantation in cell therapy, the capsule being made of a material which is not soluble in a biological body and does not adhere to a biological body, and having micropores for sustained release of the angiogenesis-inducing factor.

Abstract: Provided is a novel method of manufacturing a cell-nanoscale thin film composite in which the cell-nanoscale thin film composite can be peeled from a substrate at a controlled timing. The method of manufacturing a cell-nanoscale thin film composite comprises culturing a cell in a cell culture base material in which a nanoscale thin film is provided on an electrode substrate with a self-assembled monolayer interposed therebetween, and reductively desorbing the self-assembled monolayer from the electrode substrate by applying an electric potential to the electrode substrate at a desired timing, so that the cell-nanoscale thin film composite is released.

Abstract: A drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. A sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: Disclosed is a drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. Specifically disclosed is a sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: A drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. A sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: The present invention provides a stretchable collagen material, particularly collagen derived from fishes, having excellent stretching property and mechanical strength, which can be widely used as a cell carrier and medical material, and to a method for manufacturing the same. By thermally treating a gel comprising collagen fiber cross-linked by using cross-linking agent, the collagen enhanced in both stretching property and mechanical strength can be produced. The stretchable collagen material is extremely useful as a cell carrier material and medical material.

Abstract: Disclosed is a drug delivery system for delivering a drug at a sustained constant rate for a long period, which can be transplanted into an affected part safely and in a simple manner and can deliver a drug to the affected part for a long period. Specifically disclosed is a sustained drug delivery system in which an implant is implanted into a body, wherein the implant is a PEG capsule comprising a box-shaped PEG and a porous PEG sheet.

Abstract: The present invention relates to a process of producing a collagen gel comprising collagen fibers cross-linked with each other by a cross-linking agent on the way of fibrosis of collagen, and a collagen gel comprising the cross-linked collagen fibers obtained by the process. The collagen gel comprising cross-linked collagen fibers of the present invention has high strength and thermal stability and can be widely used as cell carriers and medical materials.

Abstract: The present invention provides a stretchable collagen material, particularly collagen derived from fishes, having excellent stretching property and mechanical strength, which can be widely used as a cell carrier and medical material, and to a method for manufacturing the same. By thermally treating a gel comprising collagen fiber cross-linked by using cross-linking agent, the collagen enhanced in both stretching property and mechanical strength can be produced. The stretchable collagen material is extremely useful as a cell carrier material and medical material.

Abstract: The present invention provides a stretchable collagen material, particularly collagen derived from fishes, having excellent stretching property and mechanical strength, which can be widely used as a cell carrier and medical material, and to a method for manufacturing the same. By thermally treating a gel comprising collagen fiber cross-linked by using cross-linking agent, the collagen enhanced in both stretching property and mechanical strength can be produced. The stretchable collagen material is extremely useful as a cell carrier material and medical material.

Abstract: The present invention relates to a process of producing a collagen gel comprising collagen fibers cross-linked with each other by a cross-linking agent on the way of fibrosis of collagen, and a collagen gel comprising the cross-linked collagen fibers obtained by the process. The collagen gel comprising cross-linked collagen fibers of the present invention has high strength and thermal stability and can be widely used as cell carriers and medical materials.