Abstract: The compound of the formula ##STR1## is disclosed to have a less rapid decrease in blood pressure in its use as an antihypertensive.

Abstract: An optical isomer having an optical rotation degree of (+) from among (.+-.)-.alpha.-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dica rboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the hydrochloride of which has melting points ranging from 196.degree. to 202.degree. C.; or a salt thereof is described as being suitable for use in a pharmaceutical composition having hypotensive activity.

Abstract: Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different groups and each represents a lower alkyl group, one of R.sub.3 and R.sub.4 represents a lower alkyl group and the other represents a group of the general formula: ##STR2## wherein R.sub.5 represents an aralkyl group or an acyl group and n represents 0 or an integer of 1-3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.

Abstract: The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R.sub.1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.

Abstract: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R.sub.1 is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); (A).sub.m and R.sub.2 are usually used substituents; and Y is a monovalent group or a divalent group and is one of the following three groups: ##STR2## wherein when p is 0, B is --N.dbd.N--, ##STR3## and when p is 1, B is ##STR4## wherein (R.sub.3).sub.n is a usually used substituent, has hypotensive activity.

Abstract: A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); m and n are 0 or 1, and are different from each other (i.e., both m and n are not 0 or 1); and (D).sub.m', R.sup.1 and (R.sup.2)n' are usually used as substituents, has a hypotensive activity.

Abstract: Novel cephalosporin analogs and intermediates therefor are useful as antibiotics. Methods for producing the compounds are provided.

Abstract: A 2-azetidinone of formula (I): ##STR1## wherein R.sub.1 represents an aralkoxy, acyloxy, sulphonyloxy or amino group any of which may be substituted, or hydrogen, hydroxy, alkoxy or azido;R.sub.2 represents an alkyl or aralkyl group either of which may be substituted, or hydrogen;R.sub.3 represents an alkyl, aryl, aralkyl, alkenyl, aralkenyl, alkynyl, aralkynyl, acyl or heterocyclic group any of groups may be substituted;andR.sub.4 represents an alkyl, alkenyl, aryl or aralkyl group any of which may be substituted;or formula (I'): ##STR2## wherein R.sub.1 ' is the same as R.sub.1 above;R.sub.2 ' represents an alkyl, aralkyl or trialkylsilyl group any of which may be substituted, or hydrogen;R.sub.3 ' is the same as R.sub.3 above;andR.sub.4 ' represents an alkyl, aralkyl or trialkylsilyl group any of which may be substituted, or hydrogen; provided that when R.sub.1 ' represents azido or optionally substituted amino, R.sub.2 ' represents hydrogen or CH.sub.2 CCl.sub.3 and R.sub.4 ' represents ##STR3## R.sub.

Abstract: Novel cephalosporin analogs are disclosed which are useful as intermediates in the production of other compounds having antibacterial activity. Methods for producing the compounds are also disclosed.

Abstract: Novel compounds are disclosed which are useful as agents capable, when applied to citrus tree, of modifying the metabolism and organic acid content of the citrus fruit.

Abstract: This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.

Abstract: Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds.

Abstract: Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds.

Abstract: Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds.