Patents by Inventor Nobuhiro Ohi

Nobuhiro Ohi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzene derivatives, compositions and methods for treating ischemic diseases
    Patent number: 5998452
    Abstract: The present invention is directed to a compound represented by formula (I): wherein, for example, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each represents a hydrogen atom; R.sub.6 and R.sub.7 each represent a substituted or unsubstituted lower alkyl group; A represents a group represented by formula (II): ##STR1## wherein R.sub.5 represents, for example, a hydrogen atom; and n represents an integer of 2 to 6, or a stereoisomer or optical isomer thereof and a pharmaceutically acceptable salt thereof and compositions and methods for treating ischemic diseases. The compounds represented by formula (I) have an inhibitory action on calcium overload in addition to a vasorelaxing activity (calcium antagonism) and an inhibitory action on lipid peroxidation and are useful as a preventive or treating agent for ischemic diseases and hypertension.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: December 7, 1999
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Ohi, Tatsuya Kato, Tomokazu Ozaki, Kazuhiko Tamura, Yoshiyuki Suzuki, Michitaka Akima
  • Methotrexate derivative
    Patent number: 5728692
    Abstract: A compound represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms and a salt thereof, and an antirheumatic agent containing, as an active ingredient, at least one of these compounds.
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: March 17, 1998
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Ohi, Hiroshi Suzuki
  • Methotrexate derivative
    Patent number: 5354753
    Abstract: Disclosed is a compound represented by the formula: ##STR1## wherein R.sup.1 : CH.sub.2, CH.sub.2 CH.sub.2, CH.sub.2 O, CH.sub.2 S, CH.sub.2 SO; R.sup.2 : hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or a benzyl group; n: an integer of 1 to 4; R.sup.3 : COOR.sup.4, NHCOR.sup.5, CONR.sup.6 R.sup.7, PO.sub.3 H.sub.2, SO.sub.3 H.The compound shows potent antirheumatic function, psoriasis curing function and carcinostatic function and has low toxicity whereby it is available as a medicine.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: October 11, 1994
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Ohi, Hiroharu Matsuoka, Katushito Miyamoto, Hiroshi Suzuki, Nobuaki Kato, Keiichiro Tsuji, Yasuhisa Takeda, Masahiko Mihara, Hiromichi Nishina, Shin Shimaoka, Kenichi Akamatsu
  • Pyridine derivatives and their use as anti-allergic agents
    Patent number: 4691018
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group which may be substituted with hydroxy, lower alkyl or di-lower alkylamino; R.sub.2 is a hydrogen atom, an amino group or a lower alkylamino group; and R.sub.3 is a lower alkyl group, and a non-toxic salt thereof, and a process for preparing the same are disclosed.The compound and the salts thereof exhibit anti-allergic effects by the two different mechanisms and are expected to be useful as drugs for treating allergic diseases such as asthma, pollen allergy, atopic dermatitis and the like.
    Type: Grant
    Filed: May 6, 1986
    Date of Patent: September 1, 1987
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Mori, Nobuhiro Ohi, Yoshiyuki Ohsugi, Yasuhiro Yamashita