Patents by Inventor Nobuhiro Yagi
Nobuhiro Yagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11298326Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: GrantFiled: March 24, 2016Date of Patent: April 12, 2022Assignee: KYOWA KIRIN CO., LTD.Inventors: Kentaro Hatanaka, Nobuhiro Yagi, Takeshi Kuboyama, Kaori Yagi, Shintaro Hosoe
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Publication number: 20180353434Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: ApplicationFiled: March 24, 2016Publication date: December 13, 2018Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Kentaro HATANAKA, Nobuhiro YAGI, Takeshi KUBOYAMA, Kaori YAGI, Shintaro HOSOE
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Patent number: 9937127Abstract: An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.Type: GrantFiled: January 27, 2006Date of Patent: April 10, 2018Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Nobuhiro Yagi, Hiroko Sugishita, Masashi Nakakura, Hiroko Kusano
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Publication number: 20170349532Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: ApplicationFiled: August 18, 2017Publication date: December 7, 2017Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI, Nobuhiro YAGI
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Publication number: 20150247148Abstract: An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X?) complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X? being ribose substituted by a modifying group at 2? position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.Type: ApplicationFiled: May 18, 2015Publication date: September 3, 2015Inventors: Nobuhiro YAGI, Junichi Enokizono
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Patent number: 9061042Abstract: An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X?) complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X? being ribose substituted by a modifying group at 2? position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.Type: GrantFiled: January 31, 2011Date of Patent: June 23, 2015Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Nobuhiro Yagi, Junichi Enokizono
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Publication number: 20130280305Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: ApplicationFiled: November 2, 2012Publication date: October 24, 2013Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI, Nobuhiro YAGI
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Publication number: 20120301539Abstract: An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component (s) can be in the dispersed state in the liquid, and the like.Type: ApplicationFiled: August 2, 2012Publication date: November 29, 2012Inventors: Nobuhiro Yagi, Takuya Tokuda, Masashi Nakakura, Yasuki Kato
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Publication number: 20120203023Abstract: A novel process for the preparation of a phenylalanine derivative of formula (I):Type: ApplicationFiled: October 19, 2010Publication date: August 9, 2012Inventors: Joseph Paul Adams, Toru Kuroda, Hiroaki Matsumae, John Bryce Strachan, Nobuhiro Yagi
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Publication number: 20110182980Abstract: An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X?) complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X? being ribose substituted by a modifying group at 2? position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.Type: ApplicationFiled: January 31, 2011Publication date: July 28, 2011Inventors: Nobuhiro Yagi, Junichi Enokizono
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Patent number: 7970941Abstract: Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response.Type: GrantFiled: March 9, 2006Date of Patent: June 28, 2011Assignee: Digital Electronics CorporationInventors: Kentaro Kegoya, Minoru Yoshida, Shunu Tanigawa, Satoshi Kato, Nobuhiro Yagi, Masao Saito, Masaaki Yamada
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Patent number: 7953892Abstract: Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response.Type: GrantFiled: March 9, 2006Date of Patent: May 31, 2011Assignee: Digital Electronics CorporationInventors: Kentaro Kegoya, Minoru Yoshida, Shunu Tanigawa, Satoshi Kato, Nobuhiro Yagi, Masao Saito, Masaaki Yamada
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Patent number: 7937496Abstract: Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response.Type: GrantFiled: March 9, 2006Date of Patent: May 3, 2011Assignee: Digital Electronics CorporationInventors: Kentaro Kegoya, Minoru Yoshida, Shunu Tanigawa, Satoshi Kato, Nobuhiro Yagi, Masao Saito, Masaaki Yamada
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Publication number: 20090175930Abstract: There is provided a composition comprising an RNA-encapsulated liposome, the RNA comprising a sequence being of 15 to 30 contiguous nucleotides of mRNA of a target gene associated with a disease in an eyeball, and a sequence complementary to the sequence, wherein the liposome is capable of reaching an eyeball, and the like. The liposome in which an RNA is encapsulated is, for example, a liposome composing a complex particle comprising a lead particle and the RNA as constituent components, the lead particle comprising a cationic lipid, and a bilayer lipid membrane for coating the complex particle. The bilayer lipid membrane is a bilayer lipid membrane comprising a neutral lipid, and a lipid derivative, a fatty acid derivative or an aliphatic hydrocarbon derivative of a water-soluble substance as constituent components.Type: ApplicationFiled: January 10, 2007Publication date: July 9, 2009Inventors: Nobuhiro Yagi, Masahiro Yamauchi, Noboru Aoki, Yasuhiro Tamaki, Hidenori Takahashi, Aya Iriyama, Ryozo Nagai, Ichiro Manabe
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Publication number: 20090023918Abstract: The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N? or —CH?; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.Type: ApplicationFiled: September 5, 2008Publication date: January 22, 2009Inventors: Masahiko SEKI, Shin-ichi YOSHIDA, Nobuhiro YAGI, Masanori HATSUDA, Mayumi KIMURA, Kazuhiko KONDO
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Publication number: 20090011003Abstract: The present invention has its object to provide a composition for suppressing the expression of a target gene and the like, and provides a composition, comprising an RNA-encapsulated liposome which comprises complex particles comprising as constituent components a lead particle and an RNA comprising a sequence consisting of 15 to 30 contiguous nucleotides of a target gene mRNA and a sequence complementary to the sequence, and a lipid membrane for coating the complex particles, wherein constituent components of the lipid membrane can be solved in a polar organic solvent, and wherein the polar organic solvent can be contained in a liquid at such a concentration that the constituent components of the lipid membrane are dispersible and the complex particles are dispersible, and the like.Type: ApplicationFiled: October 24, 2005Publication date: January 8, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Masahiro Yamauchi, Tsuneaki Tottori, Atsushi Ishihara, Nobuhiro Yagi, Yasuki Kato
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Patent number: 7467231Abstract: Screen data is generated by a screen generating processor (74) of a control host computer (7) and transmitted to a programmable display apparatus (5). In accordance with the screen data, the programmable display apparatus (5) inquires a PLC (3) or the like about a state of a device (21), so as to update the display or transmit a control instruction depending on an input result. On the other hand, a control host computer (7) has a public server section (77) to transmit to a client apparatus (9) via the Internet an applet, which is generated by a compiler (76) compiling the screen data. The client apparatus (9) executes the applet to transmit to the public server section (77) an or the control instruction inquiry similar to those the programmable display apparatus (5) makes. In this way, the display is updated in accordance with a response.Type: GrantFiled: March 15, 2001Date of Patent: December 16, 2008Assignee: Digital Electronics CorporationInventors: Kentaro Kegoya, Minoru Yoshida, Shunu Tanigawa, Satoshi Kato, Nobuhiro Yagi, Masao Saito, Masaaki Yamada
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Patent number: 7439368Abstract: The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N? or —CH?; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3 is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.Type: GrantFiled: June 29, 2004Date of Patent: October 21, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masahiko Seki, Shin-ichi Yoshida, Nobuhiro Yagi, Masanori Hatsuda, Mayumi Kimura, Kazuhiko Kondo
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Publication number: 20080226704Abstract: The present invention provides a method of producing coated fine particles in which core fine particles is coated with a coating layer, which comprises the steps of preparing a liquid (liquid A) containing a polar organic solvent in which core fine particles are dispersed and a component constituting a coating layer is dissolved; preparing a liquid (liquid B) which is miscible with the liquid A and does not contain a polar organic solvent or contains a polar organic solvent in a ratio lower than that in the liquid A; and letting the liquid A flow from at least one inlet of a device for producing coated fine particles equipped with an in-line mixing means having two or more inlets and one or more outlet(s) and letting the liquid B flow from at least one remaining inlet to mix the liquids thereby coating the core fine particles with the coating layer.Type: ApplicationFiled: March 23, 2005Publication date: September 18, 2008Inventors: Makoto Kigoshi, Nobuhiro Yagi, Yasuki Kato
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Publication number: 20080171090Abstract: An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.Type: ApplicationFiled: January 27, 2006Publication date: July 17, 2008Inventors: Nobuhiro Yagi, Takuya Tokuda, Masashi Nakakura, Yasuki Kato