Patents by Inventor Nobuko OHSHIMA

Nobuko OHSHIMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining resistance to influenza virus
    Patent number: 9903874
    Abstract: Provided is a method of providing an effective means as a countermeasure for handling a pandemic of an influenza virus. The resistance to a type A influenza virus is determined using, as an indicator, the presence or otherwise of antibodies using the VH1-69 gene in a biological sample originating from a subject.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: February 27, 2018
    Assignee: FUJITA HEALTH UNIVERSITY
    Inventors: Yoshikazu Kurosawa, Nobuko Ohshima
  • Influenza virus-neutralizing antibody and screening method therefor
    Patent number: 9605053
    Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 28, 2017
    Assignees: Fujita Health University, The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Yoshikazu Kurosawa, Yoshitaka Iba, Nobuko Ohshima, Yoshinobu Okuno
  • Influenza virus-neutralizing antibody and screening method therefor
    Patent number: 9534042
    Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: January 3, 2017
    Assignees: Fujita Health University, The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Yoshikazu Kurosawa, Yoshitaka Iba, Nobuko Ohshima, Yoshinobu Okuno
  • METHOD OF DETERMINING RESISTANCE TO INFLUENZA VIRUS
    Publication number: 20160202265
    Abstract: Provided is a method of providing an effective means as a countermeasure for handling a pandemic of an influenza virus. The resistance to a type A influenza virus is determined using, as an indicator, the presence or otherwise of antibodies using the VH1-69 gene in a biological sample originating from a subject.
    Type: Application
    Filed: August 18, 2014
    Publication date: July 14, 2016
    Inventors: Yoshikazu Kurosawa, Nobuko Ohshima
  • INFLUENZA VIRUS-NEUTRALIZING ANTIBODY AND SCREENING METHOD THEREFOR
    Publication number: 20160152692
    Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Inventors: Yoshikazu KUROSAWA, Yoshitaka IBA, Nobuko OHSHIMA, Yoshinobu OKUNO
  • NOVEL EPITOPE AND MECHANISM OF ANTIGEN-ANTIBODY INTERACTION IN AN INFLUENZA VIRUS
    Publication number: 20140086927
    Abstract: Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by low pH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HA1 and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.
    Type: Application
    Filed: September 24, 2013
    Publication date: March 27, 2014
    Applicants: Fujita Health University, The Research Foundation for Microbial Diseases of Osaka University, Osaka University
    Inventors: Yoshikazu Kurosawa, Yoshitaka Iba, Nobuko Ohshima, Shigeyuki Yokoyama, Mikako Shirouzu, Yoshifumi Fujii, Tomomi Sumida, Kazuyoshi Ikuta, Shota Nakamura, Norihito Kawashita, Mitsuhiro Nishimura, Akifumi Yamashita, Yoshinobu Okuno, Ritsuko Kubota-Koketsu, Masahiro Okubo
  • INFLUENZA VIRUS-NEUTRALIZING ANTIBODY AND SCREENING METHOD THEREFOR
    Publication number: 20120058124
    Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
    Type: Application
    Filed: August 4, 2011
    Publication date: March 8, 2012
    Applicants: The Research Foundation for Microbial Diseases of Osaka University, FUJITA HEALTH UNIVERSITY
    Inventors: Yoshikazu KUROSAWA, Yoshitaka IBA, Nobuko OHSHIMA, Yoshinobu OKUNO