Patents by Inventor Nobuo Arai
Nobuo Arai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11150253Abstract: Disclosed is a method for analyzing a blood specimen, including the steps of: coagulating a blood specimen in the presence of an activating agent for fibrinolytic system to acquire a coagulation waveform; and acquiring information about fibrinolytic capacity of the blood specimen based on the acquired coagulation waveform.Type: GrantFiled: April 27, 2017Date of Patent: October 19, 2021Assignees: SYSMEX CORPORATION, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITYInventors: Midori Shima, Keiji Nogami, Tomoko Matsumoto, Sho Shinohara, Nobuo Arai
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Publication number: 20210302444Abstract: Disclosed is a method for measuring a blood coagulation activity, comprising: acquiring a parameter related to differentiation of a coagulation waveform in a blood specimen collected from a patient administered with (1) a polypeptide containing a sequence represented by SEQ ID NO: 1, or (2) a polypeptide containing a polypeptide having 95% or more identity with the sequence represented by SEQ ID NO: 1 and having an activity as a blood coagulation factor VIII; and acquiring an activity value of a blood coagulation factor VIII in the blood specimen based on the acquired parameter.Type: ApplicationFiled: March 24, 2021Publication date: September 30, 2021Applicants: SYSMEX CORPORATION, KEIO UNIVERSITY, SOCIAL WELFARE ORGANIZATION SAISEIKAI IMPERIAL GIFT FOUNDATION, INC.Inventors: Sho SHINOHARA, Osamu KUMANO, Nobuo ARAI, Seiji MADOIWA, Yuta FUJIMORI
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Patent number: 10739360Abstract: Disclosed is an analyzing method, for analyzing a blood specimen, which includes: mixing a blood specimen and a thrombin-containing reagent to coagulate the blood specimen, and obtaining a coagulation waveform; obtaining a value of a parameter concerning differentiation of the coagulation waveform, based on the coagulation waveform; and obtaining information concerning an amount of antigen of fibrinogen based on the obtained value of the parameter.Type: GrantFiled: April 19, 2018Date of Patent: August 11, 2020Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SYSMEX CORPORATIONInventors: Atsuo Suzuki, Tadashi Matsushita, Sho Shinohara, Nobuo Arai
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Publication number: 20180306820Abstract: Disclosed is an analyzing method, for analyzing a blood specimen, which includes: mixing a blood specimen and a thrombin-containing reagent to coagulate the blood specimen, and obtaining a coagulation waveform; obtaining a value of a parameter concerning differentiation of the coagulation waveform, based on the coagulation waveform; and obtaining information concerning an amount of antigen of fibrinogen based on the obtained value of the parameter.Type: ApplicationFiled: April 19, 2018Publication date: October 25, 2018Inventors: Atsuo SUZUKI, Tadashi MATSUSHITA, Sho SHINOHARA, Nobuo ARAI
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Patent number: 9933443Abstract: Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.Type: GrantFiled: March 28, 2016Date of Patent: April 3, 2018Assignees: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SYSMEX CORPORATIONInventors: Osamu Kumano, Naohiko Matsuo, Nobuo Arai, Masahiro Ieko
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Publication number: 20180031539Abstract: Disclosed is a method for determining the severity of hemophilia, the method including the steps of: coagulating a blood specimen to acquire a coagulation waveform; acquiring an average change rate of a coagulation rate from the coagulation waveform; and determining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate.Type: ApplicationFiled: July 27, 2017Publication date: February 1, 2018Applicants: SYSMEX CORPORATION, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITYInventors: Midori SHIMA, Keiji NOGAMI, Tomoko MATSUMOTO, Yuka TABUCHI, Nobuo ARAI
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Publication number: 20170315142Abstract: Disclosed is a method for analyzing a blood specimen, including the steps of: coagulating a blood specimen in the presence of an activating agent for fibrinolytic system to acquire a coagulation waveform; and acquiring information about fibrinolytic capacity of the blood specimen based on the acquired coagulation waveform.Type: ApplicationFiled: April 27, 2017Publication date: November 2, 2017Applicants: SYSMEX CORPORATION, PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITYInventors: Midori SHIMA, Keiji NOGAMI, Tomoko MATSUMOTO, Sho SHINOHARA, Nobuo ARAI
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Publication number: 20160291042Abstract: Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.Type: ApplicationFiled: March 28, 2016Publication date: October 6, 2016Applicants: SCHOOL JURIDICAL PERSON HIGASHI-NIPPON-GAKUEN, SYSMEX CORPORATIONInventors: Osamu KUMANO, Naohiko MATSUO, Nobuo ARAI, Masahiro IEKO
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Patent number: 6917021Abstract: There is disclosed a heating apparatus with electrostatic attraction function 1, comprising at least a supporting base 2, an electrode for electrostatic attraction 4 and a heating layer 5 that are formed on the supporting base, and an insulating layer 6 that is formed on the electrode for electrostatic attraction and the heating layer, wherein the electrode for electrostatic attraction and/or the heating layer are/is composed of pyrolytic graphite containing boron and/or boron carbide of 0.001-30% by weight in terms of boron concentration, and the insulating layer has an electric resistivity of 106-1015 ?cm. There is provided a heating apparatus with electrostatic attraction function, which has a high thermal shock resistance, no problem of delamination, a proper resistance value, and a sufficient electrostatic attraction force even in a medium and high temperature range of 500-800° C.Type: GrantFiled: June 19, 2003Date of Patent: July 12, 2005Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Shoji Kano, Ryouji Iwai, Nobuo Arai
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Publication number: 20030234248Abstract: There is disclosed a heating apparatus with electrostatic attraction function 1, comprising at least a supporting base 2, an electrode for electrostatic attraction 4 and a heating layer 5 that are formed on the supporting base, and an insulating layer 6 that is formed on the electrode for electrostatic attraction and the heating layer, wherein the electrode for electrostatic attraction and/or the heating layer are/is composed of pyrolytic graphite containing boron and/or boron carbide of 0.001-30% by weight in terms of boron concentration, and the insulating layer has an electric resistivity of 106-1015 &OHgr;cm. There is provided a heating apparatus with electrostatic attraction function, which has a high thermal shock resistance, no problem of delamination, a proper resistance value, and a sufficient electrostatic attraction force even in a medium and high temperature range of 500-800° C.Type: ApplicationFiled: June 19, 2003Publication date: December 25, 2003Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Shoji Kano, Ryouji Iwai, Nobuo Arai
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Patent number: 6176256Abstract: A gas pressure-reducing valve in which a valve member to be seated on a valve seat having a valve hole opened at its central portion and leading to a pressure-reducing chamber between a body and a diaphragm is fixed on a valve stem connected to the central portion of the diaphragm and arranged coaxially with the valve axis. A bottomed mounting bore which is aligned with the valve axis and opened toward the pressure-reducing chamber is formed in the body. A cylindrical valve seat member forming a valve chamber between itself and the closed end of the mounting bore for accommodating the valve member and inserted into the mounting bore is fixed on the body. A valve seat facing the valve chamber is formed on the inner surface of the end portion of the valve seat member on the side of the pressure-reducing chamber. This arrangement makes it possible to reduce the number of parts and to enhance the degree of freedom for the arrangement of the parts in the body.Type: GrantFiled: March 23, 1999Date of Patent: January 23, 2001Assignees: Keihin Corporation, Honda Giken Kogyo Kabushiki KaishaInventors: Yoji Nakajima, Hiroyuki Iwasaki, Kazuki Ishikawa, Yoshio Saito, Nobuo Arai, Hiroyuki Goto, Shuichi Togasawa
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Patent number: 6026789Abstract: A regulator for compressed natural gas is prevented from being frozen and from being heated to higher than a degree appropriate for prevention of the freezing.A hot-water passage 11 for circulating a portion of the engine cooling water is provided adjacent to a gas passage 24 equipped with a reducing valve 21 in the primary decompression section A of the regulator. A hot-water outlet member 10 is provided at the outlet aperture of the hot-water passage 11. A temperature sensitive valve 42 is mounted in the hot-water outlet member 10 and is set so that the hot-water passage 11 is closed with the valve body 48 when the temperature of the hot-water exceeds the degree appropriate for prevention of the freeze at the outlet aperture.Type: GrantFiled: June 8, 1998Date of Patent: February 22, 2000Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Nobuo Arai, Naoyuki Enjoji
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Patent number: 5665260Abstract: A ceramic electrostatic chuck with a built-in heater having electrodes of an electroconductive ceramic bonded to a surface of a supporting substrate of an electrically conducting ceramic. A heat generating layer of an electroconductive ceramic is bonded to the other surface of the supporting substrate and a covering layer of an electrically insulating ceramic is provided thereon. Each of the supporting substrate, electrode for the electrostatic chuck and heat generating layer has a surface roughness Rmax of 5 .mu.m or larger.Type: GrantFiled: December 27, 1994Date of Patent: September 9, 1997Assignees: Shin-Etsu Chemical Co., Ltd., Tokyo Electoron LimitedInventors: Nobuo Kawada, Shoji Kano, Koji Hagiwara, Nobuo Arai, Junichi Arami, Kenji Ishikawa
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Patent number: 5632250Abstract: Supply of fuel is stopped when fuel pressure sensed by a pressure sensor provided upstream of a regulator is at a predetermined value or less to avoid abnormal combustion caused by improper adjustment of air/fuel ratio. Even slight variation of the fuel pressure is sensed by monitoring the fuel pressure in an interval after closing a fuel shut-off valve once opened to re-opening of it. In addition, an abnormal state in the fuel system is detected by comparing an accumulated value of amount of injected fuel and an estimated value of fuel consumption in the tank. Furthermore, the peak current value of the fuel injection valve is controlled so that, when the engine at a low temperature is started, lift load of the injection valve is larger than sticking force of the injection valve, thereby preventing such situation where the injection valve is frozen so that it cannot supply fuel to the engine. In this case, the engine can be smoothly started by simultaneously controlling the valve open time.Type: GrantFiled: September 19, 1995Date of Patent: May 27, 1997Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Atsushi Kato, Yoshikazu Ohshima, Eisaku Gosho, Kazuhiro Ueda, Shigeo Hidai, Akira Murakami, Toshiyuki Nishida, Shigeru Aoki, Ryuichi Noseyama, Kenichiro Ishibashi, Katsunori Nakamura, Nobuo Arai
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Patent number: 5067038Abstract: A rotary magnetic head device utilizes a thin film magnetic head or heads having small mutual influence to external magnetic field in combination with a bulk magnetic head or heads to reduce crosstalk between recording head and reproducing head to thereby improve S/N ratio.Type: GrantFiled: July 5, 1990Date of Patent: November 19, 1991Assignee: Hitachi, Ltd.Inventors: Toshio Tsuchiya, Mitsuo Abe, Nobuo Arai, Masumi Hisatomi, Hideo Zama