Patents by Inventor Nobuo Ida
Nobuo Ida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9056095Abstract: An immunogenic composition includes as an effective ingredient an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment is a poly(hydroxy acid), or a particle composed of the antigen-adjuvant microparticle complex associated together, can induce a high immune response against the antigen even with a small amount of the antigen and a small number of doses, so that the immunogenic composition is useful as a vaccine effective for therapy and prophylaxis of infectious diseases, cancer and the like.Type: GrantFiled: February 26, 2010Date of Patent: June 16, 2015Assignee: Toray Industries, Inc.Inventors: Reiji Nishio, Nobuo Ida
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Patent number: 8895503Abstract: A method for nasal administration of a pharmaceutical composition comprising a hydrophilic bioactive substance and any one of (a) to (c): (a) a peptide having the amino acid sequence shown in SEQ ID NO:1; (b) a peptide having the same amino acid sequence as shown in SEQ ID NO:1 except that one or several amino acids are deleted, substituted and/or added, the peptide having nasal mucosal permeability; (c) a peptide having an amino acid sequence represented by the reverse sequence of (a) or (b), the peptide having nasal mucosal permeability, with the proviso that a C-terminal amidated peptide is excluded. A hydrophilic bioactive substance having a low transmucosal absorption capability which has conventionally been able to be administered by only injection can be nasally administered. Such a pharmaceutical composition is useful for improvement of the pain and the inconvenience of patients caused by administration by injection.Type: GrantFiled: February 27, 2009Date of Patent: November 25, 2014Assignee: Toray Industries, Inc.Inventors: Mariko Morishita, Kozo Takayama, Reiji Nishio, Nobuo Ida
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Patent number: 8772449Abstract: A cell-penetrating peptide of (A) to (D) below gives cell membrane permeability and transmucosal absorbability to a physiologically active substance: (A) a peptide having the amino acid sequence of SEQ ID NO:1; (B) a peptide represented by SEQ ID NO:1 except that one or several basic amino acids are changed; (C) a peptide represented by SEQ ID NO:1 except that 1 to 5 amino acids are changed; (D) a peptide having: the reverse sequence of any of (A) to (C); an amino acid sequence which is the same as the reverse sequence of (A) except that one or several basic amino acids are changed; or an amino acid sequence which is the same as the reverse sequence of (A) except that 1 to 5 amino acids are changed.Type: GrantFiled: May 19, 2010Date of Patent: July 8, 2014Assignee: Toray Industries, Inc.Inventors: Mariko Morishita, Kozo Takayama, Reiji Nishio, Nobuo Ida
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Patent number: 8431161Abstract: A microparticle includes an agglomerate of a hydrophilic active substance containing particle, which particle includes an amphiphilic polymer composed of a hydrophobic segment of poly(hydroxy acid) and a hydrophilic segment of polysaccharides or polyethylene glycol, and a hydrophilic active substance. It is characterized by an efficient inclusion of the hydrophilic active substance, and a release of the hydrophilic active substance at an appropriate speed in the human body, and is hence very useful as a DDS pharmaceutical preparation.Type: GrantFiled: February 20, 2009Date of Patent: April 30, 2013Assignee: Toray Industries, Inc.Inventors: Yoshinori Kakizawa, Reiji Nishio, Junji Michizoe, Masakazu Koiwa, Nobuo Ida, Taisuke Hirano, Yoichiro Koshi
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Publication number: 20120065124Abstract: A cell-penetrating peptide of (A) to (D) below gives cell membrane permeability and transmucosal absorbability to a physiologically active substance: (A) a peptide having the amino acid sequence of SEQ ID NO:1; (B) a peptide represented by SEQ ID NO:1 except that one or several basic amino acids are changed; (C) a peptide represented by SEQ ID NO:1 except that 1 to 5 amino acids are changed; (D) a peptide having: the reverse sequence of any of (A) to (C); an amino acid sequence which is the same as the reverse sequence of (A) except that one or several basic amino acids are changed; or an amino acid sequence which is the same as the reverse sequence of (A) except that 1 to 5 amino acids are changed.Type: ApplicationFiled: May 19, 2010Publication date: March 15, 2012Applicant: TORAY INDUSTRIES, INC.Inventors: Mariko Morishita, Kozo Takayama, Reiji Nishio, Nobuo Ida
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Publication number: 20110300223Abstract: An immunogenic composition includes as an effective ingredient an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment is a poly(hydroxy acid), or a particle composed of the antigen-adjuvant microparticle complex associated together, can induce a high immune response against the antigen even with a small amount of the antigen and a small number of doses, so that the immunogenic composition is useful as a vaccine effective for therapy and prophylaxis of infectious diseases, cancer and the like.Type: ApplicationFiled: February 26, 2010Publication date: December 8, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Reiji Nishio, Nobuo Ida
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Publication number: 20110020280Abstract: By a pharmaceutical composition for nasal administration comprising a hydrophilic bioactive substance and any one of (a) to (c) below, with the proviso that a C-terminal amidated peptide is excluded, a hydrophilic bioactive substance having a low transmucosal absorption capability which has conventionally been able to be administered by only injection can be nasally administered. Such a pharmaceutical composition is useful for improvement of the pain and the inconvenience of patients caused by administration by injection. (a) A peptide having the amino acid sequence shown in SEQ ID NO:1. (b) A peptide having the same amino acid sequence as shown in SEQ ID NO:1 except that one or several amino acids are deleted, substituted and/or added, the peptide having nasal mucosal permeability. (c) A peptide having an amino acid sequence represented by the reverse sequence of (a) or (b), the peptide having nasal mucosal permeability.Type: ApplicationFiled: February 27, 2009Publication date: January 27, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Mariko Morishita, Kozo Takayama, Reiji Nishio, Nobuo Ida
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Publication number: 20110003007Abstract: A microparticle includes an agglomerate of a hydrophilic active substance containing particle, which particle includes an amphiphilic polymer composed of a hydrophobic segment of poly (hydroxy acid) and a hydrophilic segment of polysaccharides or polyethylene glycol, and a hydrophilic active substance. It is characterized by an efficient inclusion of the hydrophilic active substance, and a release of the hydrophilic active substance at an appropriate speed in the human body, and is hence very useful as a DDS pharmaceutical preparation.Type: ApplicationFiled: February 20, 2009Publication date: January 6, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Yoshinori Kakizawa, Reiji Nishio, Junji Michizoe, Masakazu Koiwa, Nobuo Ida, Taisuke Hirano, Yoichiro Koshi
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Publication number: 20100184695Abstract: A peptide consisting of an amino acid sequence represented by any one of SEQ ID Nos. 1 to 76 of the present invention, a peptide consisting of an amino acid sequence in which one or several amino acids are substituted, deleted, inserted or added in these amino acid sequences, and having an ability to bind to, or to be taken into an activated vascular endothelial cell, or a peptide containing the above peptide as a partial sequence, and having an ability to bind to, or to be taken into an activated vascular endothelial cell is a novel peptide ligand specifically binding to a neovascular endothelial cell, and such a ligand can be effectively used for treating and diagnosing a disease accompanying vascularization such as a solid tumor.Type: ApplicationFiled: December 21, 2007Publication date: July 22, 2010Inventors: Yuichi Koyamatsu, Mark Micallef, Nobuo Ida, Masakazu Koiwa, Yoshinori Kakizawa
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Patent number: 7408045Abstract: An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.Type: GrantFiled: July 21, 2006Date of Patent: August 5, 2008Assignee: Toray Industries, Inc.Inventors: Ikuro Maruyama, Nobuo Ida, Sanae Masuko
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Publication number: 20080145432Abstract: A fine particle comprising an amphiphilic polymer, further comprising an inner nucleus of hydrophilic segment of amphiphilic polymer, and a hydrophobic outer layer of hydrophobic segment of amphiphilic polymer, and having a surface modifier bonded to the hydrophobic outer layer. A fine particle of the invention effectively enclose protein, peptide drug, nucleic acid medicine of hydrophilic property and large molecular weight in the inner nucleus of hydrophilic segment of amphiphilic polymer, and are preferable for stabilizing in the body and promoting absorption.Type: ApplicationFiled: March 6, 2006Publication date: June 19, 2008Inventors: Yoshinori Kakizawa, Takao Aoki, Nobuo Ida, Reiji Nishio
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Publication number: 20080019918Abstract: A pharmaceutical preparation has a ligand structure specifically recognizing a target site and an amphiphilic compound having a hydrophobic or amphiphilic group. The pharmaceutical preparation employs an amphiphilic compound of specific structure obtained by introducing a chained hydrophilic group with an appropriate flexibility, and thus becomes a fine particle suited for drug targeting. The pharmaceutical preparation is expected to give a prolonged pharmacological effect. A particulate preparation exhibiting a remarkable site targeting property can be formed. Further, according to the selection of matrix forming material, the drug releasing property can be controlled.Type: ApplicationFiled: September 7, 2005Publication date: January 24, 2008Inventors: Takao Aoki, Shinichi Yamane, Shinichi Kawanami, Yuichi Koyamatsu, Yoshifumi Watanabe, Itaru Hamachi, Ryo Suzuki, Masakazu Koiwa, Nobuo Ida
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Patent number: 7206957Abstract: A user circuit unit is configured by a gate array, a PLL circuit is configured in a microprocessor macro unit, a clock frequency output from the PLL circuit in the microprocessor macro unit is directly distributed to a user circuit unit (CLK 3), and the clock frequency distributed to the user circuit unit is distributed to the microprocessor macro unit through a frequency divider configured by the user circuit unit.Type: GrantFiled: April 22, 2002Date of Patent: April 17, 2007Assignee: NEC Electronics CorporationInventors: Yoshitaka Aoki, Nobuo Ida, Rumi Hikiba, Yoshinobu Nakajima
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Publication number: 20060258853Abstract: An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.Type: ApplicationFiled: July 21, 2006Publication date: November 16, 2006Inventors: Ikuro Maruyama, Nobuo Ida, Sanae Masuko
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Publication number: 20020180502Abstract: A user circuit unit is configured by a gate array, a PLT circuit is configured in a microprocessor macro unit, a clock frequency output from the PLL circuit in the microprocessor macro unit is directly distributed to auser circuit unit (CLK 3), and the clock frequency distributed to the user circuit unit is distributed to the microprocessor macro unit through a frequency divider configured by the user circuit unit.Type: ApplicationFiled: April 22, 2002Publication date: December 5, 2002Inventors: Yoshitaka Aoki, Nobuo Ida, Rumi Hikiba, Yoshinobu Nakajima
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Publication number: 20020164644Abstract: An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention comprises a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.Type: ApplicationFiled: March 28, 2002Publication date: November 7, 2002Inventors: Ikuro Maruyama, Nobuo Ida, Sanae Masuko
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Patent number: 6083501Abstract: A drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation, as well as a model animal of fibrinoid formation or thrombus formation in the lung is disclosed. The drug for preventing and treating diseases caused by fibrinoid formation or thrombus formation in the lung according to the present invention comprises an inhibitor of interleukin 6 as an effective ingredient. The model animal of the diseases caused by fibrinoid formation or thrombus formation in the lung is a rat in which fibrinoid formation or thrombus formation actually occurs by induction with interleukin 6.Type: GrantFiled: March 14, 1996Date of Patent: July 4, 2000Assignee: Toray Industries, Inc.Inventors: Masayuki Miyata, Reiji Kasukawa, Masanobu Naruto, Nobutaka Ida, Yu-ichiro Sato, Katsuaki Kojima, Nobuo Ida
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Patent number: 4770774Abstract: A column comprising an insoluble carrier and an anti-.beta..sub.2 -microglobulin antibody immobilized to the carrier can specifically adsorb and remove .beta..sub.2 -microglobulin in the blood. This column is useful for the prevention and treatment of diseases such as carpal tunnel syndrome observed in patients undergoing blood dialysis.Type: GrantFiled: May 14, 1987Date of Patent: September 13, 1988Assignee: Toray Industries, Inc.Inventors: Nobuo Ida, Hiroshi Kataoka, Tetsunosuke Kunitomo