Patents by Inventor Nobuo Ikota

Nobuo Ikota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiation protection drug containing tocopherol or tocotrienol compound ester derivative as active ingredient
    Patent number: 8299277
    Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: October 30, 2012
    Assignees: National Institute of Radiological Sciences, Fukuoka University
    Inventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
  • RADIATION PROTECTION DRUG CONTAINING TOCOPHEROL OR TOCOTRIENOL COMPOUND ESTER DERIVATIVE AS ACTIVE INGREDIENT
    Publication number: 20100048512
    Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.
    Type: Application
    Filed: November 14, 2007
    Publication date: February 25, 2010
    Applicants: National Institute of Radiological Sciences, Fukuoka University
    Inventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
  • Reagents for the determination of cerebral regional acetylcholinesterase activity
    Patent number: 6509003
    Abstract: The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); wherein R1 represents optionally fluorinated lower alkyl; R2 represents lower alkyl; and R3 represents alkenyl substituted at the 1-position with hydroxy, lower alkoxy, lower alkoxyalkyloxy, lower alkoxyalkyloxyalkyloxy, or lower alkanoyloxy and substituted at the end with radioactive iodine, or alkenyloxymethyl substituted at the end with a radioactive iodine reagent containing the same for assaying central local AchE activity; a method for assaying the central local AchE activity; and labeled precursors of the above compounds. After easily passing through the blood-brain barrier, these compounds are hydrolyzed specifically by AchE in the brain into alcohols, which are then captured by the brain. In contrast, alcohols formed outside the brain do not migrate into the brain. The compounds of the invention emit &ggr;-rays at an appropriate energy level.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: January 21, 2003
    Assignees: Daiichi Pure Chemicals Co., Ltd., Daiichi Radioisotope Laboratories, Ltd.
    Inventors: Toshiaki Irie, Kiyoshi Fukushi, Hiroki Namba, Masaomi Iyo, Nobuo Ikota, Shinichiro Nagatsuka, Takao Ueda, Masaru Nishiura, Keizo Takatoku, Isamu Yomoda
  • Reagents for the determination of cerebral regional acetylcholinesterase activity
    Publication number: 20020127180
    Abstract: The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); 1
    Type: Application
    Filed: January 19, 2001
    Publication date: September 12, 2002
    Applicant: DAIICHI PURE CHEMICALS CO., LTD
    Inventors: Toshiaki Irie, Kiyoshi Fukushi, Hiroki Namba, Masaomi Iyo, Nobuo Ikota, Shinichiro Nagatsuka, Takao Ueda, Masaru Nishiura, Keizo Takatoku, Isamu Yomoda
  • Reagents for assaying central local acetylcholinesterase activity
    Patent number: 6306882
    Abstract: The present invention relates to N-alkylpiperidine derivatives represented by general formula (1) or (2); wherein R1 represents optionally fluorinated lower alkyl; R2 represents lower alkyl; and R3 represents alkenyl substituted at the 1-position with hydroxy, lower alkoxy, lower alkoxyalkyloxy, lower alkoxyalkyloxyalkyloxy, or lower alkanoyloxy and substituted at the end with radioactive iodine, or alkenyloxymethyl substituted at the end with a radioactive iodine reagent containing the same for assaying central local AchE activity; a method for assaying the central local AchE activity; and labeled precursors of the above compounds. After easily passing through the blood-brain barrier, these compounds are hydrolyzed specifically by AchE in the brain into alcohols, which are then captured by the brain. In contrast, alcohols formed outside the brain do not migrate into the brain. The compounds of the invention emit &ggr;-rays at an appropriate energy level.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: October 23, 2001
    Assignees: Daiichi Pure Chemicals Co., Ltd., Daiichi Radioisotope Laboratories, Ltd.
    Inventors: Toshiaki Irie, Kiyoshi Fukushi, Hiroki Namba, Masaomi Iyo, Nobuo Ikota, Shinichiro Nagatsuka, Takao Ueda, Masaru Nishiura, Keizo Takatoku, Isamu Yomoda