Patents by Inventor Nobuo Kamada

Nobuo Kamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing antibodies
    Patent number: 8013208
    Abstract: This invention provides methods for producing antibodies, wherein the methods comprise the step of administering an immunogen comprising both a target antigen and a background antigen to transgenic animals, into which a gene coding for the background antigen has been introduced. Since immunotolerance to the background antigens have thus been induced in the transgenic animals, the animals efficiently produce antibodies to target antigens.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: September 6, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tatsuhiko Kodama, Kou-ichi Jishage, Nobuo Kamada, Yoshiki Yamada
  • Transgenic mice expressing baculovirus soluble GP64 and methods of using such mice to make antibodies
    Patent number: 7964767
    Abstract: Membrane proteins that are background antigens were solubilized, and transgenic animals were produced using genes encoding these soluble proteins. Antibodies against the background antigen membrane proteins comprised in the immunogens were not found in these transgenic animals, and even when genes encoding soluble proteins were used, immunotolerance against the full-length membrane proteins could be induced. Moreover, by expressing the background antigen membrane proteins as soluble proteins inside the bodies of transgenic animals, unfavorable phenotypes that appear when the full-length membrane proteins are expressed could be avoided, and such animals were made widely available as immunized animals.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: June 21, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tatsuhiko Kodama, Yoshiki Yamada, Nobuo Kamada, Kou-Ichi Jishage
  • Methods for Producing Antibodies
    Publication number: 20100218267
    Abstract: This invention provides methods for producing antibodies, wherein the methods comprise the step of administering an immunogen comprising both a target antigen and a background antigen to transgenic animals, into which a gene coding for the background antigen has been introduced. Since immunotolerance to the background antigens have thus been induced in the transgenic animals, the animals efficiently produce antibodies to target antigens.
    Type: Application
    Filed: May 7, 2010
    Publication date: August 26, 2010
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Tatsuhiko Kodama, Kou-ichi Jishage, Nobuo Kamada, Yoshiki Yamada
  • Methods for producing antibody
    Patent number: 7750204
    Abstract: This invention provides methods for producing antibodies, wherein the methods comprise the step of administering an immunogen comprising both a target antigen and a background antigen to transgenic animals, into which a gene coding for the background antigen has been introduced. Since immunotolerance to the background antigens have thus been induced in the transgenic animals, the animals efficiently produce antibodies to target antigens.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: July 6, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tatsuhiko Kodama, Kou-Ichi Jishage, Nobuo Kamada, Yoshiki Yamada
  • Nonhuman Animals for Antibody Production, and Methods and Systems for Producing Anitbodies Using Such Animals
    Publication number: 20080040820
    Abstract: Membrane proteins that are background antigens were solubilized, and transgenic animals were produced using genes encoding these soluble proteins. Antibodies against the background antigen membrane proteins comprised in the immunogens were not found in these transgenic animals, and even when genes encoding soluble proteins were used, immunotolerance against the full-length membrane proteins could be induced. Moreover, by expressing the background antigen membrane proteins as soluble proteins inside the bodies of transgenic animals, unfavorable phenotypes that appear when the full-length membrane proteins are expressed could be avoided, and such animals were made widely available as immunized animals.
    Type: Application
    Filed: March 31, 2005
    Publication date: February 14, 2008
    Inventors: Tatsuhiko Kodama, Yoshiki Yamada, Nobuo Kamada, Kou-Ichi Jishage
  • Method of constructing antibody
    Publication number: 20050222391
    Abstract: This invention provides methods for producing antibodies, wherein the methods comprise the step of administering an immunogen comprising both a target antigen and a background antigen to transgenic animals, into which a gene coding for the background antigen has been introduced. Since immunotolerance to the background antigens have thus been induced in the transgenic animals, the animals efficiently produce antibodies to target antigens.
    Type: Application
    Filed: June 4, 2003
    Publication date: October 6, 2005
    Inventors: Tatsuhiko Kodama, Kou-Ichi Jishage, Nobuo Kamada, Yoshiki Yamada