Abstract: Provision of an affinity carrier using a mutant VHH antibody. An affinity carrier comprising: a solid phase carrier; and an immunoglobulin-binding protein bound to the solid phase carrier; wherein the immunoglobulin-binding protein comprises a mutant VHH antibody or a fragment of the mutant VHH antibody that recognizes an epitope in at least one region selected from the group consisting of amino acids 127 to 184 of SEQ ID NO: 22 and amino acids 13 to 210 of SEQ ID NO: 23.

Abstract: A method and apparatus for filling bulk material, in which an objective filling weight for filling bulk material stored in a storage portion of a filling object is divided to a first stage objective filling weight and a second a second stage objective filling weight. The method consists of setting an opening/closing mechanism provided on the storage portion to a predetermined opening degree and filling the bulk material from the storage portion to the filling object until the first stage objective filling weight is reached, and then activating the opening/closing mechanism so as to close from the predetermined opening degree. A closing travel distance of the opening/closing mechanism in a certain minute time interval, and a filling weight of bulk material are then detected, and based on these detected values, the fluidity of the bulk material in such a minute time interval is calculated.

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin conditions by a device which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.