Patents by Inventor Nobuo Tsutsumi
Nobuo Tsutsumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9320728Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.Type: GrantFiled: June 27, 2014Date of Patent: April 26, 2016Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takahito Yoshizaki, Kouji Tanaka, Kazunosuke Aida, Terumitsu Kaiho, Nobuo Tsutsumi
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Patent number: 9084695Abstract: A pressure-sensitive adhesive tape package is provided. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, the adhesive tape being bent into a first portion and a second portion such that the adhesive agent layer faces outward. Moreover, the pressure-sensitive adhesive tape package can include a first release sheet releasably attached to the adhesive agent layer of the first portion of the adhesive tape, and a second release sheet releasably attached to the adhesive agent layer of the second portion of the adhesive tape to seal the adhesive tape with the first release sheet between the first and second release sheets. In this configuration, the conventionally existing package can be eliminated. Moreover, when the second release sheet is removed from the adhesive agent layer of the second portion of the adhesive tape, half of the adhesive agent layer is exposed.Type: GrantFiled: December 18, 2009Date of Patent: July 21, 2015Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Ohta, Nobuo Tsutsumi
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Publication number: 20150004215Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: June 27, 2014Publication date: January 1, 2015Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takahito YOSHIZAKI, Kouji Tanaka, Kazunosuke Aida, Terumitsu Kaiho, Nobuo Tsutsumi
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Patent number: 8877235Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: GrantFiled: June 21, 2013Date of Patent: November 4, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Kazunosuke Aida, Terumitsu Kaiho, Tetsurou Tateishi, Nobuo Tsutsumi
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Patent number: 8802134Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: GrantFiled: February 21, 2013Date of Patent: August 12, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi
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Publication number: 20140186428Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: a step A of obtaining an adhesive agent layer composition comprising oxybutynin hydrochloride as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, a sterol, an organic acid, and a tackifier; a step B of heating the adhesive agent layer composition at a temperature in a range from 55 to 70° C. for 1 to 24 hours; and a step C of cooling the heated adhesive agent layer composition to a temperature lower than room temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: June 21, 2013Publication date: July 3, 2014Inventors: Kazunosuke AIDA, Terumitsu KAIHO, Tetsurou TATEISHI, Nobuo TSUTSUMI
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Publication number: 20140161865Abstract: A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.Type: ApplicationFiled: February 21, 2013Publication date: June 12, 2014Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naruhito Higo, Tetsurou Tateishi, Takaaki Terahara, Kazunosuke Aida, Shigeki Hayashi, Nobuo Tsutsumi
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Patent number: 8382729Abstract: Provided is an adhesive patch including a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G?) of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37° C.Type: GrantFiled: January 22, 2009Date of Patent: February 26, 2013Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Tomomi Okada, Shigeo Ohta, Nobuo Tsutsumi
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Publication number: 20110253304Abstract: A pressure-sensitive adhesive tape package is provided. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, the adhesive tape being bent into a first portion and a second portion such that the adhesive agent layer faces outward. Moreover, the pressure-sensitive adhesive tape package can include a first release sheet releasably attached to the adhesive agent layer of the first portion of the adhesive tape, and a second release sheet releasably attached to the adhesive agent layer of the second portion of the adhesive tape to seal the adhesive tape with the first release sheet between the first and second release sheets. In this configuration, the conventionally existing package can be eliminated. Moreover, when the second release sheet is removed from the adhesive agent layer of the second portion of the adhesive tape, half of the adhesive agent layer is exposed.Type: ApplicationFiled: December 18, 2009Publication date: October 20, 2011Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shigeo Ohta, Nobuo Tsutsumi
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Patent number: 7910792Abstract: A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.Type: GrantFiled: August 17, 2006Date of Patent: March 22, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hideaki Iwahashi, Shigeo Ota, Nobuo Tsutsumi, Takafumi Miyachika
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Publication number: 20100318042Abstract: Provided is an adhesive patch including a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G?) of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37° C.Type: ApplicationFiled: January 22, 2009Publication date: December 16, 2010Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Tomomi Okada, Shigeo Ohta, Nobuo Tsutsumi
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Patent number: D618548Type: GrantFiled: May 23, 2008Date of Patent: June 29, 2010Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D619015Type: GrantFiled: September 26, 2008Date of Patent: July 6, 2010Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D621700Type: GrantFiled: May 24, 2008Date of Patent: August 17, 2010Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D621701Type: GrantFiled: May 24, 2008Date of Patent: August 17, 2010Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D628063Type: GrantFiled: May 23, 2008Date of Patent: November 30, 2010Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D634623Type: GrantFiled: August 16, 2010Date of Patent: March 22, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D634624Type: GrantFiled: August 16, 2010Date of Patent: March 22, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: D641621Type: GrantFiled: August 17, 2010Date of Patent: July 19, 2011Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Shigeo Kusumi, Nobuo Tsutsumi, Masakazu Shigiishi
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Patent number: RE45510Abstract: A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.Type: GrantFiled: November 28, 2012Date of Patent: May 5, 2015Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hideaki Iwahashi, Shigeo Ota, Nobuo Tsutsumi, Takafumi Miyachika