Abstract: To register a position and an angle of a scanning surface of an ultrasound probe easily and accurately. A phantom including two or more wires stretched in a non-parallel manner is disposed in a real space in which a position detection sensor is disposed. An ultrasound probe, to which a probe position detection marker is attached, is moved on the phantom in a parallel manner while keeping an orientation of a main plane of the ultrasound probe constant. Two or more ultrasound images of the phantom are acquired while detecting a position of the probe position detection marker in the real space with the position detection sensor. Positions of cross-sectional images of the two or more wires included in each of the two or more ultrasound images are obtained.

Abstract: The accuracy of an intervention site in surgery is predicted and the predicted intervention site is presented to a surgeon. A surgery support apparatus includes a prediction data generation unit that generates prediction data predicting an intervention site based on data before an intervention using an artificial intelligence algorithm. The artificial intelligence algorithm is an artificial intelligence algorithm learning an intervention site by analyzing data before the intervention and intervention site data for an object, and outputs coordinates, a region, or a shape of one point of the intervention site as prediction data. Data before the intervention used for learning of the artificial intelligence algorithm and input data input to the artificial intelligence algorithm to generate prediction data correspond to image data, a segment image, a feature point, etc. The prediction data is displayed on a display apparatus together with an image of a patient acquired in advance.

Abstract: To quickly and accurately register a surgical field image and a preoperative image with each other and display the surgical field image and the preoperative image. The invention extracts sulcus patterns included in the preoperative image, and extracts sulcus patterns included in the surgical field image of a brain of a patient during a surgical operation. The invention extracts, from the sulcus patterns of the preoperative image, a range that matches the sulcus patterns of the surgical field image, and calculates a conversion vector for converting the preoperative image to match the range with the surgical field image. The invention displaces the preoperative image by the conversion vector and displays the preoperative image on a connected display device.

Abstract: Two-step registration is performed so that a surface shape of a patient in real space accurately matches a surface shape in a medical image. The medical image of the patient is received from an imaging device, and position information is acquired for three or more regions on the surface of the patient and one representative position is set for each of the regions. Initial registration is performed using the information of the representative positions to establish association between the orientation of the patient in real space with the orientation of the patient image in the medical image. Then, detailed registration is performed to further establish the association, so that the surface shape of the patient represented by the positions of the plurality of points in the three or more regions matches the surface shape of the patient image in the medical image.

Abstract: The accuracy of an intervention site in surgery is predicted and the predicted intervention site is presented to a surgeon. A surgery support apparatus includes a prediction data generation unit that generates prediction data predicting an intervention site based on data before an intervention using an artificial intelligence algorithm. The artificial intelligence algorithm is an artificial intelligence algorithm learning an intervention site by analyzing data before the intervention and intervention site data for an object, and outputs coordinates, a region, or a shape of one point of the intervention site as prediction data. Data before the intervention used for learning of the artificial intelligence algorithm and input data input to the artificial intelligence algorithm to generate prediction data correspond to image data, a segment image, a feature point, etc. The prediction data is displayed on a display apparatus together with an image of a patient acquired in advance.

Abstract: To predict the movement and the deformation of an organ before and after an intervention, and improve the accuracy of position information on a surgical instrument or the like to be presented to an operator. Provided is a surgical support device that is provided with a storage device that stores therein, by analyzing data before and after an intervention to an object, an artificial intelligence algorithm having learned a deformational rule of the object that deforms due to the intervention, and a prediction data generation unit that generates, using the artificial intelligence algorithm, prediction data in which a shape of the object after the intervention is predicted on the basis of the data before the intervention.

Abstract: The medical image display device is provided with a medical image reading unit configured to read a medical image obtained by a medical image diagnostic apparatus, a projected image creating unit configured to project the medical image onto a projection plane to created the projected image, and a projected image display unit configured to display the projected image, wherein the projected image creating unit has a virtual liquid generating unit configured to generate virtual liquid, the light transmittance of which is not zero and a virtual liquid adding unit configured to add the virtual liquid to the surface of an organ within the medical image, and creates a projected image of the medical image to which the virtual liquid has been added.

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

Abstract: The medical image display device is provided with a medical image reading unit configured to read a medical image obtained by a medical image diagnostic apparatus, a projected image creating unit configured to project the medical image onto a projection plane to created the projected image, and a projected image display unit configured to display the projected image, wherein the projected image creating unit has a virtual liquid generating unit configured to generate virtual liquid, the light transmittance of which is not zero and a virtual liquid adding unit configured to add the virtual liquid to the surface of an organ within the medical image, and creates a projected image of the medical image to which the virtual liquid has been added.

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

Abstract: The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc.

Abstract: The preparation method of the powder of which dissolution rate improves is characterized by including of the process that slightly soluble drug having acidic group (e.g., 3-(5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-3,4-dihydronaphthalen-1-yl)propanoic acid etc.) is made to metal salt solution and is neutralized to precipitate. By the method of the present invention, since a powder of which specific surface area increases and dissolution rate improves can be obtained, it is excellent as a preparation method of drug bulk.

Abstract: The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc.

Abstract: A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

Abstract: An electronic parts mounting method in which chips in a plurality of parts feeders are picked up respectively by at least three nozzles, and a lowered mounting efficiency is avoided when any of the nozzles becomes bad, thereby mounting the chips on a board with a good operation efficiency. In a normal condition, the chips in the parts feeders are simultaneously picked up respectively by the first, second and third nozzles, and are transferred to and mounted on the board. When any of the three nozzles becomes bad, the mounting of the chips by this bad nozzle is stopped while the mounting of the chips by the other normal nozzles is effected as scheduled in a program, and thereafter those chips scheduled to be mounted by the bad nozzle are mounted by the normal nozzles. Therefore, the number of the pick-up operations is reduced as much as possible, so that the mounting efficiency can be enhanced.

Abstract: An electronic component mounting apparatus for determining whether or not a nozzle replacement operation is successfully performed. A horizontal array of nozzles are accommodated in the holder in a nozzle stocker, and a light emitting device and a light receiving device are arranged so that the light path between both runs above the nozzles. The nozzle stocker is arranged in a travel path of a feeding head. The nozzle mount of the feeding head returns a used nozzle into the holder or mounts a new nozzle thereon. When any nozzle remains lifted from the holder intercepting the light path, a returning operation of the used nozzle is determined to be a failure. When a nozzle replacement is performed, its success or failure is reliably determined by detecting a intercepting height of light and release height of light by the nozzle and nozzle mount, respectively.

Abstract: There is disclosed an electronic parts mounting method in which it is possible to avoid a pick-up mistake for electronic parts (chips) in simultaneously picking up the chips respectively stored in juxtaposed parts feeders by a plurality of nozzles provided to a transfer head. Nozzle position data of first, second and third nozzles 9a, 9b and 9c are beforehand obtained by a first camera, and pick-up positions of the chips in parts feeders 4 are obtained by a second camera. After picking up respectively the chips in the parts feeders 4 by the nozzles 9a to 9c it is judged whether or not there would be caused the pick-up mistake. When it is judged there is caused no pick-up mistake, a transfer head is moved to a position above a board and each of the chips is mounted to the board.