Patents by Inventor Nobutaka Fujii

Nobutaka Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10645823
    Abstract: An electronic device includes: a circuit board; a case within which the circuit board is provided and which has a plurality of first contact parts to contact with the circuit board; a cover which has a plurality of second contact parts to contact with the circuit board; a hook part which is provided to one of the case and the cover; and a receiving part which is provided to other of the case and the cover and which corresponds to the hook part, and the hook part engages with the receiving part, whereby the cover is fitted onto the case and the plurality of first contact parts of the case and the plurality of second contact parts of the cover hold and fix the circuit board interposed therebetween.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: May 5, 2020
    Assignee: DENSO TEN Limited
    Inventors: Nobutaka Watanabe, Yasuaki Takeda, Toshihiko Fujii
  • Publication number: 20190343607
    Abstract: To provide a pair of maxillary and mandibular coupled artificial tooth sets applicable to alveolar ridge shapes of an unspecified large number of edentulous patients and having all the parts of 14 teeth coupled into an ideal arch shape and in an ideal maxillomandibular occlusal contact relationship. The present invention provides a pair of maxillary and mandibular coupled artificial tooth sets clearly defining an arrangement region of all parts at the time of arrangement in virtual three-dimensional coordinates, a contact relationship between maxillary and mandibular artificial teeth, and a harmonizing contact/gliding relationship at the time of movement on a mean-value articulator. This enables provision of a high-quality complete denture in which an occlusal relationship required for a complete denture can be established in a short time regardless of a skill of a technician and a difference in shape of an alveolar ridge of an edentulous patient.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 14, 2019
    Inventors: Nobutaka WATANABE, Katsushi TAMAKI, Kunihiro FUJII, Hirokazu SATOH, Toshiyuki NAKATSUKA
  • Publication number: 20190313538
    Abstract: An electronic device includes: a circuit board; a case within which the circuit board is provided and which has a plurality of first contact parts to contact with the circuit board; a cover which has a plurality of second contact parts to contact with the circuit board; a hook part which is provided to one of the case and the cover; and a receiving part which is provided to other of the case and the cover and which corresponds to the hook part, and the hook part engages with the receiving part, whereby the cover is fitted onto the case and the plurality of first contact parts of the case and the plurality of second contact parts of the cover hold and fix the circuit board interposed therebetween.
    Type: Application
    Filed: February 14, 2019
    Publication date: October 10, 2019
    Applicant: DENSO TEN Limited
    Inventors: Nobutaka WATANABE, Yasuaki TAKEDA, Toshihiko FUJII
  • Patent number: 9034814
    Abstract: The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialization in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.
    Type: Grant
    Filed: May 21, 2006
    Date of Patent: May 19, 2015
    Assignees: Hadasit Medical Research Services and Development Ltd., Kyoto University
    Inventors: Amnon Peled, Nobutaka Fujii
  • Patent number: 8772297
    Abstract: The present invention provides a compound represented by the following formula (I) or a physiologically acceptable salt thereof, and use thereof for the prophylaxis or treatment of TGF-?-related diseases: wherein Y is a hydrogen atom and the like; R2 is and the like; R3 is —NR8—R9— and the like; R4, R5, R6 and R7 are the same or different and each is a hydrogen atom and the like; and X is and the like.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: July 8, 2014
    Assignee: Kyoto University
    Inventors: Hideaki Kakeya, Akira Hattori, Yasuaki Takasu, Nobutaka Fujii, Shinya Oishi, Soichi Kojima, Mitsuko Hara
  • Patent number: 8592379
    Abstract: The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is superior in blood stability, and has a cancer metastasis suppressive action or cancer growth suppressive action.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: November 26, 2013
    Assignees: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Nobutaka Fujii, Shinya Oishi, Kenji Tomita
  • Patent number: 8435939
    Abstract: The present invention provides novel polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, lysine, ornithine, citrulline, or alanine; A5 is a residue of tyrosine, phenylalanine, alanine, naphthylalanine, or citrulline; A7 is a lysine or arginine residue whose carboxyl group may be converted into amido; and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like), and methods of using same in the treatment of HIV.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: May 7, 2013
    Assignee: Biokine Therapeutics Ltd.
    Inventor: Nobutaka Fujii
  • Patent number: 8410059
    Abstract: Therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt are described. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: April 2, 2013
    Assignee: Biokine Therapeutics Ltd.
    Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
  • Publication number: 20130045977
    Abstract: The present invention provides a compound represented by the following formula (I) or a physiologically acceptable salt thereof, and use thereof for the prophylaxis or treatment of TGF-?-related diseases: wherein Y is a hydrogen atom and the like; R2 is and the like; R3 is —NR8—R9— and the like; R4, R5, R6 and R7 are the same or different and each is a hydrogen atom and the like; and X is and the like.
    Type: Application
    Filed: February 17, 2011
    Publication date: February 21, 2013
    Applicant: KYOTO UNIVERSITY
    Inventors: Hideaki Kakeya, Akira Hattori, Yasuaki Takasu, Nobutaka Fujii, Shinya Oishi, Soichi Kojima, Mitsuko Hara
  • Patent number: 8183212
    Abstract: The present invention provides a compound represented by the following formula (1); wherein R1 is an aryl group etc.; R2 is —CO—NH— etc.; R3 is a methyl group having an aromatic group or a cycloalkyl group; R4 is a hydrogen atom etc.; R5 is a methyl group having an aromatic group; and R6 is an amino group or an N-alkyl substituted amino group, having a low-molecular weight and a superior GPR54 agonist activity, and a pharmaceutical composition containing the compound.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: May 22, 2012
    Assignees: Kyoto University, Takeda Phamaceutical Company Limited
    Inventors: Nobutaka Fujii, Shinya Oishi, Kenji Tomita, Ayumu Niida
  • Publication number: 20110269686
    Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
    Type: Application
    Filed: July 8, 2011
    Publication date: November 3, 2011
    Applicant: BIOKINE THERAPEUTICS LTD.
    Inventors: Nobutaka FUJII, Hirokazu TAMAMURA, Akira HORI
  • Patent number: 8017585
    Abstract: Peptides, their amides, esters or salts, which have CXCR4 antagonistic action, have therapeutic effects for cancer and chronic rheumatoid arthritis.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: September 13, 2011
    Assignee: Biokine Therapeutics Ltd.
    Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
  • Publication number: 20110039786
    Abstract: The present invention provides a metastin derivative represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a pharmaceutical composition containing it. The metastin derivative or a salt thereof is superior in blood stability, and has a cancer metastasis suppressive action or cancer growth suppressive action.
    Type: Application
    Filed: April 28, 2009
    Publication date: February 17, 2011
    Applicants: KYOTO UNIVERSITY, TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Nobutaka Fujii, Shinya Oishi, Kenji Tomita
  • Publication number: 20110014649
    Abstract: The present invention relates to the production of an N36-binding peptide at low cost and in a large quantity utilizing a microorganism. More specifically, the present invention relates to a method for producing an N36-binding peptide comprising introducing a recombinant vector into which a DNA molecule encoding an N36-binding peptide that binds to an N36 protein derived from a retrovirus that causes immunodeficiency in a mammal has been incorporated into E. coli as a host to produce a transformant.
    Type: Application
    Filed: July 26, 2007
    Publication date: January 20, 2011
    Applicant: GEKKEIKAN SAKE CO., LTD.
    Inventors: Hiroko Tsutsumi, Hiroki Ishida, Hiromoto Hisada, Makiko Mizumoto, Yoji Hata, Nobutaka Fujii, Masao Matsuoka, Eiichi Kodama, Shinya Oishi
  • Publication number: 20100222256
    Abstract: The present invention provides novel polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, lysine, ornithine, citrulline, or alanine; A5 is a residue of tyrosine, phenylalanine, alanine, naphthylalanine, or citrulline; A7 is a lysine or arginine residue whose carboxyl group may be converted into amido; and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like), and methods of using same in the treatment of HIV.
    Type: Application
    Filed: August 25, 2009
    Publication date: September 2, 2010
    Inventor: Nobutaka Fujii
  • Publication number: 20100160241
    Abstract: The present invention provides a compound represented by the following formula (1); wherein R1 is an aryl group etc.; R2 is —CO—NH— etc.; R3 is a methyl group having an aromatic group or a cycloalkyl group; R4 is a hydrogen atom etc.; R5 is a methyl group having an aromatic group; and R6 is an amino group or an N-alkyl substituted amino group, having a low-molecular weight and a superior GPR54 agonist activity, and a pharmaceutical composition containing the compound.
    Type: Application
    Filed: October 24, 2006
    Publication date: June 24, 2010
    Applicant: Kyoto University
    Inventors: Nobutaka Fujii, Shinya Oishi, Kenji Tomita, Ayumu Niida
  • Publication number: 20100055088
    Abstract: The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialisation in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.
    Type: Application
    Filed: May 21, 2006
    Publication date: March 4, 2010
    Applicants: Hadasit Medical Research Services and Development Ltd., Kyoto University
    Inventors: Amnon Peled, Nobutaka Fujii
  • Patent number: 7595298
    Abstract: The present invention relates to a polypeptide represented by the formula: A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit-Cys-A7??(I) (wherein A1 represents a hydrogen atom or an arginine, lysine, ornithine, citrulline, alanine residue, etc.; A2 represents an aromatic amino acid residue; A3, A4 and A6 represent an arginine, lysine, ornithine, citrulline or alanine residue, A5 represents a tyrosine, phenylalanine, alanine, naphthylalanine or citrulline residue; A7 represents a lysine or arginine residue in which a carboxyl group may be amidated; X represents a D-ornithyl-proline, prolyl-D-ornithine, D-lysyl-proline residue, etc.; provided that either of A1, A3, A4, A5, A6 and A7 is an alanine residue, etc., or X is citrulline, etc.) or a salt thereof.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: September 29, 2009
    Assignee: Biokine Therapeutics Ltd.
    Inventor: Nobutaka Fujii
  • Publication number: 20090181897
    Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.
    Type: Application
    Filed: July 11, 2008
    Publication date: July 16, 2009
    Applicant: BIOKINE THERAPEUTICS LTD.
    Inventors: Nobutaka Fujii, Hirokazu Tamamura, Akira Hori
  • Patent number: 7495011
    Abstract: The present invention provides an anti-coronavirus agent including as an active ingredient as exemplified by nelfinavir and salts thereof, an anti-SARS agent including the anti-coronavirus agent, and a method of treating SARS using the anti-SARS agent.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 24, 2009
    Assignee: aRigen Pharmaceuticals, Inc.
    Inventors: Nobutaka Fujii, Naoki Yamamoto