Patents by Inventor Nobutaka HANAGATA

Nobutaka HANAGATA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunostimulating oligonucleotide complex
    Patent number: 10449212
    Abstract: Provided is an immunostimulating oligonucleotide that is suitable for industrial production and has an excellent type-I IFN inducing activity even when not modified to become a phosphorothioate. This linear double-stranded oligonucleotide contains 10-100 base pairs, wherein the single-stranded oligonucleotides constituting the double-stranded oligonucleotide each contain 2-20 phosphodiester-mediated cytosine-guanine (CpG) sequences, and at least 90% of the internucleotide bonds in each single-stranded oligonucleotide are phosphodiester bonds.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: October 22, 2019
    Assignees: NATIONAL INSTITUTE FOR MATERIALS SCIENCE, DENKA COMPANY LIMITED
    Inventors: Nobutaka Hanagata, Hiroshi Otsuka, Takafumi Harada
  • IMMUNOSTIMULATING OLIGONUCLEOTIDE COMPLEX
    Publication number: 20180193371
    Abstract: Provided is an immunostimulating oligonucleotide that is suitable for industrial production and has an excellent type-I IFN inducing activity even when not modified to become a phosphorothioate. This linear double-stranded oligonucleotide contains 10-100 base pairs, wherein the single-stranded oligonucleotides constituting the double-stranded oligonucleotide each contain 2-20 phosphodiester-mediated cytosine-guanine (CpG) sequences, and at least 90% of the internucleotide bonds in each single-stranded oligonucleotide are phosphodiester bonds.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 12, 2018
    Inventors: Nobutaka HANAGATA, Hiroshi OTSUKA, Takafumi HARADA