Patents by Inventor Nobutaka Tani
Nobutaka Tani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6037458Abstract: An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely.Type: GrantFiled: September 22, 1992Date of Patent: March 14, 2000Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Fumiyasu Hirai, Nobutaka Tani
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Patent number: 5902877Abstract: The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.Type: GrantFiled: May 20, 1996Date of Patent: May 11, 1999Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Fumiyasu Hirai, Nobutaka Tani, Takamune Yasuda, Takashi Asahi, Yuji Okubo, Osamu Odawara, Michio Nomura
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Patent number: 5866387Abstract: There is provided a method for immobilizing a ligand by reacting a solvent-insoluble carrier having aldehyde group with a compound shown by the general formula: ##STR1## wherein X is --S-- or --O--, R.sup.1, R.sup.2 and R.sup.6 are the same or different, each of which is hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R.sup.3 is hydrogen atom or a substituent wherein an atom adjacent to nitrogen atom shown in the above-mentioned general formula has no unsaturated bond, R.sup.4, R.sup.5 and R.sup.7 are arbitrary substituents; provided that only one partial chemical structure of HX--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above or HX--C--C--C--NHR.sup.3 wherein X and R.sup.3 are the same as defined above is contained in one compound described above by which, a ligand or a compound to which a ligand is bonded can react specifically and effectively with aldehyde group in a solvent-insoluble carrier at a prescribed position to form a stable bond.Type: GrantFiled: August 28, 1997Date of Patent: February 2, 1999Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Eiji Ogino, Kazuo Suzuki, Nobutaka Tani
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Patent number: 5854368Abstract: A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.Type: GrantFiled: December 30, 1996Date of Patent: December 29, 1998Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Koji Iritani, Tetsuya Kawasaki, Nobutaka Tani, Shigeki Masuda, Yoshiaki Yano
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Patent number: 5821193Abstract: An adsorbent for removing ketoamine-containing protein, which comprises carrying a compound having a terminal functional group of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is an organic group and X is 0 or 1, on a porous water-insoluble carrier, a process for removing ketoamine-containing protein by employing the above adsorbent, a process for preventing or treating for diabetic complication by removing ketoamine-containing protein with the above adsorbent and an adsorber for removing ketoamine-containing protein.Type: GrantFiled: December 6, 1995Date of Patent: October 13, 1998Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Nobutaka Tani, Eiji Ogino
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Patent number: 5644012Abstract: A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.Type: GrantFiled: November 16, 1992Date of Patent: July 1, 1997Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Koji Iritani, Tetsuya Kawasaki, Nobutaka Tani, Shigeki Masuda, Yoshiaki Yano
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Patent number: 5593814Abstract: A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner.Type: GrantFiled: September 19, 1994Date of Patent: January 14, 1997Assignee: Kanegafuchi kagaku kogyo Kabushiki KaishaInventors: Takehisa Matsuda, Kazuhiko Inoue, Nobutaka Tani
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Patent number: 5576020Abstract: A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.Type: GrantFiled: April 14, 1995Date of Patent: November 19, 1996Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Koji Iritani, Tetsuya Kawasaki, Nobutaka Tani, Shigeki Masuda, Yoshiaki Yano
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Patent number: 5302393Abstract: A method for inhibiting decomposition and/or degradation of an implantation polymeric material in the living body, which comprises allowing dipyridamole and/or a salt or a derivative thereof as an active component to exist in the vicinity of an implantation polymeric material implanted in the living body; an inhibitor effective for inhibiting biological decomposition and/or degradation of a polymeric material implanted in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component; and an implantation polymeric material which contains dipyridamole and/or a salt or a derivative thereof as an active component.Type: GrantFiled: July 9, 1992Date of Patent: April 12, 1994Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Hiroshi Matsumoto, Kensuke Kondo, Kazuhiko Inoue, Nobutaka Tani
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Patent number: 5258503Abstract: An adsorbent for an autoantibody or immune complex produced by combining an autoantibody with its homologous antigen, which comprises a water-insoluble porous material and a compound having an anionic functional group immobilized onto said material, an apparatus for removing an autoantibody or immune complex thereof using the above-mentioned adsorbent and a method for removing an autoantibody or immune complex thereof from body fluid by passing body fluid through the above-mentioned removing apparatus. According to the present invention, the autoantibody or immune complex thereof can be selectively removed from body fluid without removing useful components in body fluid.Type: GrantFiled: April 13, 1992Date of Patent: November 2, 1993Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Ryuichi Yokohari, Shinichi Aotsuka, Makiko Kinoshita, Takashi Funahashi, Nobutaka Tani
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Patent number: 5240747Abstract: A process for modifying the surface of a material such as plastics, metals, glasses and ceramics which comprises the steps of (1) coating a compound having at least one azido group on the surface of the material to be modified, (2) making a modifier substance to be fixed for the modification exist on or in the coated surface, and (3) irradiating ultraviolet rays to the coated surface to fix the modifier substance to the coated surface, wherein various compounds can be used as the modifier for converting the characteristics of the material surface to the desired characteristics without previously treating them, and various materials can be easily modified with a firm fixing of the modifier.Type: GrantFiled: August 2, 1991Date of Patent: August 31, 1993Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Takehisa Matsuda, Takashi Sugawara, Kazuhiko Inoue, Nobutaka Tani
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Patent number: 5216127Abstract: An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.Type: GrantFiled: July 12, 1991Date of Patent: June 1, 1993Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Fumiyasu Hirai, Nobutaka Tani
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Patent number: 5202227Abstract: A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner.Type: GrantFiled: June 1, 1990Date of Patent: April 13, 1993Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Takehisa Matsuda, Kazuhiko Inoue, Nobutaka Tani
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Patent number: 5128170Abstract: A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device's medical functional capability and economical efficiency.Type: GrantFiled: May 9, 1990Date of Patent: July 7, 1992Assignee: Kanegafunchi Kagaku Kogyo Kabushiki KaishaInventors: Takehisa Matsuda, Kazuhiko Inoue, Nobutaka Tani
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Patent number: 4814077Abstract: An adsorbent for lipoproteins which is a water-insoluble matrix having, on at least a part of the surface thereof, a group of the formula --NR.sup.1 R.sup.2 wherein R.sup.1 is hydrogen, methyl group or ethyl group; R.sup.2 is an atomic group having an aromatic ring satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula R.sup.2 H is from 0 to 3.2 and an apparatus for removing lipoproteins using the above adsorbent. The lipoprotein adsorbent has such advantages as a low cost, a good stability and a sufficient adsorption selectivity for adsorbing LDL and VLDL in a fluid containing lipoproteins.Type: GrantFiled: February 9, 1987Date of Patent: March 21, 1989Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Shigeo Furuyoshi, Nobutaka Tani
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Patent number: 4744899Abstract: A process for steam-sterilizing an adsorbent for use in extracorporeal circulation treatment comprising a water-insoluble support and a sulfated polysaccharide immobilized on the support, characterized by sterilizing the adsorbent in an aqueous medium maintainted at pH 5 to 9, whereby the sulfated polysaccharide is prevented from releasing from the support and being deactivated. When the water-insoluble support/sulfated polysaccharide adsorbent is packed in a column with an aqueous buffer solution having a pH 5 to 9 to provide an adsorption column for use in extracorporeal circulation treatment, release and deactivation of the sulfated polysaccharide are prevented and the column can be stored for a long term.Type: GrantFiled: October 21, 1985Date of Patent: May 17, 1988Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Nobutaka Tani, Tsutomu Okuyama, Shigeo Furuyoshi
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Patent number: 4721730Abstract: An adsorbent for .beta..sub.2 -microglobulin and immunoglobulin L-chain suitable for use in an extracorporeal circulation treatment, which comprises a porous water-insoluble carrier and a compound immobilized onto said carrier, said compound satisfying that the value of log P, in which P is a partition coefficient in an octanol-water system, is not less than 2.5. The adsorbent is inexpensive, and efficiently adsorb and remove .beta..sub.2 -microglobulin and immunoglobulin L-chain contained in a body fluid.Type: GrantFiled: May 29, 1987Date of Patent: January 26, 1988Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Shigeo Furuyoshi, Eiji Ogino, Nobutaka Tani
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Patent number: 4696670Abstract: A method for treating circulatory fluid constituents with an apparatus which includes a first switching device which connects the upstream side of a first circulatory fluid treatment device with a flow of circulatory fluid from a source, and a second switching device which connects the downstream side of the first circulatory fluid treatment device with a destination of the circulatory fluid.Type: GrantFiled: November 6, 1985Date of Patent: September 29, 1987Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Michikazu Ohnishi, Nobutaka Tani
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Patent number: 4656261Abstract: A lipoprotein adsorbent for use in extracorporeal circulation treatment which is made of a water-insoluble porous hard gel which has an exclusion limit value from 10.sup.6 to 10.sup.9 measured by using glubular proteins and comprises a polymer having hydroxy group in at least a part of the molecule, at least a part of hydroxy groups on the surface of said gel being converted to sulfates. By using the adsorbent of the present invention, LDL and VLDL can be selectively and effectively removed from the body fluids of the patient. Further, the adsorbent of the present invention can be prepared in a lower cost than the adsorbent based on the principle of the affinity chromatography, in which a relatively expensive ligand is employed.Type: GrantFiled: October 21, 1985Date of Patent: April 7, 1987Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Shigeo Furuyoshi, Nobutaka Tani
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Patent number: 4654420Abstract: A lipoprotein adsorbent for use in extracorporeal circulation treatment which is made of a water-insoluble porous hard gel which has an exclusion limit value from 10.sup.6 to 10.sup.9 measured by using glubular proteins and comprises a polymer having hydroxy group in at least a part of the molecule, at least a part of hydroxy groups on the surface of said gel being converted to sulfates. By using the adsorbent of the present invention, LDL and VLDL can be selectively and effectively removed from the body fluids of the patient. Further, the adsorbent of the present invention can be prepared in a lower cost than the adsorbent based on the principle of the affinity chromatography, in which a relatively expensive ligand is employed.Type: GrantFiled: June 23, 1986Date of Patent: March 31, 1987Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Shigeo Furuyoshi, Nobutaka Tani