Patents by Inventor Nobutake Kimura

Nobutake Kimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050096262
    Abstract: This invention relates to a Helicobacter pylori adhesion inhibitor that is capable of eliminating Helicobacter pylori associated with the development of peptic ulcer from the stomach, a method for producing the same, and pharmaceutical compositions and foods for preventing or treating diseases associated with Helicobacter pylori comprising such Helicobacter pylori adhesion inhibitor. The inhibitor of the present invention has excellent activity of eradicating Helicobacter pylori and is highly safe. Accordingly, pharmaceutical compositions and foods comprising the same are highly useful for the prevention or treatment of the aforementioned diseases.
    Type: Application
    Filed: January 27, 2003
    Publication date: May 5, 2005
    Inventors: Shigeru Hiramoto, Yoshiro Morishita, Nobutake Kimura, Yoshikatsu Kodama
  • Patent number: 6828298
    Abstract: An inhibitor of Helicobacter pylori colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to H. pylori urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which H. pylori urease is immobilized. The glycoprotein is able to effectively inhibit H. pylori colonization, so is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: December 7, 2004
    Assignees: Ghen Corporation, Nisshin Pharma Inc.
    Inventors: Yoshikatsu Kodama, Nobutake Kimura
  • Patent number: 6797268
    Abstract: An inhibitor composition of Helicobacter pylori adhesion in the stomach comprises (1) anti-urease antibodies obtained from eggs laid by hens which have been immunized against H. pylori urease and (2) an inhibitor of gastric acid secretion. This inhibitor is capable of completely eliminating H. pylori from the stomach, so it is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: September 28, 2004
    Assignees: Ghen Corporation, Nisshin Pharma Inc.
    Inventors: Yoshikatsu Kodama, Nobutake Kimura
  • Patent number: 6793921
    Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori. At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: September 21, 2004
    Assignees: Nisshin Pharma Inc., Ghen Corporation
    Inventors: Yoshikatsu Kodama, Faustino C. Icatlo, Jr., Nobutake Kimura, Masato Ariga
  • Publication number: 20020197259
    Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori. At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.
    Type: Application
    Filed: June 24, 2002
    Publication date: December 26, 2002
    Inventors: Yoshikatsu Kodama, Faustino C. Icatlo, Nobutake Kimura, Masato Ariga
  • Patent number: 6419926
    Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori . At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: July 16, 2002
    Assignees: Ghen Corporation, Nisshin Pharma Inc.
    Inventors: Yoshikatsu Kodama, Faustino C. Icatlo, Jr., Nobutake Kimura, Masato Ariga
  • Publication number: 20020039579
    Abstract: An inhibitor composition of Helicobacter pylori adhesion in the stomach comprises (1) anti-urease antibodies obtained from eggs laid by hens which have been immunized against H. pylori urease and (2) an inhibitor of gastric acid secretion. This inhibitor is capable of completely eliminating H. pylori from the stomach, so it is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers.
    Type: Application
    Filed: July 13, 2001
    Publication date: April 4, 2002
    Inventors: Yoshikatsu Kodama, Nobutake Kimura
  • Publication number: 20010044120
    Abstract: An inhibitor of Helicobacter pylori colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to H. pylori urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which H. pylori urease is immobilized. The glycoprotein is able to effectively inhibit H. pylori colonization, so is useful for the prevention or treatment of diseases caused by infection of H. pylori such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.
    Type: Application
    Filed: April 13, 2001
    Publication date: November 22, 2001
    Inventors: Yoshikatsu Kodama, Nobutake Kimura
  • Publication number: 20010021393
    Abstract: The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of Helicobacter pylori as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of Helicobacter pylori as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of Helicobacter pylori. At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.
    Type: Application
    Filed: April 8, 1998
    Publication date: September 13, 2001
    Inventors: YOSHIKATSU KODAMA, FAUSTINO C. ICATLO, NOBUTAKE KIMURA, MASATO ARIGA
  • Patent number: 6235709
    Abstract: The present invention provides a safe and effective inhibitor of Helicobacter pylori colonization in the stomach and a food containing the inhibitor. The inhibitor of the present invention comprises as an active ingredient a mucin, especially a mucin from milk of a cow or a mucin from albumen of an egg and is useful for the prevention or treatment of diseases caused by infection of Helicobacter pylori such as peptic ulcers.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: May 22, 2001
    Assignee: Ghen Corporation
    Inventors: Yoshikatsu Kodama, Nobutake Kimura
  • Patent number: 6040495
    Abstract: A hairless mouse designated NS:Hr/ICR is sensitive to H. pylori. This NS:Hr/ICR hairless mouse can be easily infected with H. pylori in its alimentary canal, and is therefore useful as an experimental animal model for H. pylori infection.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: March 21, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Nobutake Kimura, Masato Ariga, Hirohito Yamakawa, Yoshio Nakagawa, Akio Shimizu
  • Patent number: 4837018
    Abstract: A vaccine useful for the protection of poultry from colibacillosis infections which comprises as an active ingredient pre-inactivated and ultrasonicated E. coli cells, and a method for protecting poultry from colibacillosis infections which comprises inoculating said vaccine into poultry through cloaca.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: June 6, 1989
    Assignees: Shionogi & Co., Ltd., Nisshin Flour Milling Co., Ltd.
    Inventors: Takao Konishi, Giichi Sugimori, Kazuyoshi Kato, Nobutake Kimura, Kenji Shibata