Patents by Inventor Nobutoshi Yamada
Nobutoshi Yamada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5519119Abstract: A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of Arg-Gly-Asp and from 3 to 16 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.Type: GrantFiled: December 21, 1992Date of Patent: May 21, 1996Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Nobutoshi Yamada, Masanari Kato, Keizo Miyata, Yoshiyuki Aoyama, Hiroshi Shikama
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Patent number: 5446129Abstract: A peptide having the formula:A--B--Cwherein A is a hydrogen atom, Glu, Phe Glu--, Phe Phe Glu-- or an amino acid sequence as shown by SEQ ID NO:1 in the Sequence Listing, B is an amino acid sequence as shown by SEQ ID NO:2, and C is a hydroxyl group, Glu, --Glu Ile, --Glu Ile Ile or an amino acid sequence as shown by SEQ ID NO:3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16, and containing from 6 to 25 amino acids; or its salt.Type: GrantFiled: August 4, 1994Date of Patent: August 29, 1995Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Toru Mori, Hideo Sugawa, Nobutoshi Yamada, Yoshimichi Ueda
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Patent number: 5247070Abstract: A polypeptide which is a tumor necrosis factor polypeptide having an amino acid sequence represented by from the 1st Ser to the 155th Leu as shown by SEQ ID NO:1 in the Sequence Listing, or its mutein, wherein the amino acid sequence of the 1st Ser to the 8th Asp of the SEQ ID NO:1 or the corresponding amino acid sequence of the mutein is replaced by an amino acid sequence containing at least one amino acid sequence of cell-adherent peptide of laminin and from 5 to 30 amino acids. Also disclosed are a recombinant plasmid containing a DNA encoding such a polypeptide, a recombinant microbial cell transformed by such a recombinant plasmid, a process for producing the polypeptide, a pharmaceutical composition comprising the polypeptide as an active ingredient, and a DNA for the polypeptide.Type: GrantFiled: September 20, 1991Date of Patent: September 21, 1993Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Nobutoshi Yamada, Masanari Kato, Keizo Miyata, Yoshiyuki Aoyama, Hiroshi Shikama
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Patent number: 5149793Abstract: Exo-3',4'-O-benzylidene-3"-dimethylchartreusin (exo-BDMC) or its salts and 3"-demethylchartreusin (3"-DMC) or its salts are provided according to the present invention. Exo-BDMC and its salts are useful for antitumorous agents and antibacterial agents. 3"-DMC and its salts are useful as starting materials for producing exo-BDMC.Type: GrantFiled: January 29, 1990Date of Patent: September 22, 1992Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Nobutoshi Yamada, Hideo Sugi, Sadanori Mizukoshi, Kenji Kon, Taiji Katayama
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Patent number: 5147686Abstract: Antimicrobial powders are obtained by suppporting at least one antimicrobial metal of copper, zinc and alloys thereof on the surface of hydrous titanium oxide or titanium oxide particles by electroless plating, vapor deposition, compression mixing, mixing and reducing, and thermal decomposition of a compound. These powders are used to provide antimicrobial resin compositions, antimicrobial rubber compositions, antimicrobial glass compositions and antimicrobial coating compositions.Type: GrantFiled: January 9, 1991Date of Patent: September 15, 1992Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Kenichi Ichimura, Hajime Murakami, Nobutoshi Yamada, Sadanori Mizukoshi
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Patent number: 5145775Abstract: A polyhedrin gene of Spodoptera litura nuclear polyhedrosis virus (SlNPV C-411) has the following restriction enzyme cleavage map and about 3 kilobase pairs: ##STR1## At least a part of said polyhedrin gene can be substituted by a gene coding for a useful substance to construct a vector and a recombinant virus, and it is possible to produce a useful substance such as a peptide, protein or glycoprotein by culturing a cell infected with the recombinant virus.Type: GrantFiled: February 23, 1990Date of Patent: September 8, 1992Assignee: Research Association for Biotechnology of Agricultural ChemicalsInventors: Nobutoshi Yamada, Norifusa Matsuo, Takaaki Araki
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Patent number: 5116949Abstract: A benzoyl urea compound-albumin complex comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom and A is CH or a nitrogen atom, and albumin.Type: GrantFiled: August 31, 1989Date of Patent: May 26, 1992Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Tsunetaka Nakajima, Tadao Okamoto, Nobuo Kondo, Masahiro Watanabe, Koichi Yamauchi, Kazumasa Yokoyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 5102884Abstract: A substituted benzoylurea compound of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a halogen atom or a nitro group, each of R.sup.2 and R.sup.3 is a hydrogen atom, an alkyl group, --COR.sup.6 (wherein R.sup.6 is an alkyl group or an alkoxy group) or --SO.sub.2 R.sup.6 (wherein R.sup.6 is as defined above), or R.sup.2 and R.sup.3 may form together with the adjacent nitrogen atom a heterocyclic ring, R.sup.4 is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group or a nitro group, and R.sup.5 is a halogen atom, a nitro group or a substituted or unsubstituted alkyl group, or its salt.Type: GrantFiled: July 19, 1990Date of Patent: April 7, 1992Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi, Hiroshi Okada
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Patent number: 5098907Abstract: A powdery pharmaceutical composition comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is CH or a nitrogen atom, as an active ingredient, a nonionic surfactant as a dispersant, at least one member selected from the group consisting of sugar, sugar-alcohol and a nonionic surfactant as a disintegrant, and anhydrous silicic acid as a fluidizer.Type: GrantFiled: January 23, 1990Date of Patent: March 24, 1992Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Masahiro Kikuchi, Tsunetaka Nakajima, Masahiro Watanabe, Kouichi Yamauchi, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 5064945Abstract: This invention relates to a novel chartreusin derivative of the general formula (I): ##STR1## and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to an antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.Type: GrantFiled: October 27, 1989Date of Patent: November 12, 1991Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Nobutoshi Yamada, Hideo Sugi, Kenji Kon
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Patent number: 5002952Abstract: A pharmaceutical composition comprising a benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH--group or a nitrogen atom, and a nonionic surfactant.Type: GrantFiled: July 27, 1989Date of Patent: March 26, 1991Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 4987135Abstract: A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R.sup.1 is --X.sup.1 Z.sup.1 (X.sup.1 is an oxygen atom or a sulfur atom and Z.sup.1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group), --COZ.sup.1 group (Z.sup.1 is as defined above), ##STR3## group (Z.sup.1 is as defined above, Z.sup.2 is --CO.sub.2 Z.sup.3 wherein Z.sup.3 is the same as Z.sup.1, or --SO.sub.2 Z.sup.3 wherein Z.sup.3 is as defined above and n is 0 or 1), ##STR4## (Z.sup.1 and Z.sup.3 are as defined above) or ##STR5## (X.sup.2, X.sup.3 and X.sup.4 are, respectively, an oxygen atom or a sulfur atom and Z.sup.4 and Z.sup.5 are the same as Z.sup.1), and R.sup.3 is a nitro group or ##STR6## (R.sup.4 and R.sup.Type: GrantFiled: March 16, 1989Date of Patent: January 22, 1991Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi, Hiroshi Okada
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Patent number: 4983605Abstract: A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.Type: GrantFiled: October 20, 1987Date of Patent: January 8, 1991Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Masahiro Kikuchi, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 4927919Abstract: This invention relates to a novel chartreusin derivative of the general formula (I): ##STR1## and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.Type: GrantFiled: October 23, 1986Date of Patent: May 22, 1990Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Nobutoshi Yamada, Hideo Sugi, Kenji Kon
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Patent number: 4904668Abstract: A benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, or the formula: ##STR2## wherein each of X.sub.1 is X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, characterized in that its average particle size is not larger than 1 .mu.m.Type: GrantFiled: September 25, 1987Date of Patent: February 27, 1990Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Masahiro Kikuchi, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 4863924Abstract: An N-benzoyl urea compound having the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is ##STR2## wherein Y.sub.1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y.sub.2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is .dbd.CH-- or a nitrogen atom, provided that one of A and B is .dbd.CH-- and the other is a nitrogen atom, with the provisos (1) that when Q is ##STR3## where when X is a hydrogen atom and Y.sub.1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is ##STR4## wherein A is a nitrogen atom and Y.sub.1 is a trifluoromethyl group, Y.sub.Type: GrantFiled: December 8, 1986Date of Patent: September 5, 1989Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi, Hiroshi Okada
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Patent number: 4849425Abstract: A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.Type: GrantFiled: January 30, 1986Date of Patent: July 18, 1989Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross CorporationInventors: Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Tadakazu Suyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
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Patent number: 4845093Abstract: An N-benzoyl-N'-pyridazinyloxyphenyl urea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom or a methyl group which may be substituted by fluorine, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, provided that when X.sub.1 is a hydrogen atom and X.sub.2 is a hydrogen atom or a halogen atom, Y is a methyl group which may be substituted by fluorine and/or Z is a hydrogen atom or a trifluoromethyl group. The compound is useful as an active ingredient for an antitumorous composition.Type: GrantFiled: October 19, 1987Date of Patent: July 4, 1989Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi, hiroshi Okada
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Patent number: 4760136Abstract: This invention relates to a novel chartreusin derivative of the general formula (I): ##STR1## and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation and the site of drug administration are different. This invention further relates to a antitumorous composition containing the above-mentioned compound as active ingredient. This invention furthermore relates to a process for producing the above-mentioned chartreusin derivative or salt thereof.Type: GrantFiled: April 23, 1985Date of Patent: July 26, 1988Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Hiroyuki Mori, Nobutoshi Yamada, Hideo Sugi, Kenji Kon
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Patent number: 4727077Abstract: A benzoyl urea compound having the formula: ##STR1## wherein A is a bromine atom or a chlorine atom.Type: GrantFiled: January 29, 1986Date of Patent: February 23, 1988Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi, Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama