Patents by Inventor Nobuyasu HORI
Nobuyasu HORI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11285077Abstract: A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.Type: GrantFiled: July 19, 2017Date of Patent: March 29, 2022Assignee: SYSMEX CORPORATIONInventors: Ayato Tagawa, Junko Kojima, Nobuyasu Hori, Kenji Akama, Masaya Okada, Kunpeng Cai, Samiko Hosoya, Shigeki Iwanaga
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Patent number: 11047776Abstract: Disclosed is a liquid sending method using a sample processing chip having a flow path into which a plurality of liquids flow, and the method includes: sending, into the flow path, a first liquid held in a liquid holding portion provided in the sample processing chip by applying pressure to the liquid holding portion; sending, into the flow path, a second liquid in a storage portion provided in a liquid sending device connected to the sample processing chip, through an injection hole provided in the sample processing chip, by applying pressure to the storage portion; and forming, in the flow path, a fluid containing the first liquid having been sent from the liquid holding portion, and the second liquid having been sent through the injection hole.Type: GrantFiled: February 26, 2018Date of Patent: June 29, 2021Assignee: Sysmex CorporationInventors: Nobuhiro Kitagawa, Yoshinobu Miura, Michitaka Notoya, Shuji Yamashita, Nobuyasu Hori
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Publication number: 20190380329Abstract: The present invention relates to a perfusion device and a perfusion method for culturing an undifferentiated cell using an organ or tissue extracted from a living body.Type: ApplicationFiled: August 27, 2019Publication date: December 19, 2019Applicant: SYSMEX CORPORATIONInventors: Nobuyasu HORI, Shingo FUJIYAMA
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Publication number: 20190231234Abstract: The in-vivo component measuring apparatus 1 for measuring components contained in interstitial fluid collected from a subject is provided. The apparatus includes a setting unit in which is installed an interstitial fluid collector that collects interstitial fluid, a glucose sensor for acquiring a signal reflecting the amount of the measurement target component contained in the interstitial fluid when in a state of contact with the interstitial fluid collector, and a moving unit that brings the glucose sensor into contact with the interstitial fluid collector installed in the setting unit by changing the relative position between the setting unit and the glucose sensor to a predetermined positional relationship.Type: ApplicationFiled: January 29, 2019Publication date: August 1, 2019Inventors: Junko Kojima, Kenichi Uchiyama, Kazutoshi Tokunaga, Nobuyasu Hori, Yu Morishita
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Patent number: 10267759Abstract: Disclosed is a method of detecting a test substance contained in a sample using a working electrode and a counter electrode. The method comprises (A) forming a complex on the working electrode, the complex comprising the test substance and a metal particle; (B) washing the working electrode; (C) adding a measurement solution to the working electrode and measuring a current, voltage or electric charge from the metal on the working electrode in the measurement solution by electrochemical measurement; and (D) detecting the test substance in the sample based on a measurement result obtained in the step (C). In the method, the step (B) comprises washing the working electrode using a measurement solution having the same composition as the composition of the measurement solution used in the step (C).Type: GrantFiled: October 27, 2015Date of Patent: April 23, 2019Assignee: SYSMEX CORPORATIONInventors: Nobuyasu Hori, Yuichi Yasuda, Hiroya Kirimura, Yuzuru Takamura, Miyuki Chikae
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Patent number: 10184109Abstract: Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells introduced to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate, thereby obtaining differentiated cells and/or differentiated cell products; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.Type: GrantFiled: March 30, 2015Date of Patent: January 22, 2019Assignee: SYSMEX CORPORATIONInventors: Eiji Kobayashi, Toshiyuki Sato, Kenji Akama, Nobuyasu Hori, Masaki Shibayama, Yuki Aihara, Masakazu Kadowaki
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Publication number: 20180246020Abstract: Disclosed is a liquid sending method using a sample processing chip having a flow path into which a plurality of liquids flow, and the method includes: sending, into the flow path, a first liquid held in a liquid holding portion provided in the sample processing chip by applying pressure to the liquid holding portion; sending, into the flow path, a second liquid in a storage portion provided in a liquid sending device connected to the sample processing chip, through an injection hole provided in the sample processing chip, by applying pressure to the storage portion; and forming, in the flow path, a fluid containing the first liquid having been sent from the liquid holding portion, and the second liquid having been sent through the injection hole.Type: ApplicationFiled: February 26, 2018Publication date: August 30, 2018Inventors: Nobuhiro KITAGAWA, Yoshinobu MIURA, Michitaka NOTOYA, Shuji YAMASHITA, Nobuyasu HORI
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Publication number: 20180055424Abstract: Disclosed are a novel means capable of accurately calculating the amount of in-vivo components as a test substance, and its uses. A sensor assembly 20 includes an electrochemical sensor 30 for measuring a test substance percutaneously extracted from a living body, and a processor 115a for calculating the intensity of the background signal at the measurement time point of the test substance after the elapse of the predetermined time based on the change over time of the intensity of the background signal measured within a predetermined time before measurement of the test substance by the electrochemical sensor 30. In this way, the amount of the in-vivo component as the test substance can be accurately calculated since the calculated value of the intensity of the background signal to be subtracted from the unprocessed signal including the signal attributable to the test substance can be obtained.Type: ApplicationFiled: August 29, 2017Publication date: March 1, 2018Inventors: Nobuyasu HORI, Chihiro SUMINAKA, Junko KOJIMA
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Publication number: 20180030499Abstract: In a hydrogen peroxide electrode 100 used as a working electrode 30 of an enzyme sensor 20, an intermediate layer 101 containing particles and a retentive substance for holding the particles inside the retentive substance are provided on a substrate 21, and an electrode layer 107 is provided on the intermediate layer 101. In this way, according to the hydrogen peroxide electrode 100, hydrogen peroxide can be detected with high sensitivity even when an applied voltage that is not susceptible to interference by interference substances present in the living body is used.Type: ApplicationFiled: July 26, 2017Publication date: February 1, 2018Inventors: Nobuyasu HORI, Junko KOJIMA, Yu MORISHITA
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Publication number: 20180021219Abstract: A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.Type: ApplicationFiled: July 19, 2017Publication date: January 25, 2018Inventors: Ayato TAGAWA, Junko KOJIMA, Nobuyasu HORI, Kenji AKAMA, Masaya OKADA, Kunpeng CAI, Samiko HOSOYA, Shigeki IWANAGA
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Publication number: 20180011054Abstract: Provided is a method for detecting a test substance. In this method, metal is deposited or a complex containing a test substance and a metal particle is immobilized on a working electrode on an electrode substrate including the working electrode and a counter electrode. An oxidation potential is applied to the working electrode to generate metal ions, then a reduction potential is applied to a portion having an area smaller than an area of the portion to which an oxidation potential is applied in the working electrode to deposit metal on the surface of the portion to which the reduction potential is applied, and current, voltage or charge caused by the metal deposited is measured to detect metal ions or a test substance.Type: ApplicationFiled: July 18, 2017Publication date: January 11, 2018Applicant: SYSMEX CORPORATIONInventors: Nobuyasu HORI, Hiroya KIRIMURA, Yuzuru TAKAMURA, Miyuki CHIKAE
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Patent number: 9610066Abstract: Disclosed is a method of collecting cells including the steps of: preparing a processed-bone comprising a bone extracted from a living body, a covering agent and first and second holes, wherein an outer surface of the bone is covered with the covering agent attached to the outer surface of the bone, and the first and second holes penetrate through the covering agent and the outer surface of the bone into the interior of the bone; introducing a liquid into the processed-bone from the first hole; and collecting a cell-containing liquid from the second hole.Type: GrantFiled: May 27, 2015Date of Patent: April 4, 2017Assignee: SYSMEX CORPORATIONInventors: Kenji Akama, Nobuyasu Hori
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Publication number: 20160278365Abstract: Disclosed is an organ perfusion method including introducing a perfusion solution into an organ extracted from the living body and deriving the perfusion solution from the organ, wherein the organ and the perfusion solution are brought into contact with each other while applying oscillation to the organ.Type: ApplicationFiled: March 21, 2016Publication date: September 29, 2016Applicant: SYSMEX CORPORATIONInventors: Nobuyasu HORI, Kenji AKAMA
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Publication number: 20160116428Abstract: Disclosed is a method of detecting a test substance contained in a sample using a working electrode and a counter electrode. The method comprises (A) forming a complex on the working electrode, the complex comprising the test substance and a metal particle; (B) washing the working electrode; (C) adding a measurement solution to the working electrode and measuring a current, voltage or electric charge from the metal on the working electrode in the measurement solution by electrochemical measurement; and (D) detecting the test substance in the sample based on a measurement result obtained in the step (C). In the method, the step (B) comprises washing the working electrode using a measurement solution having the same composition as the composition of the measurement solution used in the step (C).Type: ApplicationFiled: October 27, 2015Publication date: April 28, 2016Applicant: SYSMEX CORPORATIONInventors: Nobuyasu HORI, Yuichi YASUDA, Hiroya KIRIMURA, Yuzuru TAKAMURA, Miyuki CHIKAE
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Publication number: 20150353892Abstract: Disclosed is a method of collecting cells including the steps of: preparing a processed-bone comprising a bone extracted from a living body, a covering agent and first and second holes, wherein an outer surface of the bone is covered with the covering agent attached to the outer surface of the bone, and the first and second holes penetrate through the covering agent and the outer surface of the bone into the interior of the bone; introducing a liquid into the processed-bone from the first hole; and collecting a cell-containing liquid from the second hole.Type: ApplicationFiled: May 27, 2015Publication date: December 10, 2015Applicant: SYSMEX CORPORATIONInventors: Kenji Akama, Nobuyasu Hori
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Patent number: 9157884Abstract: In order to provide a method of electrochemically detecting a target substance, a method of electrochemically detecting an analyte, and a detection set which have a theoretical advantage in the measurement sensitivity obtained by a conventional electrochemical detection method using a working electrode with a trapping substance immobilized, can reuse the working electrode, and can detect an analyte regardless of the size thereof, there is provided a method including: attracting the target substance containing a labeling substance in a liquid sample to a working electrode in which a trapping substance for trapping the target substance containing a labeling substance is not present; and electrochemically detecting the target substance containing a labeling substance.Type: GrantFiled: August 25, 2011Date of Patent: October 13, 2015Assignee: SYSMEX CORPORATIONInventors: Masayoshi Seike, Nobuyasu Hori, Seigo Suzuki, Shigeki Iwanaga, Hiroya Kirimura
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Publication number: 20150275176Abstract: Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells introduced to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate, thereby obtaining differentiated cells and/or differentiated cell products; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.Type: ApplicationFiled: March 30, 2015Publication date: October 1, 2015Applicant: SYSMEX CORPORATIONInventors: Eiji KOBAYASHI, Toshiyuki SATO, Kenji AKAMA, Nobuyasu HORI, Masaki SHIBAYAMA, Yuki AIHARA, Masakazu KADOWAKI
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Patent number: 9057688Abstract: A detection device for detecting a test substance which is capable of detecting a test substance and a sample substance with high sensitivity, an electrode substrate, a working electrode, an inspection tip, a method of detecting a test substance, and a method of detecting a sample substance are provided in which a reflective part (reflective layer) is disposed on the working electrode so as to reflect excitation light emitted from a light source and passing through the working electrode toward the working electrode.Type: GrantFiled: October 20, 2011Date of Patent: June 16, 2015Assignee: SYSMEX CORPORATIONInventors: Nobuyasu Hori, Hiroya Kirimura
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Patent number: 8920626Abstract: A sample substance S is captured by a capture substance 10 which is immobilized on a working electrode body 161 to provide a method of electrochemically detecting a sample substance capable of detecting the sample substance with high sensitivity. A complex which includes, on a soluble carrier 21, a sample substance S and a labeled binder 20 that has a modified labeled substance 23 containing a labeled substance 20 bound to modified labeled substance 23 containing a labeled substance 24 and a binder 22 that binds to the sample substance S, formed on the working electrode 161. The soluble carrier 21 is dissolved, and the modified labeled substance 23 is attracted to the working electrode 161.Type: GrantFiled: November 29, 2011Date of Patent: December 30, 2014Assignee: Sysmex CorporationInventors: Seigo Suzuki, Masayoshi Seike, Shigeki Iwanaga, Nobuyasu Hori, Hiroya Kirimura
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Publication number: 20140291166Abstract: A method for electrochemically detecting an analyte contained in a sample using a working electrode and a counter electrode, comprising: allowing an electrolyte solution which contains a solution prepared by dissolving an imidazolium iodide compound in a protic solvent to be into contact with the working electrode and the counter electrode; and electrochemically detecting the analyte contained in the sample in the presence of the electrolyte solution is disclosed. A kit to be used for the method for electrochemically detecting an analyte is also disclosed.Type: ApplicationFiled: March 27, 2014Publication date: October 2, 2014Applicant: SYSMEX CORPORATIONInventors: Fumiya FUTAMATSU, Hiroya KIRIMURA, Shigeki IWANAGA, Seigo SUZUKI, Nobuyasu HORI, Yuichi YASUDA