Patents by Inventor Nobuyoshi Chiba

Nobuyoshi Chiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purine derivative
    Patent number: 6028076
    Abstract: This invention relates to novel purine derivatives of formula (I): ##STR1## where R.sup.2 and R.sup.9 are hydrocarbon groups, R.sup.6 is an amino group and R.sup.8 is a hydroxyl, or acyloxy group. These purine derivatives are effective at promoting secretion of interferon in patients, and can be used to treat diseases against which interferon is effective.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: February 22, 2000
    Assignee: Japan Energy Corporation
    Inventors: Kohsaku Hirota, Yoshiaki Isobe, Nobuyoshi Chiba, Harumi Satoh, Haruo Takaku, Hiroyuki Matsui, Haruhisa Ogita
  • Pyrazole derivatives and their pharmaceutical use
    Patent number: 5849779
    Abstract: The present invention relates to a pyrazole derivative represented by formula (I) or (II) ##STR1## wherein R.sup.1 is hydrogen C2-C6 alkyl benzyl or phenyl; each of R.sup.2 and R.sup.3 is hydrogen, C1-C6 alkyl or benzyl; each of R.sup.4 and R.sup.5 is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl, benzyl or phenyl;X is oxygen or sulfur;R.sup.5 is hydrogen, C2-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl or benzyl when R.sup.1 is benzyl, R.sup.2 is ethyl, R.sup.3 is hydrogen, and R.sup.4 is hydrogen, and its pharmaceutical use.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: December 15, 1998
    Assignee: Japan Energy Corporation
    Inventors: Kohsaku Hirota, Hironao Sajiki, Yoshiaki Isobe, Yoichi Ohba, Hiroyuki Morita, Haruo Takaku, Nobuyoshi Chiba
  • Purine derivatives and suppressants for inflammatory diseases
    Patent number: 5602140
    Abstract: Purine derivatives shown by general formula [I] or pharmacologically acceptable salts thereof. Suppressants for inflammatory diseases containing an effective ingredient of said purine derivative. ##STR1## (wherein, R represents one group selected from the groups composed of H atom, a straight chain alkyl group having 1-10 carbon atoms, a branched chain alkyl group having 3-10 carbon atoms, an alkyl group having 1-10 carbon atoms substituted with one carboxyl group, 4-carboxybenzyl group and phenethyl group).Above mentioned purine derivatives prevent the tissue damages due to mediators such as active oxygen and TXA.sub.2 in the initial stage of inflammation, and prevent the subsequent aggravation of inflammatory responses due to the adhesion of activated leukocytes to the cells in the lesion, and exhibit efficacy as anti-inflammatory drugs in all stages of inflammatory diseases caused by leukocytes.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: February 11, 1997
    Assignee: Japan Energy Corporation
    Inventors: Yoshiaki Isobe, Nobuyoshi Chiba, Yuso Goto, Hideharu Sato