Patents by Inventor Nobuyoshi Shimada
Nobuyoshi Shimada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5283331Abstract: It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1): ##STR1## wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue ##STR2## or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.Type: GrantFiled: December 9, 1991Date of Patent: February 1, 1994Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Akira Masuda, Masayuki Kitagawa, Nobuyoshi Shimada, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama
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Patent number: 5214048Abstract: This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.Type: GrantFiled: November 20, 1989Date of Patent: May 25, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takayuki Tomizawa, Seiichi Saito, Kyoichi Shibuya, Akio Fujii, Hiroo Hoshino, Kenichi Matsubara, Takemitsu Nagahata, Katsutoshi Takahashi, Yukihiro Nishiyama
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Patent number: 5179084Abstract: The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.Type: GrantFiled: April 4, 1990Date of Patent: January 12, 1993Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Katsutoshi Takahashi, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama, Kenichi Matsubara, Takemitsu Nagahata
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Patent number: 5164500Abstract: Oxetanocin G which is expectedly useful as an antiviral agent.Type: GrantFiled: November 28, 1990Date of Patent: November 17, 1992Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada
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Patent number: 5041447Abstract: This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),(b) Y represents ##STR2## provided that R.sub.2 is --H, --OH or --CH.sub.2 OH and R.sub.3 is --H, --OH, halogen atom, --CH.sub.2 OH, lower alkyl group, --CH.sub.2 -N.sub.3, --CH.sub.2 -F, --N.sub.3, --COOH, --NH.sub.2, --CH.sub.2 OSO.sub.3 H or --CH.sub.2 OCO-(lower alkyl), and(c) B represents a residue of purine base,(d) provided that R.sub.1 and R.sub.3 cannot simultaneously represents --CH.sub.2 OH]and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.Type: GrantFiled: March 17, 1989Date of Patent: August 20, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Katsutoshi Takahashi, Nobuyoshi Shimada, Jun-ichi Seki, Hiroo Hoshino, Yukihiro Nishiyama, Kenichi Matsubara, Takemitsu Nagahata
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Patent number: 5003056Abstract: This invention relates to an antibiotic NK86-0279 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.Type: GrantFiled: December 22, 1988Date of Patent: March 26, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Takaaki Nishikiori, Masanori Yamazaki, Seiichi Saito, Nobuyoshi Shimada, Takashi Kurokawa, Kiyonobu Hirose, Takumi Yamshita, Takako Tsuchiya, Takashi Harada
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Patent number: 4994582Abstract: This invention relates to an antibiotic NK130119 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.Type: GrantFiled: January 17, 1990Date of Patent: February 19, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Takaaki Nishikiori, Masanori Yamazaki, Seiichi Saito, Nobuyoshi Shimada, Takashi Kurokawa, Kiyonobu Hirose, Takumi Yamashita, Takashi Harada
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Patent number: 4992368Abstract: The present invention provides a novel process for producing oxetanocin G by hydrolysis of alkoxylated 2-amino-oxetanocin A thereby to convert ##STR1## at the 6-position thereof into >C.dbd.O. Oxetanocin G is expectedly useful as an antiviral agent.Type: GrantFiled: April 12, 1990Date of Patent: February 12, 1991Assignee: Nippon Kayaku Kabushiki KaishaInventors: Seiichi Saito, Shigeru Hasegawa, Masayuki Kitagawa, Nobuyoshi Shimada, Noriyuki Yamashita
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Patent number: 4904585Abstract: This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineo-plastic activities and is expected as a pharmaceutical as well as a process for the production of the same.Type: GrantFiled: November 2, 1987Date of Patent: February 27, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takashi Harada, Takayuki Tomizawa, Akio Fujii
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Patent number: 4892876Abstract: A pharmaceutical composition for inhibiting Human Immunodeficiency Virus (HIV), which is characterized by comprising a compound represented by the formula (1) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: March 24, 1988Date of Patent: January 9, 1990Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hiroo Hoshino, Nobuyoshi Shimada
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Patent number: 4845215Abstract: The present invention relates to a novel compound having hypoxanthine base represented by the following formula: ##STR1## as well as to use of said compound and process for producing said compound.The novel compound of the present invention has an immunosuppressive and antiviral actions and is expected to be useful as a medical drug.Type: GrantFiled: May 26, 1987Date of Patent: July 4, 1989Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Takayuki Tomizawa, Shigeru Hasegawa, Kaoru Matsuo, Akio Fujii, Hiroo Hoshino
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Patent number: 4743689Abstract: This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineoplastic activities and is expected as a pharmaceutical as well as a process for the production of the same.Type: GrantFiled: November 8, 1985Date of Patent: May 10, 1988Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nobuyoshi Shimada, Shigeru Hasegawa, Takashi Harada, Takayuki Tomizawa, Akio Fujii
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Patent number: 4721005Abstract: A robot apparatus is operable in a Cartesian coordinate system for moving a workpiece gripped by a hand thereof. The robot apparatus includes a self-propelled X-axis slide unit movably mounted on an X-axis rail unit extending in the direction of the X-axis of the Cartesian coordinate system. A Y-axis slide unit extending in the Y-axis direction normal to the X-axis direction has one end fixed to the X-axis slide unit. A self-propelled Z-axis slide unit is movably mounted on the Y-axis slide unit, and a slide base to which the robot hand is attached is mounted on the Z-axis slide unit. Lead wires connected to drive mechanisms for driving the X-axis slide unit, the Y-axis slide unit, and the Z-axis slide unit pass through case members, and are housed in the X-axis rail unit and connected to a terminal box secured to an end of the X-axis rail unit.Type: GrantFiled: June 5, 1986Date of Patent: January 26, 1988Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Takeo Yoshiji, Kimitake Uzuyama, Nobuyoshi Shimada, Takayuki Hoshino
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Patent number: 4530998Abstract: This invention relates to 2'-deoxy-oxanosine represented by the following formula: ##STR1## and process for the preparation thereof. This new compound exhibits a growth inhibiting action to gram-negative bacteria and has a carcinostatic action.Type: GrantFiled: March 5, 1984Date of Patent: July 23, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku KenkyuKaiInventors: Hamao Umezawa, Tomio Takeuchi, Masaaki Ishizuka, Tomohisa Takita, Nobuyoshi Shimada, Kuniki Kato
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Patent number: 4495347Abstract: The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.Type: GrantFiled: November 5, 1982Date of Patent: January 22, 1985Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi
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Patent number: 4394446Abstract: The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.Type: GrantFiled: November 20, 1981Date of Patent: July 19, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi
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Patent number: 3984390Abstract: By adding a specific amine in culturing under aerobic conditions actinomycetales capable of producing phleomycin group antibiotics, which have been inoculated into a nutrient medium to produce antitumor phleomycin group antibiotics, it is possible to obtain specific phleomycin group antibiotics having a side chain structure corresponding to said amine. The phleomycin group antibiotics thus produced are collected from the culture medium in a conventional way.Type: GrantFiled: March 2, 1973Date of Patent: October 5, 1976Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Akio Fujii, Tomohisa Takita, Nobuyoshi Shimada
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Patent number: RE30451Abstract: A novel process for producing antibiotics bleomycins by innoculating and aerobically culturing in a nutrient source-containing medium a bleomycin-producing strain belonging to the actinomyces, wherein the culture is effected in the presence of an amino compound having at least one ##STR1## group and at least one basic group selected from amino, imino, guanidino, amidino and sulfonium groups and nitrogen-containing cyclic compounds, or in the presence of a compound convertible in the culture liquor to such amino compound as mentioned above, thereby selectively producing a known or novel bleomycin component corresponding to the said amino compound or to an amino compound derived from the above-mentioned compound, and then the known or novel bleomycin is recovered by known means from the culture medium.Type: GrantFiled: May 24, 1979Date of Patent: December 16, 1980Assignee: Zaidan Jojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Kenji Maeda, Tomohisa Takita, Yuya Nakayama, Akio Fujii, Nobuyoshi Shimada, Hideo Chimura