Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 µm or smaller, and 0 < B/A ? 0.

Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.

Abstract: Spectral data indicating an intensity of electromagnetic waves, which have been emitted to a cell suspension including a cell and a culture solution and have been subjected to an action of the cell suspension, for each wave number or wavelength is acquired. Preprocessing is performed on the spectral data. A soft sensor, which receives processed data obtained by the preprocessing as an input and outputs state data indicating a state of the cell or the culture solution, is constructed by machine learning using a plurality of combinations of the processed data and the state data as training data. The processed data for the spectral data acquired for a cell suspension including a cell which is being cultured is input to the soft sensor, and the state data output from the soft sensor is acquired.

Abstract: A cell culture device (1) includes: a culture vessel (10 ) that accommodates a cell suspension containing cells and a culture medium; and a stirring device (30) that is provided at a bottom part of the culture vessel (10) to stir the cell suspension accommodated in the culture vessel (10). The stirring device (30) has a shaft part (32), and a rotating part (33) rotatable with the shaft part (32) as a rotation axis. The rotating part (33) has a hole part (36) into which the shaft part (32) is inserted, and a gap (37) of 100 ?m or more is secured between an interior wall demarcating the hole part (36) and the shaft part (32). A closing part (38) that closes an end part of the gap (37) in an axial direction of the rotation axis is provided.

Abstract: An information processing apparatus acquires input information including at least one of a process condition, a culture medium component, or the number and diameters of cells in cell culture, and estimates a quality of an antibody produced from the cells and a quality of the cells after elapse of a predetermined period from a time point at which the input information is acquired, on the basis of the input information and a trained model which is trained in advance using the input information, the quality of the antibody, and the quality of the cells.

Abstract: An information processing apparatus estimates a quality of an antibody produced from cells and a quality of the cells on the basis of a culture state of the cells, searches for the culture state of the cells that improves the estimated quality of the antibody and the estimated quality of the cells, and derives process conditions for cell culture in which a culture state of the cells is the searched culture state.

Abstract: Provide are a cell culture method which includes using a culture vessel which contains a cell suspension containing cells and discharging a gas including 30% by volume or more of oxygen into the cell suspension from a sparger disposed in the culture vessel to culture the cells, in which an average hole diameter in a gas discharge portion in the sparger is 1 ?m or more and 300 ?m or less, and a surface area A (m2) in the gas discharge portion in the sparger, a volume X (m3) of the cell suspension in the culture vessel, and a flow rate Q (m3/min) of the gas that is discharged from the sparger satisfy a specific relationship, a product producing method including the cell culture method, and a cell culture device that enables the cell culture method.

Abstract: Provided is a cell culture apparatus including a culture vessel that stores a cell suspension containing cells; a first filter part that has a first filter membrane that performs membrane separation treatment on the cell suspension extracted from the culture vessel; a first circulation flow path that allows components blocked by the first filter membrane to return to the culture vessel; a second filter part that has a second filter membrane that performs membrane separation treatment on components of the cell suspension permeated through the first filter membrane; a second circulation flow path that allows components permeated through the second filter membrane to return to the culture vessel; and a recovery flow path that recovers components blocked by the second filter membrane. In the cell culture apparatus, an average hole diameter of the first filter membrane is 20 ?m or smaller, and 0<B/A?0.

Abstract: The present invention provides: a soft capsule preparation which includes a self-emulsifying composition containing an oily component, an emulsifier, 8% by mass to 20% by mass of a polyhydric alcohol and 2.5% by mass to 5% by mass of water, and a capsule film containing 35% by mass to 50% by mass of a polyhydric alcohol and gelatin, in which capsule film the above-described self-emulsifying composition is encapsulated; a method of producing the soft capsule preparation; a composition for a soft capsule preparation, which is an intermediate product of the soft capsule preparation; and a self-emulsifying composition and a capsule film composition that are used in the composition for a soft capsule preparation.

Abstract: The present invention provides a method of producing a collagen peptide-containing composition, the method including performing a masking treatment including reacting, in a liquid having a pH of from 5 to 12 at a temperature of from 70° C. to 100° C. for 0.01 hour to 2 hours, a collagen peptide having an average molecular weight of 1,200 or less with a saccharide in an amount of from 0.0001 to 0.05 parts by mass of with respect to 1 part by mass of the collagen, the saccharide being capable of undergoing Maillard reaction with an amino group in the collagen peptide.

Abstract: A heat-sensitive transfer image-receiving sheet containing at least one heat insulation layer and at least one receptor layer on a support, wherein said heat insulation layer contains at least one kind of hollow polymer particles and said receptor layer contains at least one latex polymer and at least one water-soluble polymer; wherein said water-soluble polymer is at least one of a gelatin and a polyvinyl alcohol in which the gelatin has an average molecular mass of 20,000 or more and the polyvinyl alcohol has a saponification degree of 95% or more and an average polymerization degree of from 200 to 1600 or has a saponification degree of less than 95% and an average polymerization degree of from 500 to 2000.

Abstract: A heat-sensitive transfer sheet comprising at least three different kinds of heat-sensitive transfer dye layers each comprising at least one yellow, magenta or cyan dye and at least one binder resin, provided on a support, and at least one thermal transferable protective layer capable of peeling, comprising a releasing layer, a peeling layer and an adhesion layer, provided on the support in this order, and wherein a surface of the support to which the releasing layer of said protective layer adheres has been subjected to an atmospheric pressure plasma treatment.

Abstract: A heat-sensitive transfer image-receiving sheet containing at least one heat insulation layer and at least one receptor layer on a support, wherein said heat insulation layer contains at least one kind of hollow polymer particles and said receptor layer contains at least one latex polymer and at least one water-soluble polymer; wherein said water-soluble polymer is at least one of a gelatin and a polyvinyl alcohol in which the gelatin has an average molecular mass of 20,000 or more and the polyvinyl alcohol has a saponification degree of 95% or more and an average polymerization degree of from 200 to 1600 or has a saponification degree of less than 95% and an average polymerization degree of from 500 to 2000.

Abstract: An image-forming method comprising employing (1) a heat-sensitive transfer image-receiving sheet having a support, at least one dye receptor layer on the support, and at least one heat insulation layer containing both hollow polymer particles and a hydrophilic polymer, the heat insulation layer being disposed between the receptor layer and the support, and (2) a heat-sensitive transfer sheet having at least one yellow heat transfer layer, at least one magenta heat transfer layer, and/or at least one cyan heat transfer layer on a support, wherein at least two of a yellow dye, a magenta dye, and a cyan dye, each incorporated in the corresponding heat transfer layer, are specific compounds.

Abstract: The present invention provides a silver halide color photographic photosensitive material that includes coupler-containing sensitive emulsion layer units on a support. Each of the photosensitive emulsion layer units are constituted of at least two photosensitive emulsion layers having sensitivities which are different from each other. An emulsion layer of the highest sensitivity among the at least two photosensitive emulsion layers contains at least one silver halide emulsion in which tabular silver halide grains with an average aspect ratio of 3 or more substantially including dislocation lines account for 50% or more of the total projected areas. Photosensitive emulsion layers other than the emulsion layer of the highest sensitivity consist of a silver halide emulsion containing silver halide grains that account for 70% or more of the total projected areas and include host grains that satisfy a specific aspect ratio condition and epitaxially joined protrusions.

Abstract: A silver halide color reversal photosensitive material comprising a blue-sensitive emulsion layer unit containing a yellow color-forming coupler, a green-sensitive emulsion layer unit containing a magenta color-forming coupler and a red-sensitive emulsion layer unit containing a cyan color-forming coupler, on a transparent support, wherein the material includes at least one interimage effect-donating layer substantially forms no image; the wavelength, ?rmax, at which the maximum sensitivity of the spectral sensitivity distribution of the red-sensitive layer unit is given, satisfies the relation: 620 nm??rmax?680 nm; and the sensitivities of the red-sensitive layer unit satisfy the following relationships: Sr(610) is ? of Sr(?rmax) or more; Sr(680) is 1/10 of Sr(?rmax) or more; and/or Sr(690) is 1/50 of Sr(?rmax) or more wherein Sr(610), Sr(680) and Sr(690) are the sensitivities of the red-sensitive unit at 610 nm, 680 nm and 690 nm, respectively, and Sr(?rmax) is the maximum sensitivity at ?rmax.

Abstract: The present invention provides a silver halide color photographic photosensitive material that includes coupler-containing sensitive emulsion layer units on a support. Each of the photosensitive emulsion layer units are constituted of at least two photosensitive emulsion layers having sensitivities which are different from each other. An emulsion layer of the highest sensitivity among the at least two photosensitive emulsion layers contains at least one silver halide emulsion in which tabular silver halide grains with an average aspect ratio of 3 or more substantially including dislocation lines account for 50% or more of the total projected areas. Photosensitive emulsion layers other than the emulsion layer of the highest sensitivity consist of a silver halide emulsion containing silver halide grains that account for 70% or more of the total projected areas and include host grains that satisfy a specific aspect ratio condition and epitaxially joined protrusions.

Abstract: A silver halide color reversal photosensitive material comprising a blue-sensitive emulsion layer unit containing a yellow color-forming coupler, a green-sensitive emulsion layer unit containing a magenta color-forming coupler and a red-sensitive emulsion layer unit containing a cyan color-forming coupler, on a transparent support, wherein the material includes at least one interimage effect-donating layer substantially forms no image; the wavelength, &lgr;rmax, at which the maximum sensitivity of the spectral sensitivity distribution of the red-sensitive layer unit is given, satisfies the relation: 620 nm≦&lgr;rmax≦680 nm; and the sensitivities of the red-sensitive layer unit satisfy the following relationships: Sr(610) is ⅕ of Sr(&lgr;rmax) or more; Sr(680) is {fraction (1/10)} of Sr(&lgr;rmax) or more; and/or Sr(690) is {fraction (1/50)} of Sr(&lgr;rmax) or more wherein Sr(610), Sr(680) and Sr(690) are the sensitivities of the red-sensitive unit at 610 nm, 680 nm and 690 nm, respectively, and

Abstract: A silver halide photographic emulsion comprising grains, wherein 70% or more of the total projected area of the grains is occupied by silver halide grains each meeting requirements (a) to (d) below (a) the grain is composed of a tabular silver halide host grain having two mutually parallel main planes and aspect ratio of 2 or more, and a silver halide protrusion portion epitaxially junctioned on the surface of the host grain; (b) the silver bromide contents of both the host grain and the protrusion portion are 70 mol % or more; (c) the percentage of the silver amount in the protrusion is 12% or less of the silver amount in the host grain; and (d) the grain has a shallow electron-trapping zone.

Abstract: A silver halide photographic emulsion comprising grains, wherein 70% or more of the total projected area of the grains is occupied by silver halide grains each meeting requirements (a) to (d) below