Abstract: Described herein are mRNA-based and peptide-based therapeutic vaccines comprising modified TNFR2 sequences complementary to variants of Homo sapiens TNFR2 genes and methods for treating subjects having atherosclerosis.

Abstract: Described herein are antisense inhibitor adjuvant compositions comprising modified nucleotide sequences complementary to a Homo sapiens interleukin 10 (IL-10) or interleukin 10 receptor alpha (IL-10RA) genes and methods for use thereof.

Abstract: Described herein is a method for cancer immunotherapy by administering to a subject an mRNA vaccine designed to express the carbonyl terminal segment of human chorionic gonadotropin (hCG). Also described an improved adjuvant by co-administration of an antisense IL-10 molecule to shift the vaccine immune response to enhanced T-cell responses to hCG. Other embodiments relate to devices and methods for improved delivery of the mRNA vaccine and adjuvant. The intended use involves repeated administration of the vaccine components to subjects over an interval of several months in a repeated boosting strategy.