Abstract: Rapid reconstitution package. The package includes a substantially cylindrical structure including a diluent chamber and a drug chamber communicating through a valve. The cylindrical structure is configured to retract under an axial force causing the valve to open to allow the diluent to flow through the valve into the drug chamber for mixing and reconstitution of the drug. The drug chamber shape is tuned to enhance mixing. In another aspect, the invention is a method for designing a rapid reconstitution package using computational fluid dynamics techniques.

Abstract: Exemplary embodiments provide dispensers and delivery devices that release their contents at sustained rates. An exemplary device may include one or more reservoirs for holding a solid, semisolid, liquid or gaseous substance that may be released outside the device. Exemplary devices enable sustained release of their contents over a predetermined period of time, for example, up to a month or more. Exemplary devices also enable release of the contents according to, for example, predetermined release rates and profiles customized for the use of the device. Each reservoir of the device may include one or more apertures through which the contents may be released outside the reservoir. Each aperture may be covered by one or more porous membranes to allow sustained release of the contents of the reservoir.

Abstract: Stent devices comprising an inflatable inner balloon defined by an envelope and an outer balloon surrounding the inner balloon concentrically, the outer balloon serving as a therapeutic agent reservoir used for controlled therapeutic agent delivery. In some embodiments, the outer balloon has two separate walls which define its volume and is independently inflatable. In some embodiments, the two concentric balloons form a substantially cylindrical structure which has a proximal end and a distal end. A catheter carrying inflation and drainage lumens extends outward from the proximal end. In some embodiments, the distal end includes an embedded cervix accommodating tip or has a non-embedded cervix accommodating tip attached thereto. The stent devices can be used to maintain the integrity and placement of vaginally placed mesh or graft after reconstructive procedures, prevent vaginal hematoma formation and bleeding, provide pain control after surgery and deliver antibiotics or hormones to the vaginal epithelium.